Cleistanone O-(imidazolyl) ethyl derivative, and preparation method and application thereof

A technology of ethyl derivatives, cleistanone, applied in the field of preparation, O-ethyl derivatives of cleistanone, to achieve good anti-rhinitis effect
CN104402964AActive Publication Date: 2015-03-11NANJING UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV
Publication Date
2015-03-11

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Abstract

The invention relates to the fields of organic synthesis and pharmaceutical chemistry, in particular to a Cleistanone O-(imidazolyl) ethyl derivative, and a preparation method and application thereof in the preparation of anti-rhinitis drugs. The invention synthesizes a new Cleistanone O-(imidazolyl) ethyl derivative and discloses a preparation method thereof. Pharmacological experiments prove that the Cleistanone O-(imidazolyl) ethyl derivative has the effect of resisting to rhinitis and has the value of anti-rhinitis drug development.
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Description

technical field

[0001] The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to an O-(imidazolyl) ethyl derivative of Cleistanone, a preparation method and use thereof. Background technique

[0002] Rhinitis is a common clinical disease and frequently-occurring disease. The occurrence of rhinitis is mainly related to allergic reactions and belongs to the category of immune inflammation. At present, antihistamines such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used for the treatment of rhinitis. Therefore, small molecule compounds with clear composition, controllable quality, safety and high efficiency have potential value in the development of rhinitis treatment drugs.

[0003] It is of great value to find compounds or lead compounds from natural products and modify their structures to obtain their derivatives, so as to obtain potential drugs with high efficiency and low toxicity.

[0004] At p...

Claims

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