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Pharmaceutical composition and application thereof in preparation of medicine for treating acute lung injury

A technology of acute lung injury and composition, applied in the field of medicine, to achieve the effect of reducing mortality, obvious therapeutic effect, and reducing lung coefficient

Active Publication Date: 2022-03-18
LINK HEALTH GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on the combination of compound LH031 and lidocaine in the treatment of acute lung injury

Method used

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  • Pharmaceutical composition and application thereof in preparation of medicine for treating acute lung injury
  • Pharmaceutical composition and application thereof in preparation of medicine for treating acute lung injury
  • Pharmaceutical composition and application thereof in preparation of medicine for treating acute lung injury

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1. The therapeutic effect of LH031 combined with lidocaine on acute lung injury in rats.

[0029] Modeling: 108 8-week-old SPF male SD rats, 200-220g, after anesthesia, disinfect the rat neck with iodine, and make a longitudinal incision of about 1 cm at the midline position of the middle and lower third of the neck to expose the subthyroid Turn the edge upwards, carefully separate and expose the anterior muscle group of the trachea, and sharply separate the muscle group longitudinally to expose the trachea, place the animal obliquely with the head high and the bottom of the feet, and insert a 1mL syringe (26G) into the trachea at about two tracheal rings under the cricoid cartilage ring , push in 2mg / kg LPS solution, the administration volume is 0.8mL / kg, observe that there are no air bubbles in the nose, and immediately turn the rat upright for 20 seconds after pushing in to ensure that the liquid medicine is evenly distributed in the lung tissue and that the m...

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Abstract

The invention relates to the technical field of medicines, and particularly discloses a pharmaceutical composition and application thereof in preparation of a medicine for treating acute lung injury. A composition for treating acute lung injury includes a compound and lidocaine. The pharmaceutical composition provided by the invention can reduce the death rate of animals with acute lung injury, wherein the compound and lidocaine are combined to play a synergistic role in reducing the lung coefficient, the lung permeability index, the release of inflammatory factors and the pathological score of lungs of the animals with acute lung injury.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition and its application in the preparation of medicines for treating acute lung injury. Background technique [0002] Acute lung injury (ALI) is a clinical syndrome that occurs due to characteristic pathological changes in lung tissue structure caused by various reasons. Its pathological features are alveolar capillary endothelial cells and alveolar epithelial cell damage, manifested as extensive pulmonary edema and tiny atelectasis. The pathophysiological changes are mainly increased intrapulmonary shunt and decreased lung compliance. Clinically, hypoxemia, rapid respiratory rate, and diffuse infiltration of both lungs appeared on chest X-ray. ALI has a continuous process from mild to severe, and there is still a lack of effective drugs and methods for the treatment of acute lung injury. [0003] Chinese patent document CN111514137A discloses a compo...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K31/437A61P11/00
CPCA61K31/167A61K31/437A61P11/00A61K2300/00Y02A50/30
Inventor 张时群卢肖宇卢圆
Owner LINK HEALTH GRP
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