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Pharmaceutical composition for treating burn and scald as well as preparation method thereof

A composition and technology for burns and scalds, applied in drug combination, drug formula, drug delivery, etc., can solve problems such as aggravation of empyema infection under the scab, accelerated necrotic tissue dissolution, and great influence on liver and kidney functions, so as to reduce tissue edema, Control local infection, anti-inflammatory effect

Inactive Publication Date: 2018-07-17
张爱丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, the problem that tincture exists is: wound surface is stimulated greatly, and early stage pain is obvious, and convergence transition is easy, scab is too thick, empyema infection increases the weight of under scab, has great influence on liver and kidney function, is unfavorable for the defects such as observation
Although traditional Chinese medicine has achieved certain curative effects in the treatment of burn wounds, there are many types of traditional Chinese medicine, the effects are not the same, the treatment time is long, and the old problem of slow curative effect still exists. Anti-inflammatory and analgesic, reduce tissue edema, promote wound blood circulation, protect interstitial ecological tissue to a better outcome, reduce exudation, accelerate necrotic tissue dissolution, meet the supply of oxygen and nutrients to the wound, promote wound healing, and reduce scar formation Drugs with better efficacy

Method used

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  • Pharmaceutical composition for treating burn and scald as well as preparation method thereof
  • Pharmaceutical composition for treating burn and scald as well as preparation method thereof
  • Pharmaceutical composition for treating burn and scald as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A pharmaceutical composition for treating burns and scalds, characterized in that the parts by weight of its constituent raw materials are:

[0025] 60 parts of barley worm essential oil; 10 parts of coptis; 10 parts of cortex; 8 parts of knotweed; 5 parts of raw Burnet; 6 parts of comfrey;

[0026] A preparation method of the pharmaceutical composition for the treatment of burns and scalds:

[0027] (1) First, mix and pulverize 10 parts of Coptis Rhizoma, 10 parts of Phellodendron Phellodendri, 8 parts of Polygonum cuspidatum, 5 parts of Burnet burnet, and 6 parts of Comfrey, then add medicinal ethanol liquid of 3 times the volume of the total of the above components, and the ethanol The concentration is 85%. After reflux extraction for 60 minutes, filter it, and keep the filtrate, and add 1.5 times the same concentration of ethanol to the dregs, and extract twice with the above reflux, each time for 60 minutes, filter it, and keep Filtrate, and 3 filtrates were combi...

Embodiment 2

[0034] A pharmaceutical composition for treating burns and scalds, characterized in that the parts by weight of its constituent raw materials are:

[0035] 75 parts of barley worm essential oil; 5 parts of Coptis chinensis; 5 parts of Cortex Phellodendri; 5 parts of Polygonum cuspidatum; 2 parts of raw Burnet;

[0036] A preparation method of the pharmaceutical composition for the treatment of burns and scalds:

[0037] (1) First, 5 parts of Coptis Rhizoma, 5 parts of Cortex Phellodendri, 5 parts of Polygonum cuspidatum, 2 parts of Burnet burnet, and 6 parts of Comfrey are mixed and pulverized, then add medicinal ethanol liquid of 3 times the volume of the sum of the above components, and the ethanol The concentration is 70%. After reflux extraction for 80 minutes, filter it, and keep the filtrate, and add 1.5 times the same concentration of ethanol to the dregs, and extract once with the above-mentioned reflux for 90 minutes, filter it, and keep filtrate, and the two filtrat...

Embodiment 3

[0044] Treat 127 cases of I, II, and III degree burns with a kind of medicinal composition for treating burns and scalds with barley worm oil prepared in Examples 1, 2, and 3 of the present invention.

[0045] Diagnostic criteria for burns and scalds: I degree (red sore): mild redness, swelling, heat, hyperesthesia, no blisters, obvious edema; II degree is divided into shallow II degree and deep II degree, shallow II degree symptoms are: acute Pain, hyperesthesia, increased temperature, blisters, moist base, uniform red, and obvious edema. The symptoms of deep II degree are: dull pain, with or without blisters, the epidermis is torn off, the base is moist and pale, there are small bleeding spots, and obvious edema. Grade III (eschar): Painless, inelastic, hard like leather, waxy white, browned or charred, subcutaneous venous blockage and dendrites can be seen after drying.

[0046] All 127 cases were outpatients, and the clinical diagnosis was actually burns or scalds. The o...

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Abstract

The invention discloses a pharmaceutical composition for treating burn and scald as well as a preparation method thereof. The pharmaceutical composition comprises the following raw materials in partsby weight: 60 parts of barley pest essential oil, 10 parts of coptis, 10 parts of phellodendron, 6 parts of gentrin knotweed, 5 parts of raw garden burnet, 3 parts of red flower, 5 parts of lithospermum, and 1 part of borneol. Through clinical observation, a dressing formula of the pharmaceutical composition has functions for resisting inflammation and relieving pain, mitigating tissue edema, promoting wound blood circulation, protecting mesenchymal ecological tissue to outcome to a good condition, reducing bleedout, accelerating dissolving of necrotic tissue, satisfying the oxygen and nutrients supply for wound, promoting wound healing, and reducing the scar formation.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating burns and a preparation method thereof, in particular to a pharmaceutical composition for treating burns and scalds, and belongs to the technical field of medicines. Background technique [0002] Burns are tissue damages caused by factors such as heat, light, electricity, chemical substances, and radiation. The damaged parts are mainly in the skin and mucous membranes. In severe cases, they can damage subcutaneous tissues, such as muscles, bones, joints, and even internal organs. It is a complex surgical disease. There are four major problems in the treatment of burns and scalds, namely, wound pain, progressive necrosis, susceptibility to infection, and scar healing. As early as the third century A.D., in Ge Hong's "Behind the Elbow" and "Liu Juanzi Gui Yi Fang" in the Jin Dynasty, there were records of the treatment of water and fire burns, and the treatment concept of both internal a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P17/02A61K35/64A61K31/045
CPCA61K9/0014A61K31/045A61K35/63A61K36/30A61K36/704A61K36/718A61K36/739A61K36/756A61K2236/51A61K2236/39A61K2236/333A61K2300/00
Inventor 张爱丽
Owner 张爱丽
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