The invention discloses an imidazole aldehyde waste water treatment process and an operating method thereof, and belongs to the technical field of waste water treatment. The treatment process provided by the invention comprises primary wet oxidation, primary nanofiltration, primary freezing, secondary wet oxidation, secondary nanofiltration, secondary freezing and evaporative crystallization, wherein a biochemical area comprises a pH neutralizing pool, a biochemical adjusting pool, a UASB reactor, an A/O pool, a secondary sedimentation pool and a mixed sedimentation pool. Through physical and chemical pretreatment of midazole aldehyde waste water, the COD concentration can be greatly reduced to 3000 mg/L, pure organic P can be recycled, and the residual organic P is transformed into inorganic P, so that removal of P from the midazole aldehyde waste water by the biochemical area is enhanced. After waste water subjected to physical and chemical pretreatment and domestic waste water are mixed, the COD and the P are removed from the waste water through biochemical treatment; and PAC and PAM are emergently added in the mixed sedimentation pool to enhance removal of COD and P precipitate, so that reduction of the biochemical action of the active sludge in the biochemical area in winter is avoided, and the midazole aldehyde waste water is efficiently removed.