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Medicinal composition for preventing and treating bronchial asthma and preparation and application thereof

A technology of bronchial asthma and composition, which is applied in the field of traditional Chinese medicine and natural medicine, can solve the problems of insignificant clinical curative effect of Chinese patent medicine, and achieve the effects of reducing inflammatory cell infiltration in lung tissue, smooth muscle hyperplasia, and attack symptoms

Active Publication Date: 2012-01-25
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The clinical curative effect of Chinese patent medicine is not significant, and it is not accepted by doctors and patients

Method used

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  • Medicinal composition for preventing and treating bronchial asthma and preparation and application thereof
  • Medicinal composition for preventing and treating bronchial asthma and preparation and application thereof
  • Medicinal composition for preventing and treating bronchial asthma and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: the preparation of Chinese medicine extract

[0051]1. Weigh the crude drug according to the formula in Table 1

[0052] 2. Extraction:

[0053] Decoction: After mixing the crude drugs, add 13 times of water for the first time, boil for 1 hour, keep warm for 2 hours, and filter out the drug solution. After adding 11 times of water for the second time and boiling, keep it warm for 1 hour, and filter out the medicinal solution in 2 hours. The filtrates were combined and concentrated.

[0054] Alcohol precipitation: add 95% ethanol in an appropriate amount to reach an alcohol content of 63.3%, and refrigerate for 24 hours. Filter out and concentrate the filtrate to a liquid extract sample.

[0055] Table 1 (in the table, the measurement unit of all materials is g)

[0056] formula

Embodiment 2

[0057] Embodiment 2 pharmacodynamic research

[0058] 1. Preparation of modeling liquid

[0059] Sensitization solution: Dissolve 10g of OVA (ovalbumin) in 100ml of physiological saline to prepare a 10% concentration of sensitization solution, which is prepared before use.

[0060] Atomized stimulation solution: Dissolve 5g of OVA in 100ml of physiological saline to prepare a 5% concentration of the sensitization solution, which is prepared before use.

[0061] 2. Preparation of bronchial asthma model

[0062] Dissolving 10 g of OVA in 100 ml of physiological saline to prepare a sensitization solution with a concentration of 10%, sensitizes the mice by intraperitoneal injection to create a mouse model of bronchial asthma. Except for the blank control group, each mouse was sensitized by intraperitoneal injection of 1ml of 10% OVA saline solution on the 1st day and the 13th day; In a 5L airtight container, inhale 5% OVA saline for 40 minutes with an ultrasonic nebulizer to st...

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Abstract

The invention discloses a medicinal composition for preventing and treating bronchial asthma and preparation and application thereof. The traditional Chinese medicinal composition comprises the following crude medicine components of: fired ephedra, apricot, peach kernel, seed of peppertree pricklyash, earthworm and prepared liquorice. Experimental researches prove that: an extract or a medicinal preparation prepared from the medicinal composition can obviously lighten symptoms of a bronchial asthma model mouse, obviously improves airway inflammation of the bronchial asthma model mouse, lightens lung tissue inflammatory infiltration, reduces inflammatory exudation and lightens proliferation of smooth muscle, has the function similar to dexamethasone, and is expected to be developed into a novel medicine for preventing and treating the bronchial asthma according to the mechanism thereof.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and natural medicine, and specifically relates to a pharmaceutical composition for preventing and treating bronchial asthma and its preparation and application. Background technique [0002] Bronchial asthma belongs to the category of asthma in traditional Chinese medicine. At present, about 300 million people in the world suffer from this disease, and it is estimated that the total number of patients will increase to 400 million in the next 15 to 20 years. In recent years, the incidence of asthma in my country has been on the rise. The annual cost of asthma treatment in my country has exceeded 3 billion yuan, which has greatly affected people's normal life, seriously threatened people's physical and mental health, and wasted national resources. Therefore, the prevention and treatment of asthma has far-reaching significance. Because its etiology has not yet been elucidated, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/758A61P11/06A61K35/64A61K35/62
Inventor 朱慧华虞坚尔张晓峰江丽红
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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