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36results about How to "Good anti-hepatic fibrosis effect" patented technology

Application of diethylamine derivatives of cleistanone cleistanone in the preparation of anti-hepatic fibrosis drugs

The invention relates to the fields of organic synthesis and medicinal chemistry, and in particular to a Cleistanone derivative, a preparation method and its application in the preparation of anti-hepatic fibrosis drugs. The present invention synthesizes a new Cleistanone derivative and discloses its preparation method. Pharmacological experiments show that the Cleistanone derivatives of the present invention have an anti-hepatic fibrosis effect, and have the value of developing anti-hepatic fibrosis drugs.
Owner:NANJING UNIV

Application of diethylamine derivative of Cleistanine in preparation of anti-hepatic fibrosis medicines

The invention relates to the field of organic synthesis and medicinal chemistry, in particular to a derivative of Cleistanine, a preparation method and application of Cleistanine in preparation of anti-hepatic fibrosis medicines. According to the invention, a novel Cleistanine derivative is synthesized and the invention discloses the preparation method thereof; the pharmacological experiments show that the derivative of Cleistanine has anti-hepatic fibrosis effect and value for developing anti-hepatic fibrosis medicines.
Owner:NANJING UNIV

Method for extracting C15H18O5 from Cichorium glandulosum Boiss.et Hout and application of C15H18O5

The invention relates to a method for separating and extracting C15H18O5 from Cichorium glandulosum Boiss.et Hout and use of C15H18O5 the English name of which is 11B, 13-Dihydrolacurin. The method is characterized by comprising the following steps: soaking the root of Cichorium glandulosum Boiss.et Hout by ethanol; collecting the percolate by a percolation method; obtaining a thick extract by a reduced pressure distillation device; passing the extract through a silicagel column, an octadecylsilyl column and a Sephadex LH-20 column; eluting; and drying the eluant by the reduced pressure distillation device to obtain dry powder which is the monomer C15H18O5, the English name of which is 11B, 13-Dihydrolacurin. The compound has the effect of preventing anti-hepatic fibrosis, namely, the compound inhibits activating and proliferating effect of hepatic stellate cells, so that the C15H18O5 with the English name of 11B, 13-Dihydrolacurin can be used as a lead compound for preventing anti-hepatic fibrosis.
Owner:SHIHEZI UNIVERSITY

Application of saikoside d in preparation of anti-hepatic fibrosis disease drugs

The invention discloses application of saikoside d in preparation of anti-hepatic fibrosis disease drugs, and belongs to the technical field of medicines. The invention aims to provide pharmacological activities exhibited by the saikoside d in treatment of hepatic fibrosis symptoms and related mechanisms. The saikoside d has a good anti-hepatic fibrosis effect, and the action mechanisms may be related with improvement of activities of superoxide dismutase, reduction of generation of oxyradical and inhibition of activation of TGF-beta 1 (transforming growth factor) signaling pathway.
Owner:SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Derivative composition of benzimidazole and dichloroethylamino of Psiguadial A for anti-hepatic fibrosis

The invention relates to the field of organic synthesis and drug chemicals. The invention discloses a composition prepared from O-(benzimidazole) ethyl derivative (III) and O-(dichloroethylamino) ethyl derivative (IV) of Psiguadial A according to mass ratio of 20: 80 and a preparation method of the composition by mixing above compounds according to mass ratio of 20: 80. The pharmacological experiment indicates that the composition provided by the invention can significantly inhibit the NIH / 3T3 propagation and fibroblast propagation induced by transforming growth factor-beta 1 when its content is 20 ug / ml, and the composition has the anti-hepatic fibrosis effect; therefore, the invention further provides the application of the composition prepared from O-(benzimidazole) ethyl derivative (III) and O-(dichloroethylamino) ethyl derivative (IV) of Psiguadial A according to mass ratio of 20: 80 in preparing the anti-hepatic fibrosis drugs.
Owner:苏州贺澳德生物医药科技有限公司

Composition and application thereof to anti-liver fibrosis medicament

The invention relates to the fields of organic synthesis and pharmaceutical chemistry, in particular to a composition, a preparation method and use of the composition in preparation of an anti-liver fibrosis medicament. The invention discloses a composition and a preparation method thereof. As proved by pharmaceutical experiments, the composition has an anti-liver fibrosis function and a value in developing the anti-liver fibrosis medicament.
Owner:NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH

Mdivi-1 nano long-circulating liposome as well as preparation method and application thereof

The invention discloses a nano long-circulating liposome, the liposome is formed by entrapment of a pharmaceutical active ingredient by a lipid membrane material, the pharmaceutical active ingredient is Mdivi-1, and the molar mass ratio of the Mdivi-1 to the lipid membrane material is 1: (80-20). The lipid membrane material comprises phospholipid, cholesterol and a long circulating material, and the long circulating material is preferably DSPE-mPEG2000. The Mdivi-1 nano long-circulating liposome provided by the invention is small in hepatotoxicity and few in side effects, has an obvious effect of improving hepatocyte injury compared with a free drug, and also has a better anti-hepatic fibrosis effect.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

Composition 67083001030512 and application of composition 67083001030512 to drug for resisting liver fibrosis

The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a composition 67083001030512, a preparation method of the composition 67083001030512, and application of the composition 67083001030512 to a drug for resisting liver fibrosis, and discloses the composition 67083001030512 and the preparation method. Pharmacological experiments show that the composition 67083001030512 plays a role in resisting liver fibrosis, thereby having a high value on development of the drug for resisting liver fibrosis.
Owner:苏州贺澳德生物医药科技有限公司

Compound traditional Chinese medicine for intervening hepatic fibrosis and preparation method and application thereof

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a compound traditional Chinese medicine for intervening hepatic fibrosis and a preparation method thereof. The compound traditional Chinese medicine consists of the following raw materials in parts by weight: 10 to 30 parts of lizard, 10 to 30 parts of radix angelicae sinensis, 10 to 20 parts of vinegar-processed radix bupleuri, 10 to 30 parts of raw radix paeoniae alba, 20 to 50 parts of raw rhizoma atractylodis macrocephalae, 10 to 30 parts of poria cocos, 10 to 30 parts of vinegar-processed turtle shell, 20 to 50 parts of radix salviae miltiorrhizae, 15 to 45 parts of radix paeoniae rubra, 10 to 30 parts of liquorice root, 20 to 50 parts of raw rice sprout, 20 to 40 parts of raw fructus crataegi, 10 to 30 parts of rhizoma corydalis, 10 to 30 parts of deer-horn glue, 20 to 50 parts of spina gleditsiae, 20 to 50 parts of lucid ganoderma, 10 to 30 parts of fructus lycii, 10 to 30 parts of fingered citron, and 10-30 parts of fructus mume. The compound preparation has a remarkable curative effect on hepatic fibrosis caused by deficiency of liver blood and stasis of veins.
Owner:NINGXIA MEDICAL UNIV

Application of benzimidazolyl and morpholinyl derivative composition of Atropurpuran to anti-hepatic fibrosis

The invention relates to the fields of organic synthesis and pharmaceutical chemistry. The invention discloses and provides a composition which is prepared from an O-(benzimidazolyl)ethyl derivative (III) and an O-(morpholinyl)ethyl derivative (IV) of Atropurpuran in a mass ratio of 65 to 35, and a method for preparing the composition by mixing the compounds in the mass ratio of 65 to 35. As proved by a pharmacology experiment, the composition provided by the invention can remarkably restrain NIH / 3T3 multiplication and fibroblast proliferation induced by transforming growth factor-beta1, and has an anti-hepatic fibrosis effect. The invention further provides application of the composition prepared by mixing the O-(benzimidazolyl)ethyl derivative (III) and the O-(morpholinyl)ethyl derivative (IV) of the Atropurpuran in the mass ratio of 65 to 35 to preparation of an anti-hepatic fibrosis medicament. (The composition is shown in the description.).
Owner:NANJING FUHAIAOSAI PHARMA CO LTD

Composition 77092202050623 and application thereof in anti-hepatic fibrosis drugs

The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a composition 77092202050623, a preparing method of the composition 77092202050623 and the application of the composition 77092202050623 in preparing anti-hepatic fibrosis drugs. Pharmacology experiments show that the composition 77092202050623 can resist hepatic fibrosis and can be used for developing anti-hepatic fibrosis drugs.
Owner:CHANGZHOU HIGH TECH RES INST OF NANJING UNIV

Derivative composition of imidazolyl and dihydroxyethylamino of Psiguadial A for anti-hepatic fibrosis

The invention relates to the field of organic synthesis and drug chemicals. The invention discloses a composition prepared from O-(imidazolyl)ethyl derivative (III) and O-(dihydroxyethylamino)ethyl derivative (IV) of Psiguadial A according to mass ratio of 15: 85 and a preparation method of the composition by mixing above compounds according to mass ratio of 15: 85. The pharmacological experiment indicates that the composition provided by the invention can significantly inhibit the NIH / 3T3 propagation and fibroblast propagation induced by transforming growth factor-beta 1 when its content is 20 ug / ml, and the composition has the anti-hepatic fibrosis effect; therefore, the invention further provides the application of thecomposition prepared from O-(imidazolyl)ethyl derivative (III) and O-(dihydroxyethylamino)ethyl derivative (IV) of Psiguadial A according to mass ratio of 15: 85 in preparing the anti-hepatic fibrosis drugs.
Owner:苏州贺澳德生物医药科技有限公司

Use of composition of triazolyl derivative and 1H-tetrazolyl derivative of Artalbic acid in preparation of anti-liver fibrosis medicines

The invention relates to the fields of organic synthesis and pharmaceutical chemistry, and discloses a composition composed of the O-(triazolyl)ethyl derivative and the O-(1H-tetrazolyl)ethyl derivative of Artalbic acid according to a mass ratio of 20:80, and a method for preparing the composition by mixing the O-(triazolyl)ethyl derivative and the O-(1H-tetrazolyl)ethyl derivative of Artalbic acid according to the mass ratio of 20:80. Pharmacologic experiments show that the composition can substantially inhibit NIH / 3T3 propagation and transforming growth factor-beta 1 induced fibroblast propagation at 20[mu] / ml, and has an anti-liver fibrosis effect. The invention also provides a use of the composition composed of the O-(triazolyl)ethyl derivative and the O-(1H-tetrazolyl)ethyl derivative of Artalbic acid according to a mass ratio of 20:80 in the preparation of the anti-liver fibrosis medicines.
Owner:南京海澳斯生物医药科技有限公司

Piperazinyl and dihydroxyethylamido derivative composition of Atropurpuran for anti-hepatic fibrosis

The invention relates to the field of organic synthesis and medicinal chemistry and discloses a composition composed of an O-(piperazinyl) ethyl derivative (III) and an O-(dihydroxyethylamido) ethyl derivative (IV) of Atropurpuran in a mass ratio of 70: 30 and a method of preparing the composition composed of the compounds in a mass ratio of 70: 30. A pharmacological experiment verifies that the composition provided by the invention can obviously inhibit NIH / 3T3 proliferation and fibroblast proliferation induced by a transforming growth factor-beta1 when the concentration of the composition is 20[mu]g / ml, and has the action of anti-hepatic fibrosis. Therefore, the composition provided by the invention also provides use of the composition composed of the O-(piperazinyl) ethyl derivative (III) and the O-(dihydroxyethylamido) ethyl derivative (IV) of Atropurpuran in the mass ratio of 70: 30 in preparing drugs for anti-hepatic fibrosis. The formula is as shown in the description.
Owner:NANJING FUHAIAOSAI PHARMA CO LTD

Application of composition of benzimidazolyl and bis(2-methylthioethyl) amino derivatives of Salviskinone A in anti-liver fibrosis drugs

The invention relates to the field of organic synthesis and medicinal chemistry and discloses a composition consisting of benzimidazolyl and bis(2-methylthioethyl) amino derivatives of Salviskinone A in a mass ratio of 55:45 and a method for mixing the compounds in a mass ratio of 55:45 to prepare the composition. Pharmacological experiments indicate that the composition provided by the invention in a concentration of 20mu g / ml can remarkably inhibit the NIH / 3T3 proliferation and the fibroblast proliferation induced by transforming growth factor-beta1, and realizes an anti-liver fibrosis effect; and therefore, the invention also provides an application of the composition consisting of benzimidazolyl and bis(2-methylthioethyl) amino derivatives of Salviskinone A in a mass ratio of 55:45 in preparing anti-liver fibrosis drugs.
Owner:NANJING FUHAIAOSAI PHARMA CO LTD

Application of composition of imidazolyl and dichloroethylamino derivatives of Atropurpuran to resistance of liver fibrosis

The invention relates to the field of organic synthesis and pharmaceutical chemistry and discloses application of a composition of imidazolyl and dichloroethylamino derivatives of Atropurpuran to resistance of liver fibrosis, namely a composition composed of an O-(imidazolyl) ethyl derivative (III) and an O-(dichloroethylamino) ethyl derivative (IV) of the Atropurpuran at the mass ratio of 70 to 30 and a method for preparing the composition by mixing the compounds at the mass ratio of 70 to 30. A pharmacology experiment shows that the composition provided by the invention can be used for remarkably inhibiting NIH / 3T3 proliferation and transforming growth factor-beta1 induced fibroblast proliferation when the concentration is 20mug / ml; the composition has the liver fibrosis resisting effect, so that the invention also provides application of the Atropurpuran to preparation of a medicine for resisting the liver fibrosis. (The formula (III) is shown in the description and the formula (IV) is shown in the description.).
Owner:NANJING FUHAIAOSAI PHARMA CO LTD

Composition and application of composition to anti-hepatic fibrosis drugs

The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method and application of the composition to preparation of anti-hepatic fibrosis drugs. Through pharmacological experiments, the composition has anti-hepatic fibrosis effect and has anti-hepatic fibrosis drug development value.
Owner:NANJING UNIV

Applications of composition of Schiglautone A derivatives in preparing medicines for resisting hepatic fibrosis

The invention relates to the fields of organic synthesis and pharmaceutical chemistry, and discloses and provides a composition prepared from O-(triazolyl) ethyl derivative (III) and O-(di(2-methylthio-ethyl)amino) ethyl derivative (IV) of Schiglautone A at the weight ratio of 70 to 30, and a method for preparing the composition by mixing the two compounds at the weight ratio of 70 to 30. The pharmacological experiment proves that the composition provided by the invention at 20 [mu] g / ml can obviously inhibit the proliferation of NIH / 3T3 and the proliferation of fibroblasts induced by transforming growth factor-beta 1, and has the effect of resisting hepatic fibrosis, and therefore, the invention further provides the applications of the composition prepared from O-(triazolyl) ethyl derivative (III) and O-(di(2-methylthio-ethyl)amino) ethyl derivative (IV) of Schiglautone A at the weight ratio of 70 to 30 in preparing medicines for resisting hepatic fibrosis.
Owner:NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH

Composition and application of composition in anti-hepatic-fibrosis medicine

The invention relates to the field of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method and an application of the composition in preparing anti-hepatic-fibrosis medicine, and discloses a composition and a preparation method thereof. Pharmacological experiments indicate that the composition has the function of resisting hepatic fibrosis, and has the value of developing the anti-hepatic-fibrosis medicine.
Owner:苏州贺澳德生物医药科技有限公司

Application of composition of tetrahydropyrrolyl and morpholinyl derivatives of Virosaine A in anti-liver fibrosis drugs

The invention relates to the field of organic synthesis and medicinal chemistry and discloses a composition consisting of tetrahydropyrrolyl derivatives and morpholinyl derivatives of Virosaine A in a mass ratio of 20:80 and a method for mixing the compounds in a mass ratio of 20:80 to prepare the composition. Pharmacological experiments indicate that the composition provided by the invention in a concentration of 20mu g / ml can remarkably inhibit the NIH / 3T3 proliferation and the fibroblast proliferation induced by transforming growth factor-beta1, and realizes an anti-liver fibrosis effect; and therefore, the invention also provides an application of the composition consisting of tetrahydropyrrolyl derivatives and morpholinyl derivatives of Virosaine A in a mass ratio of 20:80 in preparing anti-liver fibrosis drugs.
Owner:ZHENJIANG MAKERAO BIOPHARM TECH CO LTD

Composition and application thereof to hepatic fibrosis resistant medicines

The invention relates to the field of organic synthesis and medicinal chemistry and in particular relates to a composition, a preparation method and an application of the composition to preparation of hepatic fibrosis resistant medicines. The invention discloses the composition and the preparation method thereof. Pharmacological experiments show that the composition has the function of resisting hepatic fibrosis and has the value in developing the hepatic fibrosis resistant medicines.
Owner:NANJING FUHAIAOSAI PHARMA CO LTD

Application of Atropurpuran derivative composition in anti-hepatic-fibrosis medicine

The invention relates to the field of organic synthesis and medicinal chemistry and discloses and provides a composition formed by O-(tetrahydropyrrolyl) ethyl derivative (III) and O-(1H-tetranitroimidazolyl) ethyl derivative (IV) of Atropurpuran according to a mass ratio of 60:40 and a method of mixing the above compounds according to the mass ratio of 60:40 to prepare the composition. Pharmacological experiments show that the composition can remarkably inhibit NIH / 3T3 proliferation and transforming growth factor-beta 1 induced fibroblast proliferation when concentration is 20ug / ml and has anti-hepatic-fibrosis effect, so that the invention further provides application of the composition in preparing anti-hepatic-fibrosis medicine.
Owner:NANJING FUHAIAOSAI PHARMA CO LTD

Application of composition of Schiglautone A derivatives in preparation of anti-hepatic fibrosis drugs

The invention relates to the field of organic synthesis and medicinal chemistry and discloses and provides a composition composed of Schiglautone A O-(1H-tetrazole)ethyl and O-(benzimidazolyl)ethyl derivatives according to a mass ratio of 65:35. Pharmacological experiments show that the composition provided herein can significantly inhibit NIH / 3T3 proliferation and transforming growth factor-induced fibroblast proliferation and can resist hepatic fibrosis; therefore, the invention also provides application of a composition composed Schiglautone A O-(1H-tetrazole)ethyl and O-(benzimidazolyl)ethyl derivatives according to the mass ratio of 65:35, in the preparation of anti-hepatic fibrosis drugs.
Owner:NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH

Application of Harrisotone A O-(diethylamino)ethyl derivative and O-(piperazine) ethyl derivative composition to anti-hepatic fibrosis drug

The invention relates to the field of organic synthesis and pharmaceutical chemistry, and discloses a composition comprising a Harrisotone A O-(diethylamino)ethyl derivative (III) and an O-(piperazine) ethyl derivative (IV) according to the mass ratio of 65:35 and a method for preparing the composition by mixing compounds according to the mass ratio of 65:35. Pharmacological experiments indicate that the composition at a concentration of 20 microgram / ml can remarkably inhibit NIH / 3T3 proliferation and transforming growth factor-beta 1 induced fibroblast proliferation and has the function of resisting hepatic fibrosis, so that the invention further provides an application of the composition comprising the Harrisotone A O-(diethylamino)ethyl derivative (III) and the O-(piperazine) ethyl derivative (IV) according to the mass ratio of 65:35 to preparation of an anti-hepatic fibrosis drug.
Owner:NANJING GUANGKANGXIE BIOLOGICAL MEDICAL TECH

Compound traditional Chinese medicine for treating liver fibrosis

The invention discloses a compound traditional Chinese medicine for treating liver fibrosis, and relates to compound traditional Chinese medicines. The compound traditional Chinese medicine comprises,in weight percent, 0.5-2% of spina gleditsiae, 0.5-2% of stir-fried largehead atractylodes rhizomes, 0.5-2% of tangshen roots, 1-3% of membranous milkvetch roots, 0.5-1.5% of common peony roots, 0.5-1.5% of red-rooted salvia roots, 0.3-1% of Chinese angelica roots, 0.3-1% of peach seeds, 0.5-1.5% of turmeric rhizomes and 0.5-1.5% of vinegar turtle. The compound traditional Chinese medicine is prepared from conventional pharmaceutical excipients by a conventional method in the field of pharmacy. The compound traditional Chinese medicine for treating the liver fibrosis can be taken after beingdetected or extracted by water or ethyl alcohol. The medicine can be prepared into medically acceptable oral preparations such as tablets, capsules, granules and the like, and pharmacodynamical research shows that the medicine has the functions of invigorating spleen, supplementing qi, activating blood and dissolving stasis and is an effective and special medicine for treating liver fibrosis.
Owner:厦门市中医院 +1

Application of picroside I in preparation of medicine for preventing and treating hepatic fibrosis

The invention discloses an application of picroside I in preparation of a medicine for preventing and treating hepatic fibrosis. Researches show that picroside I can significantly reduce various components reflecting hepatic fibrosis in serum, reduce hepatocyte degeneration necrosis and inflammatory cell infiltration, effectively reduce accumulation of collagenous fibers in liver tissues, show anobvious liver protection effect, has a good anti-liver fibrosis effect, and has great application prospects.
Owner:SHANGHAI UNIV OF T C M
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