Application of O-(tetrahydropyrrole) ethyl derivative of cleistanone in preparation of medicines for preventing or treating pancreatic fibrosis

A technology of tetrahydropyrrolyl and ethyl derivatives, which can be used in drug combinations, medical preparations containing active ingredients, digestive systems, etc., can solve problems such as low safety and high toxicity, and achieve good resistance to pancreatic fibrosis. Effect
CN104147019AActive Publication Date: 2014-11-19JASAN BIO MEDICINE JIAXING CO LTD
1 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
JASAN BIO MEDICINE JIAXING CO LTD
Publication Date
2014-11-19

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to the fields of organic synthesis and medicinal chemistry and in particular relates to an O-(tetrahydropyrrole) ethyl derivatives of cleistanone, a preparation method of the O-(tetrahydropyrrole) ethyl derivative of cleistanone as well as application of the O-(tetrahydropyrrole) ethyl derivative of cleistanone in preparation of medicines for preventing or treating pancreatic fibrosis. A novel O-(tetrahydropyrrole) ethyl derivative of the cleistanone is synthesized, and the invention also discloses a preparation method of the O-(tetrahydropyrrole) ethyl derivative. The pharmacology experiment proves that the O-(tetrahydropyrrole) ethyl derivative of the cleistanone has an effect of preventing or treating the pancreatic fibrosis and has the value of developing the medicine for preventing or treating the pancreatic fibrosis.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to O-(tetrahydropyrrolyl)ethyl derivatives of cleistanone, a preparation method and uses thereof. Background technique

[0002] Pancreatic fibrosis is a common feature of chronic pancreatitis caused by various reasons, and it is also the accompanying histopathological feature, manifested as a large number of fibroblast proliferation and extracellular matrix rich in connective tissue. It is the result of pancreatic damage and repair due to various reasons. Recently, pancreatic stellate cells and various cytokines have been found to be related to pancreatic fibrosis. The incidence of pancreatic fibrosis is increasing. There is an urgent need to develop effective and low-toxic anti-pancreatic fibrosis drugs. .

[0003] The existing drugs for the treatment of pancreatic fibrosis have the problems of high toxicity and low safety. It is most important to find com...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More