The invention discloses a river regulation system, which comprises a filter tank, a mixed reaction tank, a biological cleaning tank, a first vegetation purification wetland, a second vegetation purification wetland, a sedimentation tank and a reservoir, wherein the filter tank, the mixed reaction tank, the biological cleaning tank, the first vegetation purification wetland, the second vegetation purification wetland, the sedimentation tank and the reservoir are arranged according to a river sewage treatment process, wherein filtering baskets are arranged in the filter tank and are respectivelya first-level filtering basket and a second-level filtering basket; a flocculant adding device is arranged out of the mixed reaction tank and is communicated with the mixed reaction tank; a slag discharging groove and a mixer area arranged in the mixed reaction tank; the biological cleaning tank comprises a composite microorganism aeration oxygenation device; the first vegetation purification wetland and the second vegetation purification wetland are both constructed wetlands and respectively comprises a border, a gravel layer, a medium sand layer and a fine sand layer, wherein the gravel layer, the medium sand layer and the fine sand layer are arranged in sequence from top to bottom. According to the river regulation system disclosed by the invention, the problems of low processing efficiency and large vegetation wetland land occupation of a traditional river regulation system can be solved; in addition, mixed reaction, biological cleaning and vegetation wetland purification are combined to form one set of river regulation system with low cost, high processing efficiency and stability in system operation.