A WS2-PVP nanometer sheet, a preparing method thereof and applications of the nanometer sheet

A WS2-PVP, nanosheet technology, which is applied in chemical instruments and methods, general/multifunctional contrast agents, pharmaceutical formulations, etc., can solve the problems that the morphology of nanosheets cannot be effectively controlled, and the synthesis and surface modification processes are complicated. Achieve excellent photothermal conversion effect, improve colloidal stability, and achieve significant technological progress.

Inactive Publication Date: 2016-11-09
UNIV OF SHANGHAI FOR SCI & TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a WS 2 -PVP nano sheet and its preparation method and application, described this WS 2 -PVP nanosheets and their preparation method and application will solve the problem of WS in the prior art 2 - The synthesis and surface modification process of PVP nanosheets is very complicated, and the morphology of nanosheets cannot be effectively controlled.

Method used

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  • A WS2-PVP nanometer sheet, a preparing method thereof and applications of the nanometer sheet
  • A WS2-PVP nanometer sheet, a preparing method thereof and applications of the nanometer sheet
  • A WS2-PVP nanometer sheet, a preparing method thereof and applications of the nanometer sheet

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Embodiment 1

[0028] Weigh 0.15 g of ammonium tetrathiotungstate and 0.15 g of PVP (molecular weight: 360 kDa), mix with 30 N,N-dimethylformamide, and stir at room temperature for 1 hour to obtain a clear and transparent solution. The resulting solution was transferred to a 100 mL volume stainless steel reaction kettle lined with p-polyphenylene and sealed. The reactor was placed in a high-temperature oven for heat treatment at 220 °C for 12 h. After naturally cooling to room temperature, the reaction mixture was centrifuged (10,000 r / min, 5 min), and washed three times with 50% ethanolamine solution and distilled water. Observe the microscopic morphology of the material by TEM: Disperse an appropriate amount of nanosheets in absolute ethanol, and after the ultrasonic dispersion is uniform, immerse the copper mesh coated with carbon film in the above absolute ethanol. After the samples were naturally dried, they were observed and photographed by TEM, and the operating voltage of TEM was 200 k...

Embodiment 2

[0037] The valence of W and S elements in the nanosheets was characterized by ESCAlab250 X-ray photoelectron spectrometer (XPS) of Thermal Scientific Company. The excitation source is monochromator Al Kα X-rays (λ = 0.8339 nm), the energy is 1486 eV, the line width is 0.9 eV, and the power is 150 W. The binding energy was corrected with the 1s peak of C (284.8 eV). The crystal structure of the XRD diffraction pattern of the nanosheets was investigated using XRD (Rigaku D / max-2200PC, Japan). With Cu2Kα rays as the light source, the operating voltage is 40 kV, the current is 200 mA, and the scanning angle (2θ) ranges from 3° to 70°. WS using FTIR (Nicolet Nexus 670 infrared spectrometer) 2 -PVP nanosheet characterization, take a little WS 2 - PVP nanosheet powder and PVP powder (control group), mixed with dry KBr powder, ground evenly and then pressed into tablets. Placed on the Nicolet Nexus 670 infrared spectrometer sample holder for scanning (scanning range 400-4000cm -1...

Embodiment 3

[0040] The particle size of the characterized nanosheets in different dispersion media and their zeta potential in water were measured using Zetasizer Nanoseries (Nano ZS90) from Malvern, UK. Figure 4 (a), (b) and (c), it can be seen that after dispersing in deionized water, saline and 1640 cell culture medium for 72 h, PVP with a molecular weight of 2100 kDa mediated WS 2 -PVP nanosheets are less stable than colloids with a molecular weight of 30kDa and 360kDa, and the PVP-mediated synthesis of WS with a molecular weight of 30kDa and 360kDa 2 -The hydration kinetic diameter of PVP nanosheets does not change significantly, and has good colloidal stability (such as obvious Tyndall effect ( Figure 4 (d-f)), and is still a stable colloid ( Figure 4 g (left: PVP30kDa, middle: PVP360kDa, right: PVP2100kDa), laying the foundation for evaluating their photothermal conversion and tumor killing abilities at the in vivo level. WS synthesized mediated by different molecular weight P...

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Abstract

A WS2-PVP nanometer sheet is provided. The surface of a WS2 nanometer sheet is modified with polyvinylpyrrolidone. The invention also provides a preparing method of the WS2-PVP nanometer sheet. The method includes dissolving a sulfur source and a tungsten source into a solvent, stirring to fully dissolve the sources, dissolving a polymer into the solution of the sulfur source and the tungsten source under stirring to obtain a mixed solution of the sulfur source, the tungsten source and the polymer, transferring the prepared solution to a stainless steel reaction kettle having a poly(p-phenylene) liner, reacting under a sealed condition for a certain period of time, centrifuging for separation, and cleaning the prepared product the is the two-dimensional WS2-PVP nanometer sheet the surface of which is modified with the polymer and which has good colloid stability. The invention also provides applications of the WS2-PVP nanometer sheet as a photo-thermal conversion material. The nanometer sheet has excellent photo-thermal conversion, computed tomography and photoacoustic imaging capabilities, and is expected to be used for efficient cooperative diagnosis and treatment for tumor.

Description

technical field [0001] The invention belongs to the field of biological nanomaterials, and specifically relates to a simple and efficient ultra-small WS 2 -PVP nanosheets and their preparation methods and applications. Background technique [0002] Photothermal conversion materials, including inorganic materials such as tungsten oxide nanowires, copper sulfide nanoparticles, carbon nanomaterials (such as graphene) and noble metal nanomaterials (such as gold nanorods, palladium nanosheets), organic materials such as organic compounds / polymeric Drugs (such as indocyanine green, polypyrrole nanoparticles), etc., have been used in the research of photothermal therapy of tumors. Under the irradiation of near-infrared laser (NIR, wavelength range: 700-1100 nm), the above-mentioned photothermal materials enriched in tumor tissue can absorb and convert NIR into heat, which can locally heat up tumor tissue and lead to tumor ablation and death. thereby killing tumor cells. Howeve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00A61K47/48A61K49/04A61K49/22C01G41/00
CPCA61K41/0052A61K49/0002A61K49/04A61K49/221C01G41/00C01P2002/72C01P2002/82C01P2004/04C01P2004/62
Inventor 王世革胡飞赵九龙黄明贤高云邹多武
Owner UNIV OF SHANGHAI FOR SCI & TECH
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