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Medicament for treating chronic cough as well as pharmaceutical composition, preparation method and application thereof

A chronic cough and composition technology, applied in the field of drug research, can solve the problems that patients with chronic cough cannot obtain effective relief, and achieve the effects of prolonging the cough incubation period, less side effects, and improving discomfort symptoms

Active Publication Date: 2022-05-27
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many kinds of drugs used clinically for acute cough relief, but many patients with chronic cough cannot obtain effective relief after being treated with these drugs

Method used

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  • Medicament for treating chronic cough as well as pharmaceutical composition, preparation method and application thereof
  • Medicament for treating chronic cough as well as pharmaceutical composition, preparation method and application thereof
  • Medicament for treating chronic cough as well as pharmaceutical composition, preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0046] Optionally, the medicament is a syrup, and the preparation method of the syrup includes:

[0047] Step S1: mixing the components in the pharmaceutical composition, and extracting by solvent extraction to obtain a total extract.

[0048] Step S2: mixing with the simple syrup to obtain a first mixture, wherein the simple syrup accounts for 50-70% of the total mass of the first mixture.

[0049] Further, the monosaccharide is made by mixing the monosaccharide with water, and boiling the monosaccharide under a slow fire to completely dissolve and form a slurry. Wherein, the monosaccharide includes but is not limited to: glucose, fructose, galactose, ribose and deoxyribose, optionally, the monosaccharide accounts for 55-65% of the total mass of the first mixture, more specifically 60%.

[0050] Furthermore, the first mixture is obtained after mixing the simple syrup with the total extract, and then the first mixture is mixed with sodium benzoate and ethyl paraben, wherein t...

Embodiment 1

[0070] The present embodiment provides a medicament for the treatment of chronic cough, and the pharmaceutical composition of the medicament is:

[0071] 23 parts of ebony, 13 parts of schisandra, 18 parts of mulberry, 17 parts of aster, 17 parts of perilla leaves, 7 parts of bitter almond, 4 parts of asarum, 13 parts of Ophiopogon japonicus, and 3 parts of licorice.

[0072] The preparation method of the medicament includes:

[0073] The medicinal materials in the above-mentioned pharmaceutical composition are mixed, boiled twice with water, and filtered to obtain a decoction.

Embodiment 2

[0075] The present embodiment provides a medicament for the treatment of chronic cough, and the pharmaceutical composition of the medicament is:

[0076] 20 parts of ebony, 10 parts of schisandra, 20 parts of salt mulberry, 15 parts of aster, 15 parts of perilla leaves, 10 parts of bitter almond, 3 parts of asarum, 10 parts of Ophiopogon japonicus, and 5 parts of licorice.

[0077] The preparation method of the medicament includes:

[0078] The medicinal materials in the above-mentioned pharmaceutical composition are mixed, decocted twice with water, the amount of water added for the first time is 10 times the amount of the drug, and the amount of water added for the second time is 8 times the amount of the drug, decocted for 1 hour each time, and combined the two decoctions. Boil the filtrate to get a decoction.

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Abstract

The invention provides a medicament for treating chronic cough as well as a pharmaceutical composition, a preparation method and application thereof, and belongs to the field of medicine research. The pharmaceutical composition comprises smoked plum, Chinese magnoliavine fruit, mulberry, tatarian aster root, perilla leaf, bitter apricot kernel, asarum, dwarf lilyturf tuber, raw licorice root and the like. The medicament is prepared by mixing and extracting the components in the pharmaceutical composition. The medicament and the pharmaceutical composition concurrently astringe lung and tonify lung, have the functions of dispersing and lowering lung qi and conditioning body fluid qi, and have good effects of astringing lung and relieving cough. The medicament and the pharmaceutical composition have obvious treatment effects on chronic cough, especially refractory chronic cough (cough hypersensitivity syndrome or idiopathic cough or unknown chronic cough), upper airway cough syndrome or eosinophilic bronchitis, gastroesophageal reflux cough and cough variant asthma; the traditional Chinese medicine composition can be used for preparing medicines for treating corresponding diseases of chronic cough, and has the advantages of quick effect and small side effect.

Description

technical field [0001] The present invention relates to the field of drug research, in particular, to a medicament for treating chronic cough and its pharmaceutical composition, preparation method and use. Background technique [0002] Cough is a common and frequently-occurring disease of the respiratory system, and it is a common complaint in respiratory clinics. Coughing itself is a defensive reflex activity produced when the respiratory system is stimulated. It helps to clear external stimuli and its own secretions from the airway. It is a beneficial action and is sometimes seen in healthy people. Under normal circumstances, mild and infrequent cough can be relieved naturally without the application of cough medicine. Long-term frequent or excessive cough is a pathological reaction, which will not only increase the pain of the patient, but also affect rest and sleep. Physical exhaustion, in severe cases, can also promote the development of the disease and produce other c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P11/14A61P11/06A61K35/64
CPCA61K36/736A61K36/79A61K36/57A61K36/605A61K36/28A61K36/535A61K36/268A61K36/8968A61K36/484A61K35/64A61K36/752A61K36/23A61K36/24A61P11/14A61P11/06A61K2300/00
Inventor 赖克方刘晓东钟山黄婉怡
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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