202 results about "1H-tetrazole" patented technology

The invention relates to a novel preparation method for (6R,7R)-3-[[(1-methyl-1H-tetrazole-5 radial)sulphur]methyl]-7-[(R)-2-(4-ethyl-2,3-dioxo-1-piperazine carbon amido)-2-p-hydroxyl phenyl-acetamido]-8-keto-5-thia-1-polyaza[4.2.0]octane-2-alkene-2-sodiumformate(cefoperazone sodium) shown as a formula (I). The formula (I) is shown in the specifications. The invention aims to provide a novel method for synthesizing a cefoperazone sodium compound. The method has the advantages of synthesis of TZA from 7-ACA (Acetic Acid) and 1-methyl-5-sulfydryl tetrazole, mild reaction condition, easiness for operating, one-step use of recyclable dimethyl carbonate serving as an environmentally-friendly solvent, great saving in the cost, high yields of products prepared in each step, good quality, low cost, high product purity and suitability for industrial production.

The invention relates to a method for preparing an antibacterial compound, in particular to a method for preparing a ceftezole sodium compound. The method comprises the following steps of: 1, synthesizing TZT II, and reacting 2-mercapto-1,3,4 thiadiazole and 7-aminocephalosporanic acid (ACA) to obtain TZT, wherein dimethyl carbonate is used as a reaction solvent; a boron trifluoride-dimethyl carbonate complex is used as a catalyst; after reaction, the agent used by adjusting pH of reaction liquid is sodium carbonate; the weight ratio of boron trifluoride to 7-ACA is 0.7 to 1.3; and 2, synthesizing anhydride I, namely reacting 1H-tetrazole-1-acetic acid and pivaloyl chloride to obtain anhydride; 3, synthesizing ceftezole III, namely reacting TZT II and anhydride I to obtain ceftezole; and 4, synthesizing ceftezole sodium IV, namely reacting ceftezole and sodium salt to obtain ceftezole sodium IV, wherein salt is sodium hydroxide.

The invention relates to a 1-(4-carboxy phenyl)-5-sulfydryl-1H-tetrazole and 4, 4'-bipyridyl blending cobalt composition and a preparation method thereof. The composition has a chemical formula as follows: {[Co(L)(4, 4'-bipy)(H2O)2](H2O)2}, wherein L=1-(4-carboxy phenyl)-5-sulfydryl-1H-tetrazole anion ligand; and 4, 4'-bipy=4, 4'-bipyridyl. The composition is prepared by adopting a diffusion method which is different from synthesizing methods, i.e. a hydrothemal method and the like, of a conventional cobalt metal carboxylic ligand blending composition reported in the traditional literature and overcomes the technical defects of high temperature, pressure and danger, low productivity, difficult purification and separation and poor repeatability; the synthesizing method showed by the invention has moderate condition, high productivity and good repeatability at normal temperature and pressure; and in addition, a magnetism test result of a crystal sample of the composition lays the theoretical foundation for further developing a novel magnetic-function molecular material.

The invention provides a cefminox sodium compound of a new route, in particular a method for producing the cefminox sodium compound. The method comprises a step of generating cefminox sodium through the reaction between 7beta-bromoacetamido-7a-methoxyl-3-(1-methyl-1H-tetrazole-5-S-methyl)-3-cephem-4-carboxylic acid and D-cysteine hydrochloride, and is characterized in that: the reaction condition of the step is that the reaction is performed in aqueous solution, sodium iodide is used as a catalyst, the pH value of the reaction system is between 7.5 and 8.0, and the reaction temperature is kept at 30+/-5 DEG C. Compared with the method for producing the cefminox sodium compound in the prior art, the method of the invention for producing the cefminox sodium compound greatly improves the product yield and the purity, and solves the problem that a cefminox sodium bulk drug always has a low purity in the prior art.

The invention relates to a liquid composition and an etching method therewith, wherein the liquid composition is used for etching copper contianing indium, gallium or zinc oxides or metal compounds with copper as main components. The etching method is cahracterized by contacting the liquid composition with the metal compound having copper or with copper as main components. The liquid composition includes A) H2O2; B) acid without fluorine atom; C) more than one from phosphonic acid, phsophates, 1H-tetrazole-1-acetic acid, 1H-tetrazole-5-acetic acid and 4-amino-1,2,4-triazole; and D) water, pH of hte composition is lwoer than 5. THe liquid composition can inhibit damage on teh indium, gallium or zinc oxides and etch copper on the oxides or the metal compounds with copper as main components.

The invention relates to a cefmetazole sodium compound and a synthetic method thereof, 7 Beta-amino-7 Alpha-methoxyl-3-(1-methyl-1H-tetrazole-5-sulfidomethyl)-3-cephem-4-benzyl carboxylate and cyanomethylthio acetic acid sodium are mixed and react in the presence of p-toluenesulfonyl chloride to generate cefmetazole; sodium hydroxide is added to obtain cefmetazole sodium. Compared with the prior art, the invention has the advantages of few reaction steps, high productive rate, high product purity and low cost of raw materials, and has a broad prospect.

The invention belongs to drug synthesis, particularly relates to the main ring of Sartan drug for the treatment of the hypertension i.e. 5-(4'-formyl biphenyl-2-base)-1H-tetrazole. The preparation method comprises the following procedures, bromination, esterification, cyclization, hydrolysis and oxidation. Utilizing the triethylamine hydrochloride to serve as the catalyst, the method of the invention inhibits the side reaction, promotes the purity and the yield of the product, avoids the residue of the poisonous matter in the drug intermediate, reduces the waste discharge, realizes the clean production and protects the environment.

A process for the preparation of a 5,5'-bi-1H-tetrazole diammonium salt by dropwisely adding the aqueous hydrogen peroxide to which a small amount of weakly acidic substance has been added, to a starting aqueous solution containing hydrogen cyanide or sodium cyanide or potassium cyanide, sodium azide and a catalytic amount of copper sulfate preferably at a low temperature to maintain the pH of the reaction solution over a range of from 5 to 6, heating the reaction solution to effect the oxidation and cyclization reaction, reacting the reaction product with ammonium chloride or an aqueous solution thereof, and recovering the formed ammonium salt in the form of sparingly soluble crystals. The desired product is obtained in a high yield and in a high purity from the starting materials which are cheaply available and are easy to handle through a decreased number of steps, i.e., through a one-pot reaction without requiring cumbersome after-treatment.

The invention provides a new preparation method of drug Pranlukast for treating asthma. The new preparation method includes the specific steps that with 2-aminophenol-4-sulfonic acid as a starting material, a key intermediate 3-amino-2-hydroxyacetophenone is prepared by means of acylation, Fries rearrangement and deprotection, then reacts with 4-(phenylbutoxy)benzoic acid, and then is subjected to condensation with ethyl 1H-tetrazole-5-acetate, and finally preparation is achieved through ring closing under the acidic condition. Compared with the prior art, the raw material used for the new preparation method is low in price and easy to obtain, industrialization of a process can be achieved easily, and the obtained final product is high in purity; and no dangerous process exists, equipment is simple, and the route is novel.

A process for the preparation of a 5,5'-bi-1H-tetrazole diammonium salt by using dicyan, sodium azide, ammonium chloride and water as a reaction medium. This process is industrially advantageous since the 5,5'-bi-1H-tetrazole diammonium salt is synthesized and, then, the precipitated crystals thereof are simply isolated by filtration to obtain the 5,5'-bi-1H-tetrazole diammonium salt maintaining an yield which is not lower than 90%. The 5,5'-bi-1H-tetrazole diammonium salt is a gas-generating agent for air bags, which is lowly toxic and is easy to handle.

Reducing inhibition of the photochemical crosslinking by including in the photosensitive polyimide precursor composition a metal inhibitor selected from 1H-tetrazole, 1,2-cyclohexenediamine tetraacetic acid hydrate and 5-mercaptobenzimidazole.

The invention relates to 1,2,5-trisubstituted 1,2-dihydroindazol-3-ones of formula (I)whereinX is -SO2-, -SO-, -(CH2)p-, -(CH2)p-O-, -(CH2)p-(C=O)-, -(CH2)p-(C=O)-NH-, -(CH2)p-CHOH-, -CHOH-(CH2)p-, -(CH2)p-CH=CH-, -CH=CH-(CH2)p-,Y is -(C=O)-, -(C=O)-NH-, -(C=O)-NH-(CH2)p-, -C=O)-(CH2)p-, -(CH2)p-, -(CH2)p-O-, -(CH2)p-(C=O)-, -(CH2)p-(C=O)-NH-, -(CH2)p-(C=O)-NH-(CH2)p-, -(CH2)p-CHOH-, -CHOH-(CH2)p-, -(CH2)p-CH=CH-, -CH=CH-(CH2)p-,Z is -O-, -O-(CH2)p-, -NH-, -NH-(C=O)-, -NH-(C=O)-NH-, -NH-(C=O)-O-, -NH-CH2-(C=O)- and -NH-(C=O)-CH2-,P is a cardinal number from 1 to 4,R1, R2 and R3 can be the same or different and are:mono-, bi- or tricyclic saturated or mono- or polyunsaturated carbocycles having from 5 to 14 ring members; or mono-, bi- or tricyclic saturated or mono- or polyunsaturated heterocycles having from 5 to 15 ring members and from 1 to 6 heteroatoms,in which the carbocycles and the heterocycles can be mono- or polysubstituted by:C1-6-alkyl, -O-C1-6-alkyl, -O-C3-7-cycloalkyl, mono-, bi- or tricyclic saturated or mono- or polyunsaturated carbocycles having from 3 to 14 ring members, mono-, bi- or tricyclic saturated or mono- or polyunsaturated heterocycles having from 5 to 15 ring members and from 1 to 6 heteroatoms,R1 is also H, provided that when X is CH2, then R1 is not H,R3-Z is also NO2,and their pharmaceutically acceptable salts,but excluding compounds of formula (I) in whichif Z is -NH-(C=O)-, -NH-(C=O)-NH-, -NH-(C=O)-O-, -NH-(C=O)-CH2 and at the same time R1 is phenyl, monosubstituted or polysubstituted by -COOH, -COOC1-6-alkyl, -(CH2)p-COOH, -(CH2)p-COOC1-6-alkyl -CONHC1-6-alkyl, -CONHC6-14-aryl, -CONHSO2C1-6-alkyl, -CONHSO2C6-4-aryl, 1H-tetrazol-5-yl, then R2 is not phenyl, monosubstituted or polysubstituted by CN, halogen, C1-4-alkyl, C1-4-alkyloxy, CF3; andif R3-Z is NO2, then R1-X is not benzyl or 4-methoxybenzyl, and R2-Y is not benzyl or 2-picolyl at the same time; and to pharmaceutical treatment processes, and processes for making.

This invention relates to novel crystalline forms of valsartan, namely Form A, Form B, Form C, Form D and their solvates thereof. Processes for the preparation of the novel forms are also provided. The present invention further relates to novel processes for preparing a stable amorphous form of valsartan, and in this connection, to the amorphous form of valsartan produced by such processes. The present invention also discloses a novel process for obtaining stable Form I crystals of valsartan.

The invention relates to a synthetic method of cefazolin acid. According to the synthetic method, 7-aminocephalosporanic acid is taken as a raw material, and is reacted with 1H-tetrazole-1-acetic acid in a solvent so as to obtain an intermediate; the intermediate is reacted with 5-mercapto-1-methyltetrazole under base catalysis at solution states without crystallization, washing, and drying so as to obtain cefazolin acid. One-pot method is adopted; the synthetic method is simple; solvent application amount is low; environmental pollution is low; product yield is high; cost is low; and the synthetic method is suitable for industrialized production.

The invention relates to the use of compounds comprising at least one 2-(1H-tetrazol-5-yl)pyridine unit, of formula (I) below:

as ligands for lanthanides and, more especially, as organic chromophores for complexing these elements.

It also relates to lanthanide complexes using these compounds as complexing organic chromophores, and to new compounds containing one or more 2-(1H-tetrazol-5-yl)pyridine units, which are useful as ligands for lanthanides and, in particular, as organic chromophores for complexing these elements.

Applications: photonics and optoelectronics, especially for forming light-emitting devices such as electroluminescent diodes; biology, as for example for the preparation of luminescent probes.

The invention discloses a method for synthesizing cefotiam. The method comprises the following steps of: reacting acetonitrile, 7-aminocephalosporanic acid and 1- (2-bimethylaminoethyl)-1H-5-mercapto-tetrazole raw materials to obtain a 7-amino-3-[1-(2-bimethylaminoethyl)-1H-tetrazol-5-yl)thiomethyl]cefozopran dihydrochloride; reacting the product with pure water and isopropanol, decoloring the product of the reaction to obtain 7-amino-3-[1-(2-bimethylaminoethyl)-1H-tetrazole-5-yl)thiomethyl]cefozopran hydrochloride; reacting the compound and processing the product of the reaction to obtain formylamino cefotiam; reacting formylamino cefotiam with isopropanol, pure water and hydrochloric acid to obtain coarse cefotiam; and refining twice to obtain finished cefotiam. The method has the advantages that the prepared cefotiam is white powder and the cefotiam yield is as high as 33%; and the method is suitable for industrial production application.

The invention relates to a preparation method of a ceftezole and a midbody thereof. The midbody 7-amido-3-(1, 3, 4-thiadiazole-5-base) sulfidomethyl-2-cephem-2-carboxylic acid is prepared from 5-hydrosulphonyl-1, 3, 4-thiadiazole and 7-ACA under certain reaction environment; the prepared midbody 7-amido-3-(1, 3, 4-thiadiazole-5-base) sulfidomethyl-2-cephem-2-carboxylic acid reacts with 1H-tetrazole-1-acetyl chloride to prepare the ceftezole. The ceftezole can be prepared with a one-boiler method in the invention, and the preparation method has the advantages of short reaction time, gentle reaction condition, low cost and suitability of industrial production. In addition, the ceftezolet and the midbody produced by the method have high yield and good purity.

The invention discloses a Cd(II) metal organic framework material based on 5-(4-[1,2,4]triazole-1-phenyl)-1H-tetrazole, a preparation method and application thereof. The metal organic framework material is prepared by taking 5-(4-[1,2,4]triazole-1-phenyl)-1H-tetrazole and CdCl2.2.5H2O as raw materials througha solvothermal method; the molecular formula of the metal organic framework is [Cd(L)2(H2O)2]n, wherein L is a ligand 5-(4-[1,2,4]triazole-1-phenyl)-1H-tetrazole; and when the metal organic framework material is used for the detection of nitrobenzene (NB), acetone (ACE), iron ions (Fe<3+>)and dichromate ions (Cr2O7<2->) as a fluorescent sensing material, high sensitivity is shown.

The invention discloses a preparation method for a flexible metal organic frame material. The method comprises the following steps: (1) mixing N,N-dimethylformamide, ethyl alcohol, and water to form mixed liquid, and adding fluoroboric acid to form a mixed solvent; (2) adding cobalt-nitrate hexahydrate, 4,4'-dipyridyl, and 4-(1H-tetrazole-5-yl) benzoic acid to the mixed solvent, and stirring to form a mixture; (3) placing the mixture in a high-pressure reaction kettle, heating in a closed space, cooling to the room temperature, to obtain reaction liquid; (4) filtering the reaction liquid to obtain a filtrated body, and washing the filtrated body by using the ethyl alcohol, to obtain a pink rodlike crystal; and (5) activating the pink rodlike crystal, to obtain the flexible metal organic frame material. The flexible metal organic frame material is used for adsorbing and separating CO2 and CH4. The disclosed flexible metal organic frame material and the preparation method and the application thereof have the advantages of the simple and convenient preparation technology, the moderate reaction conditions, the easily obtained raw materials, and the good adsorptive selectivity and so on.

The invention relates to the field of medicines relative to hyperuricemia and gout, particularly to an inhibitor for a urate transporter 1 in a nitro containing and halogen benzene substituted 1H-tetrazole-1-acetic acid structure, a preparation method of the urate transporter 1, a medicine composition containing the inhibitor, and the application of the inhibitor in preparing diabetes medicines. The general formula (refer to the Specification) of the compound is disclosed by the invention, wherein X is selected from halogen substituent.