Application of pinus yunnanensis pine cone in preparing medicament for treating acute lung injury

Abstract

The invention discloses an application of a pinus yunnanensis pine cone in preparing a medicament for treating acute lung injury. The invention also provides a preparation method of a pinus yunnanensis pine cone extract with a protection function on acute lung injury. Animal experiments prove that the pinus yunnanensis pine cone extract has the function of protecting acute lung injury, so that thepinus yunnanensis pine cone extract can be applied as health food. The main functional effects of the pinus yunnanensis pine cone extract are as follows: the pinus yunnanensis pine cone extract can lower relative mRNA expression of pro-inflammatory genes tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and interleukin 6 (IL-6) by inhibiting TLR4 / NF-kappa B signal pathway andoxidative stress in an acute lung injury (ALI) model, so that secretion of inflammatory factors is reduced, active oxygen free radicals are inhibited, activity of antioxidant enzymes is enhanced, andthus the pinus yunnanensis pine cone extract has a protective effect on LPS-induced rat ALI.

Description

technical field [0001] The invention discloses the use of Yunnan pine cones in preparing medicines for treating acute lung injury, and also provides a preparation method of Yunnan pine cone extracts which have a protective function on acute lung injury, belonging to the technical field of medicine and pharmacy. Background technique [0002] Acute lung injury (ALI) is a common severe pulmonary complication in critical illness caused by various factors such as pneumonia, sepsis, respiratory tract bacterial or viral infection. It is mainly characterized by neutrophil influx, damage to the alveolar-capillary barrier leading to interstitial edema, and impaired respiratory function. Although great progress has been made so far in the research on the pathophysiology of ALI, there is no effective drug for ALI, and it is still the main cause of morbidity and death in critically ill patients. [0003] Studies have shown that the ethanol extract of Pinus yunnanensis Franch., a plant o...

AI Technical Summary

Problems solved by technology

Although great progress has been made so far in the research on the pathophysiology of ALI, there are no effective drugs for ALI, and it is still the main cause of morbidity and mortality in critically ill patients

[0003] Studies have shown that the ethanol extract of Pinus yunnanensis Franch., a plant of the genus Pinus yunnanensis, has various pharmacological activities such as anti-tumor and anti-oxidation, and can significantly inhibit the inflammatory factor tumor necrosis factor in animal models of pulmonary fibrosis Alpha (tumor necrosis factor alpha, TNF-α), interleukin 1 beta (interleukin1 beta, IL-1β), interleukin 6 (interleukin 6, IL-6) and interferon gamma (interferon gamma, IFN-γ) release, however, No in-depth research on acute lung injury

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