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Medicine composition for treating liver fibrillation and liver cirrhosis and its preparation process

A composition and technology of traditional Chinese medicine, applied in the field of pharmaceutical composition, can solve the problems of unsatisfactory cure rate, insignificant effective rate, and high long-term rebound, and achieve the effects of improving the body's immunity, obvious curative effect, and restoring liver function

Inactive Publication Date: 2006-03-15
姚希贤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The raw material formulations disclosed in these patents all use blood-activating and stasis-removing drugs and Qi-invigorating drugs. Although some curative effects have been obtained, the cure rate is still unsatisfactory, especially the long-term rebound is high. Due to the lack of clinical randomization, blind method and experimental pathological research , the actual efficiency is not obvious, nor is it sure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: the preparation of granule

[0039] Take these raw materials Chinese medicinal materials according to following consumption:

[0040] 50 grams of Danshen, 10 grams of Guiwei, 20 grams of Astragalus, 15 grams of Radix Paeoniae Rubra, 10 grams of fried Atractylodes macrocephala, 10 grams of Yunling, 10 grams of Chicken Neijin, 10 grams of Magnolia officinalis and 10 grams of Bupleurum;

[0041] Add water and decoct twice, the first time is 2-3 hours, the second time is 1-2 hours, filter, combine the filtrate, let it stand for clarification, evaporate at low temperature and concentrate to a thick paste, the specific gravity of the thick paste is thermally measured at 80-90°C 1.30-1.35;

[0042] Stir and mix the thick paste prepared above with powdered sugar and dextrin in an amount of 1:3:1. If necessary, add an appropriate amount of 60% ethanol to adjust the humidity to make a soft material, and use a granulator to squeeze through 11 mesh Sift into granule...

Embodiment 2

[0043] Embodiment 2: the preparation of powder

[0044] Take these raw materials Chinese medicinal materials according to following consumption:

[0045] 90 grams of Danshen, 20 grams of Guiwei, 30 grams of Astragalus, 20 grams of Radix Paeoniae Rubra, 10 grams of fried Atractylodes macrocephala, 10 grams of Yunling, 10 grams of Chicken Neijin, 10 grams of Magnolia officinalis and 10 grams of Bupleurum;

[0046] Dry and pulverize the gallinaceous gold into fine powder;

[0047] The remaining Chinese medicinal materials are dried and pulverized into fine powder;

[0048] The fine powder prepared above is mixed evenly to prepare.

Embodiment 3

[0049] Embodiment 3: the preparation of capsule

[0050] a) Take these raw Chinese medicinal materials according to the following dosages:

[0051] 160 grams of Danshen, 50 grams of Guiwei, 60 grams of Radix Astragali, 40 grams of Radix Paeoniae Rubra, 40 grams of Stir-fried Atractylodes Rhizome, 40 grams of Yunling, 40 grams of Chicken Neijin, 30 grams of Magnolia officinalis and 40 grams of Bupleurum;

[0052] b) Grinding the above medicinal materials into coarse powder, using 60% ethanol as a solvent to reflux extract at 70°C, after recovering ethanol, the extract is concentrated at low temperature to form a thick extract, dried, ground into fine powder, and packed into a hard capsule shell.

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PUM

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Abstract

The Chinese medicine composition for treating liver fibrillation and liver cirrhosis has active components prepared from red sage, astragalus root, other medicine(s) with function of promoting blood circulation to disperse blood clots, spleen invigorating medicine(s) and vital energy regulating medicine(s). The active comprises are matched with pharmaceutically acceptable carrier or excipient to prepare various preparation forms. The Chinese medicine composition has high practical curative rate in treating liver fibrillation, no recurrence and no toxic side effect.

Description

(1) Technical field [0001] The invention relates to a pharmaceutical composition, specifically a traditional Chinese medicine composition, which has the application of treating liver fibrosis and liver cirrhosis, and a preparation method of the traditional Chinese medicine composition. (2) Background technology [0002] Chronic liver disease (inflammation) is a common clinical disease and frequently-occurring disease. Hepatic fibrosis is an inevitable stage in the development of various chronic liver diseases (inflammation). Therefore, preventing and reversing the occurrence and development of liver fibrosis has become the focus of research. "Colchicine", D-penicillamine, pentoxifylline, and interferon have poor curative effects, large toxic and side effects, and are still difficult to apply clinically (refer to editor-in-chief Yao Xixian: "Clinical Gastroenterology" Tianjin Science and Technology Press 1999 , pp. 945-1009; Ruwart MT, Rush BD, SnyderKF, et al. 16, 16-Dimethy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/9066A61K36/899A61K36/89A61K35/64A61K36/71A61K35/38A61P1/16A61K35/57A61K35/62
Inventor 姚希贤
Owner 姚希贤
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