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Pharmaceutical composition as well as preparation method and application thereof

A composition and medicine technology, applied in the field of pharmaceutical compositions and their preparation, can solve the problems of long treatment time, obesity, repeated illness, etc., and achieve the effects of reducing the number of coughs, promoting secretion ability, and inhibiting allergic reactions.

Active Publication Date: 2018-12-07
深圳市新鸿镁医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During its long-term use, it is likely to cause side effects such as obesity, and it is prone to repeated illness and long treatment time

Method used

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  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
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preparation example Construction

[0027] Further, the preparation method of the pharmaceutical composition comprises:

[0028] Mix the mixed medicinal materials formed by fennel and spinach and 70-100% ethanol solution according to the ratio of solid to liquid: 1:15-25, and reflux extraction for 2-4 times, each time for 0.5-1.5h, concentrate the obtained extract, dry Dry.

[0029] Preferably, the temperature of the reflux extraction is 60-80°C, or 65-75°C, or 70°C.

[0030] Preferably, the ratio of solid to liquid is 1:17-24, or 1:19-22, or 1:20.

[0031] Preferably, the concentration of the ethanol solution is 80-100%, or 90-100%, or 95%.

[0032] Preferably, extraction is performed 2 to 3 times, 0.8 to 1.2 hours each time; or 3 times, 1 hour each time.

[0033] This embodiment also provides a liquid preparation for treating asthma and allergic rhinitis, which is prepared by mixing the above pharmaceutical composition with sterile water to form a 5-500 g / L medicinal liquid and filtering it.

[0034] Prefe...

Embodiment 1

[0038] This embodiment provides a pharmaceutical composition, which comprises fennel fennel and Oxytropis falciparum at a mass ratio of 1:1.

[0039] The preparation method of this pharmaceutical composition comprises:

[0040] The fennel and Oxytropis falciparum were mixed according to the mass ratio of 1:1, and mixed with 95% ethanol according to the ratio of solid to liquid of 1:20, and refluxed and extracted at 70°C for 3 times, each time for 1h. The supernatant is recovered, concentrated, dried, and pulverized to obtain the obtained product.

Embodiment 2

[0042] The present embodiment provides a pharmaceutical composition, which comprises fennel and Oxytropis falciparum at a mass ratio of 1:5.

[0043] The preparation method of this pharmaceutical composition comprises:

[0044] Mix fennel and Oxytropis falciparum at a mass ratio of 1:5, and with absolute ethanol at a solid-to-liquid ratio of 1:15, and extract twice at 80°C under reflux, each time for 1.5h. The supernatant is recovered, concentrated, dried, and pulverized to obtain the obtained product.

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Abstract

The invention provides a pharmaceutical composition as well as a preparation method and application thereof and belongs to the field of drugs. The pharmaceutical composition is a mixed extract of hypecoum leptocarpum and oxytropis. The pharmaceutical composition can achieve the effects of inhibiting the allergic reaction of the body and local tissue edema caused by allergic media and enhancing thevascular permeability. Meanwhile, the pharmaceutical composition is capable of obviously prolonging latent time of cough and has an obvious effect of inhibiting the cough. In addition, the pharmaceutical composition is capable of obviously promoting tracheal membrane secretion ability and has an obvious effect of irritating the upper respiratory tract to promote sputum excretion. Therefore, the pharmaceutical composition can be used for preparing medicines with effects of resisting allergy, relieving cough, eliminating phlegm and the like, is particularly applicable to preparation of medicines used for treating asthma and allergic rhinitis and has wide application prospects.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a pharmaceutical composition and its preparation method and application. Background technique [0002] Asthma, also known as bronchial asthma, bronchial asthma is a chronic airway inflammation involving a variety of cells and cell components. This inflammation is often accompanied by increased airway responsiveness, resulting in recurrent wheezing, shortness of breath, chest tightness and / or Symptoms such as coughing mostly occur at night and / or in the early morning. Such symptoms are often accompanied by extensive and variable airflow obstruction, which can be reversed spontaneously or through treatment. [0003] At present, in the process of treating allergic diseases such as asthma, hormonal antiallergic drugs are mostly used. During its long-term use, it is likely to cause side effects such as obesity, and it is prone to repeated illness and long treatment time. In view of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P11/06A61P11/02A61P37/08A61P11/10A61P11/14
CPCA61K36/48A61K36/66A61K2236/33A61K2236/333A61K2236/39A61P11/02A61P11/06A61P11/10A61P11/14A61P37/08A61K2300/00
Inventor 陈行平陶燕铎江磊
Owner 深圳市新鸿镁医疗器械有限公司
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