Application of O-(piperazinyl) ethyl derivative of cleistanone to preparation of medicine for resisting erythrocyte hypoplastic anemia

A technology for low erythrocytosis and ethyl derivatives, which is applied in the field of preparation of O-ethyl derivatives of cylindrine, and can solve the problems of insufficient hematopoietic raw materials or utilization obstacles and the like
CN104288159AActive Publication Date: 2015-01-21冬青南京生物科技有限公司

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
冬青南京生物科技有限公司
Publication Date
2015-01-21

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Abstract

The invention relates to the fields of organic synthesis and pharmaceutical chemistry, in particular to O-(piperazinyl) ethyl derivative of cleistanone, and a preparation method and the application of the O-(piperazinyl) ethyl derivative to the preparation of medicine for resisting erythrocyte hypoplastic anemia. The invention compounds new O-(piperazinyl) ethyl derivative, and discloses a preparation method thereof. Pharmacology experiments show that the O-(piperazinyl) ethyl derivative has the effect of resisting erythrocyte hypoplastic anemia, and has the value of developing medicine for resisting erythrocyte hypoplastic anemia.
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Description

technical field

[0001] The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to O-(piperazinyl)ethyl derivatives of cleusenone, a preparation method and uses thereof. Background technique

[0002] There are different classifications of anemia based on different clinical features. Such as: acute and chronic anemia according to the progress of anemia; proliferative anemia (such as hemolytic anemia, iron deficiency anemia, megaloblastic anemia, etc.) and hypoplastic anemia (such as aplastic anemia) ).

[0003] Clinically, it is often classified from the pathogenesis and etiology of anemia:

[0004] 1. Hemorrhagic anemia

[0005] According to the rate of blood loss, it can be divided into acute and chronic, and chronic hemorrhagic anemia is often combined with iron deficiency anemia. It can be divided into coagulation diseases (such as idiopathic thrombocytopenic purpura, hemophilia and severe liver disease, etc.) and non-coagulation...

Claims

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