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A kind of ultra-small mos2 nanosheet and its preparation method and application

A nanosheet and sheet diameter technology, applied in the field of ultra-small MoS2 nanosheets and their preparation, can solve problems such as poor tumor effect, achieve excellent colloidal stability, reduce non-specific phagocytosis, and improve photothermal conversion ability.

Inactive Publication Date: 2019-03-05
UNIV OF SHANGHAI FOR SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] For the above technical problems in the prior art, the invention provides a kind of ultra-small MoS2 nanosheet and its preparation method and application, described this ultra-small MoS2 nanosheet and its preparation method and application will solve the problems in the prior art Surface Modification of Tumor Cell Targeting Ligand MoS 2 The technical problem of the poor effect of nanosheet photothermal therapy on tumor

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  • A kind of ultra-small mos2 nanosheet and its preparation method and application
  • A kind of ultra-small mos2 nanosheet and its preparation method and application
  • A kind of ultra-small mos2 nanosheet and its preparation method and application

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Embodiment 1

[0029] Weigh 0.15g of PVP (molecular weight: 30kDa), mix with 30 mL of distilled water, and stir at room temperature for 1 hour to obtain a clear and transparent solution. Weigh 0.15 g of ammonium tetrathiomolybdate, mix it with the above PVP solution, and continue stirring at room temperature for 1 h to obtain a clear and transparent solution. The resulting solution was transferred to a 100 mL volume stainless steel reaction kettle lined with p-polyphenylene and sealed. The reactor was placed in a high-temperature oven for heat treatment at 220 °C for 12 h. After cooling to room temperature naturally, the reaction mixture was centrifuged and washed five times with 50% ethanolamine solution and distilled water respectively to obtain ultra-small MoS 2 Nanosheets. Observe the microscopic morphology of the material by TEM: Disperse an appropriate amount of nanosheets in absolute ethanol, and after the ultrasonic dispersion is uniform, immerse the copper mesh coated with carbon f...

Embodiment 2

[0032] The valences of Mo and S elements in the nanosheets were characterized by ESCAlab250 X-ray photoelectron spectrometer (XPS) from Thermal Scientific Company. The excitation source is monochromator Al Kα X-rays (λ = 0.8339 nm), the energy is 1486 eV, the line width is 0.9 eV, and the power is 150 W. The binding energy was corrected with the 1s peak of C (284.8 eV). The crystal structure of the XRD diffraction pattern of the nanosheets was investigated using XRD (Rigaku D / max-2200 PC, Japan). With Cu2Kα rays as the light source, the operating voltage is 40kV, the current is 200 mA, and the scanning angle (2θ) ranges from 3° to 70°. Using FTIR (Nicolet Nexus 670 infrared spectrometer) and UV-Vis-NIR (Lambda 25, Perkin Elmer Company, USA) to study ultra-small MoS 2 Nanosheet characterization. For FTIR characterization, take a few ultra-small MoS 2 Nanosheet powder and PVP powder (control group), mixed with dry KBr powder, ground evenly and then pressed into tablets. Pla...

Embodiment 3

[0036] Ultra-small MoS 2 Nanosheets and ordinary MoS 2 The nanosheets were dispersed in the wells of a 96-well cell culture plate to obtain suspensions with different Mo concentrations (e.g. Figure 4 shown), distilled water was used as a control. use as Figure 4 Ultra-small MoS irradiated by near-infrared laser light with a wavelength of 808 nm at the listed pre-set power 2 Nanosheets, ordinary MoS 2 Nanosheet dispersion or distilled water, record the temperature change of the material dispersion or distilled water with time and the corresponding infrared thermal imaging photos through the FLIRE60 infrared thermal imaging camera.

[0037] From Figure 4 It can be seen that the ultra-small MoS 2 Nanosheets and normal MoS 2 Nanosheets show different thermal conversion capabilities. High concentration of MoS 2 Nanosheets can more effectively convert light to heat to increase water temperature ( Figure 4 (a,b)). At the same material concentration, the higher the appl...

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Abstract

The invention discloses an ultra-small MoS2 nanosheet. The surface of the MoS2 nanosheet is modified with polyvinylpyrrolidone, and the diameter of the modified MoS2 nanosheet ranges from 15 nm to 25 nm. The invention further discloses a preparation method of the ultra-small MoS2 nanosheet. The preparation method comprises the following steps: a sulfur source and a molybdenum source are dissolved in water and stirred until the resources are completely dissolved; polyvinylpyrrolidone is dissolved in the solution of the sulfur source and the molybdenum source; the solution is transferred into a stainless steel reaction kettle with a polyphenyl lining for closed reaction, a reaction product is washed with an ethanolamine water solution and distilled water, and the ultra-small MoS2 nanosheet with the surface modified with polyvinylpyrrolidone is obtained. The invention further provides an application of the ultra-small MoS2 nanosheet as a photo-thermal conversion material. The ultra-small MoS2 nanosheet has good colloid stability, photo-thermal conversion capacity and photo-acoustic imaging capacity and has broad application prospect in the fields of tumor treatment and the like.

Description

technical field [0001] The invention belongs to the field of biological nanomaterials and relates to a kind of MoS 2 nanosheets, specifically an ultrasmall MoS 2 Nanosheets and their preparation methods and applications. Background technique [0002] Photothermal ablation of tumors is a novel minimal / non-invasive tumor treatment method that has emerged in recent years. Photothermal ablation of tumors uses near-infrared laser (NIR, wavelength range: 700-1100 nm) to irradiate photothermal materials enriched in tumor tissue. Ablation of death, thereby killing tumor cells. NIR has good biological tissue penetration, small light absorption and attenuation, and almost no damage to normal biological tissues. These advantages make photothermal therapy of tumors show a good application prospect. [0003] The prerequisite for near-infrared light to play a therapeutic role in living organisms is the need for nanomaterials that can absorb and convert near-infrared light into heat. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/32A61P35/00B82Y40/00A61K49/22
CPCA61K41/0052A61K47/32A61K49/222B82Y40/00
Inventor 王世革赵九龙黄明贤胡飞李貌邹多武
Owner UNIV OF SHANGHAI FOR SCI & TECH
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