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Method for establishing acute lung injury animal model

An acute lung injury, animal model technology, applied in the field of bioengineering, can solve problems such as incompatibility with critically ill patients, gastric acid reflux, etc.

Inactive Publication Date: 2020-10-27
张志辉
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  • Claims
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Problems solved by technology

In order to further study the pathogenic mechanism of acute lung injury, animal models of acute lung injury such as bleomycin, oleic acid and smoke fumigation have been developed and constructed at home and abroad. However, such animal models do not conform to the characteristics of severe patients in clinical practice. That is, critically ill patients often require mechanical ventilation and acid reflux
At the same time, there is no animal model of acute lung injury induced by hydrochloric acid combined with mechanical ventilation at home and abroad.

Method used

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  • Method for establishing acute lung injury animal model
  • Method for establishing acute lung injury animal model
  • Method for establishing acute lung injury animal model

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Embodiment Construction

[0032] In the following description, numerous specific details are given in order to provide a more thorough understanding of the present invention. It will be apparent, however, to one skilled in the art that the present invention may be practiced without one or more of these details. In other examples, some technical features known in the art are not described in order to avoid confusion with the present invention.

[0033] In order to thoroughly understand the present invention, detailed steps and specific structures will be proposed in the following description, so as to illustrate the technical solution of the present invention. Preferred embodiments of the present invention are described in detail below, however, the present invention may have other embodiments besides these detailed descriptions.

[0034] Such as Figure 1-7 As shown, the establishment method of a kind of acute lung injury animal model provided by the invention comprises the following steps:

[0035]...

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Abstract

The invention discloses a method for establishing an acute lung injury animal model, and relates to the technical field of bioengineering. The method for establishing the acute lung injury animal model comprises the following steps: anesthetizing and fixing an experimental animal; inducing acute lung injury of the experimental animal by combining hydrochloric acid with mechanical ventilation; andevaluating the degree of acute lung injury. According to the method, acute pathological injury of the lung of the experimental animal is induced by combining hydrochloric acid with mechanical ventilation, the animal model of acute lung injury can be constructed, and the animal model shows typical characteristics of acute lung injury, such as dyspnea, lung tissue edema and lung tissue fibrosis. Themodel can be used for basic research in the related field of acute lung injury, and lays an experimental animal foundation for exploring the pathogenesis of acute lung injury.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to a method for establishing an animal model of acute lung injury. Background technique [0002] Acute lung injury is a very common life-threatening disease in intensive care medicine, characterized by alveolar epithelial cell damage and increased vascular permeability. It manifests as acute and progressive respiratory failure caused by various pathogenic factors inside and outside the lungs other than cardiogenic, and can develop into respiratory distress syndrome in severe cases. Currently, low tidal volume mechanical ventilation combined with positive end-expiratory pressure, Muscle relaxants and extracorporeal artificial lungs were used in the early days to support the disease, and there was a lack of specific and effective treatment methods. The fatality rate was still as high as 27%-45% depending on the severity. [0003] Mechanical ventilation is currently one of the ...

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Application Information

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IPC IPC(8): A01K67/027
CPCA01K67/027A01K2207/20A01K2207/30A01K2227/105A01K2267/03
Inventor 张志辉孙艺凝
Owner 张志辉
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