The invention discloses a sesame no-tillage sowing method in a wheat and ganoderma lucidum rotation mode, which comprises the following steps: 1, normally planting wheat from the middle ten days of October to the middle ten days of May in the next year; 2, in the middle of May, 1-3 days before wheat harvesting, sesame seeds are sprayed with an airplane; thirdly, a harvester is normally used for harvesting wheat, and wheat straw is normally smashed through the harvester; 4, after sesame seedlings emerge, topdressing is carried out after raining, and other management is the same as conventional field planting management; the wheat and ganoderma lucidum rotation field adopts a no-tillage aerial seeding technology, so that the mechanical rotary tillage cost can be saved; (2) the sowing time of the sesame is advanced by about 5 days, and the sesame yield increase is promoted; (3) compacting by a crawler belt of the harvester and covering by the crushed wheat straws to form a good sesame seedling emergence environment, so that the sesame seedlings are orderly, neat and strong; (4) fine topdressing can be carried out according to the growth vigor of the sesame in the later period, and fertilizer and cost are saved.