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Method for extracting C15H18O5 from Cichorium glandulosum Boiss.et Hout and application of C15H18O5

A technology of C15H18O5 and chicory, which is applied in medical formula, medical preparations containing active ingredients, digestive system, etc.

Inactive Publication Date: 2014-05-21
SHIHEZI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

C 15 h 18 o 5 The English name is 11β, 13-Dihydrolacurin, which is currently blank

Method used

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  • Method for extracting C15H18O5 from Cichorium glandulosum Boiss.et Hout and application of C15H18O5
  • Method for extracting C15H18O5 from Cichorium glandulosum Boiss.et Hout and application of C15H18O5
  • Method for extracting C15H18O5 from Cichorium glandulosum Boiss.et Hout and application of C15H18O5

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: extract and isolate C from hairy chicory 15 h 18 o 5 English name 11B, the method of 13-Dihydrolacurin, proceed as follows:

[0027] a, the chicory root is dried in the air, and the moisture content is 1%, and the dried chicory root is taken, soaked for 36h with 3 times the amount of 60%% ethanol;

[0028] b. Adopt the percolation method, the ratio of chicory root and 60% ethanol is 1:10, flow rate: 1ml / min, and collect the percolation liquid;

[0029] c. The percolate is filtered once with a mesh with a pore size of 0.1 mm, and the filtrates are combined;

[0030] d. Use a vacuum distillation device, at a pressure of 1×10 -3 kPa, temperature: at 30°C, distill off ethanol to obtain a thick extract of 0.1g / ml;

[0031] e. Mix the thick extract and water at a ratio of 1:2 to obtain a mixed solution, extract with ethyl acetate equal to the volume of the mixed solution, separate the ethyl acetate layer, and distill and concentrate at a pressure of 0.1 MPa...

Embodiment 2

[0043] Embodiment 2: extract and isolate C from hairy chicory 15 h 18 o 5 English name 11B, the method of 13-Dihydrolacurin, proceed as follows:

[0044] a. Dry the chicory root with a water content of 10%, take the dried chicory root and soak it with 15 times the amount of 95% ethanol for 12 hours;

[0045] b, adopt percolation method, the ratio of chicory root and 95% ethanol is 1:50, flow rate: 5ml / min, collect percolation liquid;

[0046] c, the percolation liquid is filtered 5 times with a mesh with an aperture of 10mm, and the filtrates are combined;

[0047] d. Use a vacuum distillation device, at a pressure of 0.1×10 -3 kPa, temperature: at 80°C, distill off ethanol to obtain a thick extract of 0.4g / ml;

[0048] e. Mix the thick extract and water at a ratio of 1:10 to obtain a mixed solution, extract with an equal volume of ethyl acetate to the mixed solution, separate the ethyl acetate layer, and distill and concentrate at a pressure of 0.2 MPa and a temperature ...

Embodiment 3

[0060] Embodiment 3: extract and isolate C from hairy chicory 15 h 18 o 5 English name 11B, the method of 13-Dihydrolacurin, carries out according to the following steps:

[0061] a. Dry the chicory root with a moisture content of 5%, take the dried chicory root and soak it in 75% ethanol with 7 times the amount for 20 hours;

[0062] b. Adopt the percolation method, the ratio of chicory root and 80% ethanol is 1:25, the flow rate is 3ml / min, and the percolation liquid is collected;

[0063] c, the percolation liquid is filtered 3 times with a mesh with an aperture of 4mm, and the filtrates are combined;

[0064] d. Use a vacuum distillation device, at a pressure of 0.5×10 -3 kPa, temperature: at 55°C, distill off ethanol to obtain a thick extract of 0.3g / ml;

[0065] e. Mix the thick extract and water at a ratio of 1:5 to obtain a mixed solution, extract with ethyl acetate equal to the volume of the mixed solution, separate the ethyl acetate layer, and distill and concen...

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Abstract

The invention relates to a method for separating and extracting C15H18O5 from Cichorium glandulosum Boiss.et Hout and use of C15H18O5 the English name of which is 11B, 13-Dihydrolacurin. The method is characterized by comprising the following steps: soaking the root of Cichorium glandulosum Boiss.et Hout by ethanol; collecting the percolate by a percolation method; obtaining a thick extract by a reduced pressure distillation device; passing the extract through a silicagel column, an octadecylsilyl column and a Sephadex LH-20 column; eluting; and drying the eluant by the reduced pressure distillation device to obtain dry powder which is the monomer C15H18O5, the English name of which is 11B, 13-Dihydrolacurin. The compound has the effect of preventing anti-hepatic fibrosis, namely, the compound inhibits activating and proliferating effect of hepatic stellate cells, so that the C15H18O5 with the English name of 11B, 13-Dihydrolacurin can be used as a lead compound for preventing anti-hepatic fibrosis.

Description

technical field [0001] The invention relates to a method for extracting C 15 h 18 o 5 Process with the English name 11β,13-Dihydrolacurin and its use. Background technique [0002] Chicory root is the root of Cichorium glandulosum Boiss of Compositae plant hairy chicory (Cichorium glandulosum Boiss). The leaf bulbs or roots are edible or medicinal. It is native to the Mediterranean, Central Asia and North Africa, and is widely cultivated in Europe. In Europe, chicory is often used as a substitute for vegetables, pasture feed, sugar raw materials and coffee. Mainly distributed in my country's Xinjiang, Shandong, Inner Mongolia and other places. Chicory is a commonly used medicinal material of the Uyghur and Mongolian. It is called Kashenna in the Uyghur language. There is a record in the national standard of medicinal materials "Uyghur Medicine Chronicle": "Chicory can be used as medicine. It tastes slightly bitter, salty, and cool in nature. Uyghur medicine is widely ...

Claims

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Application Information

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IPC IPC(8): C07D307/93A61K31/365A61P1/16
Inventor 秦冬梅姚广民胡利萍张云生王新兵祝世发
Owner SHIHEZI UNIVERSITY
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