Traditional Chinese medicine for treating and/or preventing gastrointestinal dysfunction caused by critical diseases

A technology for gastrointestinal dysfunction and critical illness, applied in the field of medicine, can solve problems such as increased fatality rate, inability to effectively prevent gastrointestinal failure, etc., and achieve the effect of reducing the incidence rate, preventing gastrointestinal dysfunction, and no toxic and side effects.

Inactive Publication Date: 2014-03-26
LIUZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gastrointestinal failure is quite common in critically ill patients. In clinical work, although comprehensive treatment measures such as active treatment of the primary disease and removal of the cause, the occurrence of gastrointestinal failure cannot be effectively prevented. The gastrointestinal mucosal barrier is damaged, Intestinal paralysis, large amounts of bacteria and toxins deposited in the intestinal lumen, promote the occurrence and development of systemic inflammatory response syndrome and MODS, resulting in increased mortality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Codonopsis 50g Stir-fried Atractylodes macrocephala 40g Poria cocos 50g Roasted licorice 20g

[0050] Yam 50g White lentils 40g Coix seed 20g Amomum 20g

[0051] Bellflower 20g, pomegranate peel 40g, myrobalan 40g, red stone fat 20g

[0052] Take all 12 medicinal materials, add water to extract twice, each time add water equivalent to 10 times and 8 times the total weight of the medicinal materials, and the extraction time is 3 hours and 2 hours respectively; the combined extracts are concentrated to 80 ° C. For the extract with a density of 1.10, add ethanol until the volume percentage concentration of the alcohol content is 50%, stir evenly, let it stand for 12 hours, filter, and when the filtrate is concentrated to 80°C, the extract with a relative density of 1.10 is obtained. active ingredients.

Embodiment 2

[0054] Codonopsis 300g Stir-fried Atractylodes 280g Poria cocos 300g Roasted licorice 250g

[0055] Yam 300g White lentils 280g Coix seed 250g Amomum 250g

[0056] Bellflower 250g Pomegranate peel 280g Myrobalan 280g Red stone fat 250g

[0057] Take all 12 medicinal materials, add water to extract three times, each time add water equivalent to 10 times, 8 times, and 6 times the total weight of the medicinal materials, and the extraction time is 3 hours, 2 hours, and 1 hour respectively; combine the extracts and concentrate For the extract with a relative density of 1.10 at 80°C, add ethanol until the volume percentage concentration of the alcohol content is 60%, stir evenly, let stand for 24 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.10 at 80°C , to obtain the active ingredient, add water to 5000g, to obtain the perfusion solution of the present invention.

Embodiment 3

[0059] Codonopsis 150g Stir-fried Atractylodes macrocephala 120g Poria cocos 150g Roasted licorice 100g

[0060] Yam 150g White lentils 120g Coix seed 100g Amomum 100g

[0061] Bellflower 100g, pomegranate peel 120g, myrobalan 120g, red stone fat 100g

[0062] Take all 12 medicinal materials, add water to extract three times, each time add water equivalent to 10 times, 8 times, and 8 times the total weight of the medicinal materials, and the extraction time is 3 hours, 2 hours, and 2 hours respectively; combine the extracts and concentrate To the extract with a relative density of 1.20 at 60°C, add ethanol until the volume percentage concentration of the alcohol content is 50%, stir evenly, let stand for 12 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.20 at 60°C , to obtain the active ingredient.

[0063] The above-mentioned active ingredient is mixed with appropriate amount of starch and dextrin, and granulated to obtain the granule...

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PUM

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Abstract

The invention aims to provide a traditional Chinese medicine for treating and / or preventing gastrointestinal dysfunction caused by critical diseases. The traditional Chinese medicine is prepared from the following raw materials: radix codonopsis, fried largehead atractylodes rhizome, poria cocos, honey-fried licorice root, Chinese yam, white hyacinth bean, coix seed, villous amomum fruit, balloonflower root, pomegranate rind, myrobalan, and red halloysite. The traditional Chinese medicine is prepared according to the theories of tonifying qi, invigorating the spleen, upbearing the clear, and downbearing the turbid, has an integral conditioning effect by simultaneously eliminating and supplementing; can promote the peristalsis and propulsion of gastrointestinal smooth muscle, improves the blood circulation of the intestinal walls, reduces the capillary permeability of the gastrointestinal tracts, relieves the tissue edema, promotes the discharge of dead tissues, inhibits the intestinal bacterium translocation and toxin absorption in the intestines, eliminates the free radicals, and antagonizes the system inflammation reaction. The traditional Chinese medicine for treating gastrointestinal dysfunction caused by critical diseases has a good effect, can control the incidence rate of gastrointestinal dysfunction below 19.05%, does not have any side or toxic effect during the clinical process, and is reliable and safe.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine for treating and / or preventing critical illness complicated with gastrointestinal dysfunction and a preparation method thereof. Background technique [0002] Modern research shows that the gastrointestinal tract undertakes two important functions in the body. Especially when the body is in a state of injury and stress, the gastrointestinal tract not only undertakes the important functions of digesting and absorbing nutrients, but also provides and regulates important immune functions of the whole body. The so-called barrier function of the gastrointestinal tract plays an important role in resisting external bacteria and toxins from entering the body. The quality of gastrointestinal function can sometimes determine the improvement or deterioration of the disease process. The development of clinical nutrition and antibiotics, the advancement of anesthesiolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P1/00A61K33/26
Inventor 郭淋
Owner LIUZHOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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