Application of picroside I in preparation of medicine for preventing and treating hepatic fibrosis

A technology of liver fibrosis and berberine, applied in the application field of medicine, can solve problems such as unsatisfactory

Inactive Publication Date: 2021-01-05
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, a large number of studies on the mechanism of liver fibrosis have deepened people's understanding of liver fibrosis, but there is no satisfactory drug to prevent the formation and progression of liver fibrosis in clinical practice.

Method used

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  • Application of picroside I in preparation of medicine for preventing and treating hepatic fibrosis
  • Application of picroside I in preparation of medicine for preventing and treating hepatic fibrosis
  • Application of picroside I in preparation of medicine for preventing and treating hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The effect of berberine Ⅰ in the treatment of liver fibrosis in mice:

[0026] 1. Reagents and materials

[0027] C57BL / 6 male mice, clean grade, body weight (20-22 g); berberine Ⅰ, produced by Nanjing Guangrun Biotechnology Co., Ltd.

[0028] 2. Experimental method

[0029] The animal experiment consisted of 4 groups, 12 animals in each group, randomly divided into blank group, model group, positive drug group and experimental group according to body weight. Thioacetamide (dissolved in normal saline, the same below) is a hepatic fibrosis-inducing drug, and the dosage is 200 mg / kg; S-adenosylmethionine is a positive drug, and the dosage is 10 mg / kg; Pirucetin Ⅰ is a candidate drug for anti-hepatic fibrosis, the dose is 75mg / kg. The mice in the blank control group were intraperitoneally injected with normal saline, and the mice in the model group, the positive drug group and the experimental group were injected with thioacetamide every other day for 8 weeks. At the s...

Embodiment 2

[0056] Preparation of a preparation of berberine I:

[0057] (1) Preparation of Pirutin I Granules:

[0058] Take appropriate amount of berberine Ⅰ, add appropriate amount of β-cyclodextrin, sucrose and soluble starch (mass ratio of berberine Ⅰ: dextrin: sucrose: soluble starch is 1:2:3:4), make soft material with ethanol, Make granules with a 16-mesh sieve, and dry below 60°C to obtain pubetroside I granules, which can be used for the treatment of liver fibrosis.

[0059] (2) Preparation of Pirucet I Tablets:

[0060] Weigh the prescription amount of berberine Ⅰ, starch, dextrin, tartaric acid and mix evenly. Add 50% ethanol drop by drop with a rubber dropper, and stir while adding until obvious particles appear. Use a 16-mesh sieve to granulate, dry at 60°C for 15 minutes, and then continue to use a 16-mesh sieve for sizing. Mix the prescribed amount of magnesium stearate with the whole granules evenly, and then press into tablets with a single-punch tablet machine, so t...

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PUM

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Abstract

The invention discloses an application of picroside I in preparation of a medicine for preventing and treating hepatic fibrosis. Researches show that picroside I can significantly reduce various components reflecting hepatic fibrosis in serum, reduce hepatocyte degeneration necrosis and inflammatory cell infiltration, effectively reduce accumulation of collagenous fibers in liver tissues, show anobvious liver protection effect, has a good anti-liver fibrosis effect, and has great application prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine and traditional Chinese medicine, and relates to a new medical application of berberine I, in particular to the application of berberine I in the preparation of medicines for preventing and treating liver fibrosis. Background technique [0002] Huhuanglian (Picrorhiza scrophulariiflora Pennell) is a perennial herb of Scrophulariaceae, a perennial herb with hairs. It is similar to the name of Coptis chinensis, and both of them are products of bitter cold, clearing away heat and dampness. They are good at removing dampness and heat in the stomach and intestines. Modern pharmacological studies have shown that Huhuanglian has the functions of protecting the liver, promoting gallbladder, and antifungal. The in-depth research on the hepatoprotective and choleretic effects of Huhuanglian is currently mainly focused on the total glycosides of Huhuanglian or Huhuanglian II. Picroside I (PicrosideI) is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/80A61P1/16
CPCA61K31/7048A61K36/80A61P1/16
Inventor 韩涵兰继平张彤熊凯石梦鸽金旻逸
Owner SHANGHAI UNIV OF T C M
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