Acute lung injury treating pharmaceutical composition

A technology of acute lung injury and composition, which is applied in the field of pharmaceutical composition for the treatment of acute lung injury, can solve the problems of lack of effective drugs and methods for the treatment of acute lung injury, and achieve the purpose of reducing pulmonary tissue edema and inflammatory cell exudation, protecting The effect is obvious and the effect of reducing the pathological score

Inactive Publication Date: 2018-09-25
王青雷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

ALI has a continuous process from mild to severe, and there is still a lack of effective drugs and methods for the treatment of acute lung injury

Method used

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  • Acute lung injury treating pharmaceutical composition
  • Acute lung injury treating pharmaceutical composition
  • Acute lung injury treating pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0021] The characterization of experimental example 1 medicine of the present invention

[0022]

[0023] 1 H NMR (400MHz, DMSOd6): δ8.80(s, 1H), 8.20(s, 1H), 7.41(s, 1H), 7.32(s, 1H), 4.49(dd, 1H), 4.36-4.23(m ,2H),3.73(t,2H),3.42-3.34(m,1H),3.35(s,3H),3.19(d,1H),1.60(td,1H),0.88(d,3H),0.71( d, 3H).

[0024] MS measured value (ESI+)[(M+H)+]: 392.

experiment example 2

[0025] Experimental example 2 Therapeutic effect of medicine of the present invention for acute lung injury

[0026] Grouping of Animals and Treatment Methods 72 healthy male SD rats were randomly divided into 4 groups, namely normal group, model group, dexamethasone group and drug group of the present invention, with 18 rats in each group.

[0027] Preparation of acute lung injury (ALI) rat model

[0028] The ALI model was prepared by LPS (lipopolysaccharide) exposed tracheal instillation. Except the normal group, the other groups were given intratracheal infusion of LPS (5 mg·kg -1 ) solution. Rats were treated with 3% sodium pentobarbital (30 mg·kg -1 ) anesthetized by intraperitoneal injection, fixed the supine position of the rat, cut the neck tissue in the middle of the aseptic operation, exposed the trachea, and instilled LPS solution from the trachea to the lung with a 1mL syringe, then stood the rat upright, rotated and shook it left and right. The LPS solution wa...

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Abstract

The invention belongs to the technical field of medicine, and specifically discloses an acute lung injury treating pharmaceutical composition, and uses of a compound having a structure represented bythe following formula defined in the specification in preparation of acute lung injury treating drugs, wherein R1, R2 and R3 can be the same or different groups. Patients with acute lung injury have pathological changes such as pulmonary alveolus structure destruction, pulmonary interstitial congestion and edema, massive inflammatory cell infiltration and the like. According to the present invention, the acute lung injury treating pharmaceutical composition can improve the symptoms of the patients with acute lung injury, reduce lung tissue edema and inflammatory cell exudation, and reduce thehistopathological score of lung tissue, wherein the longer the action time, the more significant the protection effect on lung.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating acute lung injury. Background technique [0002] Acute lung injury (ALI) is a clinical syndrome that occurs due to characteristic pathological changes in lung tissue structure caused by various reasons. Its pathological features are alveolar capillary endothelial cells and alveolar epithelial cell damage, manifested as extensive pulmonary edema and tiny atelectasis. The pathophysiological changes are mainly increased intrapulmonary shunt and decreased lung compliance. Clinically, hypoxemia, rapid respiratory rate, and diffuse infiltration of both lungs appeared on chest X-ray. ALI has a continuous process from mild to severe, and there is still a lack of effective drugs and methods for the treatment of acute lung injury. Contents of the invention [0003] The object of the present invention is to provide a pharmaceutica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4418A61P11/00
CPCA61K31/4418
Inventor 王青雷
Owner 王青雷
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