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A kind of core shell structure nanocapsule and its preparation method and application

A technology of nanocapsules and core-shell structure, applied in the direction of microcapsules, capsule delivery, nanocapsules, etc., to achieve good colloidal stability, significant technological progress, and easy-to-obtain products

Active Publication Date: 2019-12-24
UNIV OF SHANGHAI FOR SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Up to now, there is no one-step realization of WS coated with Fe-based nanoparticles by solvothermal method. 2 Synthesis of nanomaterials and simultaneous surface modification literature or patent reports

Method used

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  • A kind of core shell structure nanocapsule and its preparation method and application
  • A kind of core shell structure nanocapsule and its preparation method and application
  • A kind of core shell structure nanocapsule and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Weigh 0.15 g ammonium tetrathiotungstate, 0.30 g PVP (molecular weight: 360 kDa) and 0.15 g ferric chloride hexahydrate, mix with 30 mL N,N-dimethylformamide, stir at room temperature for 30 minutes to obtain orange solution. The resulting solution was transferred to a 100 mL stainless steel reaction vessel lined with p-polyphenylene and sealed. The reactor was placed in a high-temperature oven for heat treatment at 220 °C for 12 h. After cooling down to room temperature naturally, the reaction mixture was centrifuged (12000 r / min, 5 min), and washed once and three times with 50% ethanolamine solution and distilled water respectively. , to get the product Fe 3 o 4 @WS 2 -PVP nanocapsules.

Embodiment 2

[0031] Get the Fe prepared in a little embodiment 1 3 o 4 @WS 2 -PVP nanocapsules, observe the microscopic appearance of the material through TEM: disperse an appropriate amount of nanocapsules in absolute ethanol, and after ultrasonically dispersing evenly, immerse the copper mesh coated with carbon film in the above-mentioned absolute ethanol. After the samples were dried naturally, they were observed and photographed by TEM (the operating voltage of TEM was 200 kV). It can be seen from Figure (1) that the material structure obtained in Example 1 is an elliptical nanocapsule structure composed of a two-dimensional layered structure and zero-dimensional nanoparticles.

Embodiment 3

[0033] Get respectively the Fe prepared in a little embodiment 1 3 o 4 @WS 2 -PVP nanomaterials, analysis of its composition and structure. The valences of W, S and Fe elements in the nanocapsules were characterized by ESCAlab250 X-ray photoelectron spectrometer (XPS) from Thermal Scientific. The excitation source is monochromator Al Kα X-rays (λ = 0.8339 nm), the energy is 1486 eV, the line width is 0.9 eV, and the power is 150 W. The binding energy was corrected with the 1s peak of C (284.8 eV). The crystal structure of the XRD diffraction pattern of the nanocapsules was investigated using XRD (Rigaku D / max-2200PC, Japan). With Cu2Kα rays as the light source, the operating voltage is 40kV, the current is 200 mA, and the scanning angle (2θ) ranges from 3° to 70°. Characterization of Fe before and after drug loading using FTIR (Nicolet Nexus 670 infrared spectrometer) 3 o 4 @WS 2 -PVP nanocapsule structure, take a little Fe 3 o 4 @WS 2 -PVP and Fe loaded with DOX 3...

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Abstract

The invention provides nanocapsules having a core-shell structure, the nanocapsules are composed of WS2 nanocapsules, the inner part of the WS2 nanocapsules is coated with the Fe3O4 nano particles, and the surface of the WS2 nanocapsules is synchronously modified with a polymer through covalent combination. The invention also provides a preparation method of the nanocapsules having the core-shellstructure, which comprises the following steps: the polymer, a sulfur source, a tungsten source and an iron source are dispersed in a solvent, and the materials are stirred and completely dissolved toobtain a mixed solution; the obtained solution is transferred to a stainless steel reaction vessel having a para-position polyphenyl inner liner for reacting for a certain time in a sealed mode, andthen centrifugation and washing are carried out to obtain the product which is the Fe3O4@WS2-polymer nanocapsules having good colloid stability with the inner part coated with the nano particles and the surface modified with the polymer. The invention also provides an application of the nanocapsules having the core-shell structure as a photo-thermal conversion material. The nanocapsules have highphoto-thermal conversion capability, and can be used in the fields of efficient cooperative diagnosis and treatment for tumor.

Description

technical field [0001] The invention belongs to the field of biological nanomaterials, in particular to a multifunctional and efficient magnetic Fe 3 o 4 @WS 2 - Polymer nanocapsules and their preparation and application. Background technique [0002] Cancer has become one of the important factors threatening human health. Traditional tumor treatment methods such as surgery, chemotherapy, and radiotherapy are affected by poor therapeutic efficacy and severe side effects, and the therapeutic effect is not satisfactory. In recent years, combined therapies that can synergistically kill tumor tissues or cancer cells have received attention. Integrating imaging and therapeutic functions within a single platform has become one of the approaches for specific and efficient tumor therapy. Imaging-guided tumor therapy brings new opportunities for high-precision anticancer. The paramagnetic iron-based nanomaterials that are taken up and enriched into tumor tissues or cells can be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K41/00A61K47/02A61K47/69A61K47/58A61K47/60A61K47/62A61K47/61A61K31/704A61P35/00B82Y5/00B82Y30/00B82Y40/00
Inventor 王世革吴陈瑶赵九龙胡飞周春华李佳玲邹多武
Owner UNIV OF SHANGHAI FOR SCI & TECH
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