Mdivi-1 nano long-circulating liposome as well as preparation method and application thereof
A long-circulation liposome and long-circulation technology, which is applied in liposome delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as insoluble in water, short half-life, and large toxic and side effects, and achieve Improve liver cell damage, good anti-hepatic fibrosis, less side effects
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Embodiment 1
[0036] Liposomes were prepared using a thin-film hydration method using the method in reference [1]. Lecithin, cholesterol, DSPE-mPEG2000 and Mdivi-1 were dissolved in chloroform methanol solution (chloroform:methanol = 4:1 V / V) so that the concentration of lecithin was 7.5 mM, the concentration of cholesterol was 2 mM, and the concentration of DSPE-mPEG2000 was 0.5 mM , the concentration of Mdivi-1 was 0.125mM, and the film was formed by rotary evaporation under reduced pressure at 37°C in an eggplant-shaped flask; adding normal saline, hydrating at 37°C for 2 hours, and ultrasonicating on ice using a sonicator. Unencapsulated drug was then removed by centrifugation at 18000g for 3 minutes. Then filter with a 0.22 μm pore size filter to obtain Mdivi-1 nanometer long circulating liposomes.
Embodiment 2
[0038] The preparation method and raw materials are the same as those in Example 1, except that the concentration of Mdivi-1 in the chloroform methanol solution is 0.25 mM.
Embodiment 3
[0040] The preparation method and raw materials are the same as those in Example 1, except that the concentration of Mdivi-1 in the chloroform methanol solution is 0.5 mM.
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