A fluidic
microsystem 100 for manipulating particles 1, 2, 3, for example biological cells, comprises a
fluidic channel arrangement 10 configured to receive a flow of a fluid 4 with a flow direction S in which the particles 1, 2, 3 are arranged, and which successively includes in the flow direction S a first analysis section 11A, a first
actuator section 12A and a second analysis section 11B, a
detector device 20 with a
field of view 21 covering the first analysis section 11A and the second analysis section 11B, wherein the
detector device 20 is configured for
radiation-based detection of at least one particle property of each of the particles 1, 2, 3 in the first analysis section 11A and in the second analysis section 11B, and an
actuator device 30 configured to subject each of the particles 1, 2, 3 in the first
actuator section 12A to a first actuator step.in particular, comprising at least one of the following: the application of a trigger action, the performance of a measurement, and the application of an actuating force. The
fluidic channel arrangement 10 has a reversing section 13 with a first leg 13A, a reversing curve, and a second leg 13B, wherein the first analysis section 11A is arranged in the first leg 13A and the second analysis section 11B is arranged in the second leg 13B adjacent to the first analysis section 11A with respect to a direction transverse to the flow direction S. A particle manipulation method for manipulating particles 1, 2, 3 in a fluidic
microsystem is also described.