The invention discloses oversized ferrite for a particle acceleration device and a preparation method of the oversized ferrite, aiming at solving the problems that the conventional oversized ferrite has the requirements on oversize and high performance indexes, only can be produced through an adhesive mode and is limited in performance, phenomena such as breakage, layering, deformation, instable indexes caused by the high-temperature action are caused and the production cost is very high. The oversized ferrite is prepared by taking Fe2O3, NiO, ZnO, CuO, Co2O3, MnCO3, V2O5 and MgCl2.6H2O as raw materials. The ratio of the raw materials is adjusted, a sintering process is improved, the problems that the oversized ferrite is broken, layered and deformed in the sintering process and the like are effectively solved, and the prepared oversized ferrite has the advantages of large size and excellent performance. Meanwhile, the oversized ferrite is subjected to one-step integral molding by adopting a sintering mode and is not needed to be adhered through small blocks, the product performance is greatly improved, and the production cost of the product is further reduced.