18 results about "Intermittent dosing" patented technology

Disclosed are RAS(ON) multi-selective inhibitor compositions and methods of treating RAS protein-related diseases or disorders using an intermittent dosing regimen. RAS(ON) multi-selective inhibitors having tight binding to cyclophilin A (CypA) result in high exposure levels, prolonged tissue retention, and / or slow clearance rates, thereby increasing the risk of inhibition of wild-type RAS in normal tissues. Accordingly, provided herein are methods for the safe and effective dosing of low KD1 RAS(ON) multi-selective inhibitors using an intermittent dosing regimen. Also provided are methods of selecting or identifying such RAS(ON) multi-selective inhibitors suitable for intermittent administration.

Provided are intermittent administration methods for reducing toxicity in the treatment of conditions associated with increased 15-hydroxyprostaglandin dehydrogenase (15-PGDH) activity or expression levels in a subject with a 15-PGDH inhibitor. Further, provided herein are methods of treating a condition associated with increased 15-hydroxyprostaglandin dehydrogenase (15-PGDH) activity or expression level in a subject by administering a 15-PGDH inhibitor while maintaining the therapeutic effect of the 15-PGDH inhibitor when the plasma concentration of the 15-PGDH inhibitor in the subject drops below the EC50 of the 15-PGDH inhibitor.

Provided herein are methods of treating cancer using an improved intermittent dosing regimen for azenosertib or a pharmaceutically acceptable salt thereof to achieve a highly effective, safe, and well-tolerated dosing regimen for treating, among other things, many different types of cancer. In one aspect, the method of treating cancer comprises administering a daily dose (e.g., greater than about 350 mg) of azenosertib or a pharmaceutically acceptable salt thereof according to an improved intermittent dosing cycle, wherein the intermittent dosing cycle comprises one or more dosing weeks, each dosing week comprising about 2 to 7 consecutive dosing days and about 1 to 7 dosing-free days. In some embodiments, the intermittent dosing cycle is repeated, and the dosing weeks are separated by one, two, or more weeks of rest. In some aspects, azenosertib or a pharmaceutically acceptable salt thereof is administered as a combination therapy.

The present application relates to a kind of environmental sewage treatment intelligent dosing device and control system thereof, including processing box, the front surface of processing box is fixedly connected with control panel, the upper surface of processing box is fixedly connected with guide slide plate symmetrically;The present application is through the way of mechanical and system linkage to complete automatic rationality sewage dosing treatment, and through the cooperation between components, the effect of intermittent dosing is realized, and intermittent dosing process is accompanied by reorientation of medicament discharge, which helps to increase the discharge dispersion area of medicament, and the reasonable dosing amount management and automatic area stirring positioning adjustment are realized by data analysis, according to the medicament demand of different processing areas, reasonable and targeted dosing treatment is carried out, and the dosing amount of each processing area is monitored, so that the dosing condition of each processing area can be intuitively understood, and timely management adjustment is carried out, to ensure the accuracy of dosing.

The utility model relates to the technical field of wastewater treatment, and provides an automatic dosing device for oily sewage, which comprises a supporting seat, the universal wheels are arranged at four corners of the surface of one side of the supporting seat; the protective shell is arranged on the surface of the supporting seat, a limiting groove is formed in the surface of the protective shell, a hydraulic cylinder is arranged on the inner wall of the protective shell, an L-shaped connecting rod is arranged at the output end of the hydraulic cylinder, and the L-shaped connecting rod is embedded in the limiting groove in a sliding mode. According to the device, when the device moves to a designated place, the transparent barrel is filled with chemicals, the first gear drives the second gear meshed with the first gear to rotate through work of the driving motor, the connector on the surface of the conveying pipe rotates in the sealing gasket, and meanwhile sealing work is provided; and the medicament falls into the conveying pipe through gravity, so that the intermittent dosing work is completed, and the waste of medicament materials is reduced.

Disclosed herein are methods of treating glioblastoma in a subject comprising, among others, administration of sub-maximal tolerance doses and / or intermittent doses of phosphoinositide 3-kinase (PI3K) inhibitors, autophagy inhibitors and / or checkpoint inhibitors.

Disclosed are RAS(ON) multi-selective inhibitor compositions and methods of treating RAS protein-related diseases or disorders using an intermittent dosing regimen. RAS(ON) multi-selective inhibitors having tight binding to cyclophilin A (CypA) result in high exposure levels, prolonged tissue retention, and / or slow clearance rates, thereby increasing the risk of inhibition of wild-type RAS in normal tissues. Accordingly, provided herein are methods for the safe and effective dosing of low KD1 RAS(ON) multi-selective inhibitors using an intermittent dosing regimen. Also provided are methods of selecting or identifying such RAS(ON) multi-selective inhibitors suitable for intermittent administration.

The present application provides a method of administration that maximizes the therapeutic effect of adrenomedullin, and a drug containing adrenomedullin provided by the method of administration. The above problem is solved by providing a drug for treating a disease, which contains adrenomedullin or a derivative thereof having adrenomedullin activity, etc. as an effective ingredient, characterized in that the disease is a disease for which a therapeutic effect is expected to be obtained by administration of adrenomedullin or a derivative thereof having adrenomedullin activity, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, and the effective ingredient is administered intermittently.

Methods and compositions are disclosed for rapidly relieving symptoms in subjects with depressive, stressor and substance abuse conditions, e.g., major depression, treatment-resistant depression, post-partum depression, bipolar depression, post-traumatic stress disorder, substance use disorders, negative and cognitive symptoms of schizophrenia, as well as for slowing progression of mild cognitive impairment and dementia, using an intermittent dosing regimen of memantine or amantadine or a structural analogue or pharmaceutically acceptable salt of memantine or amantadine (optionally no more frequently than every 2 days) at a dose sufficient to activate Set A brain structures, in combination with a second drug at a dose which activates Set B brain structures but which does not appreciably evoke brain activity linked to hallucinogenic and other psychotomimetic perceptions. In some instances the second drug is either 1) a low dose psilocybin or low dose of other psychedelic and stimulant molecules capable of activating Set B of brain structures which is administered at a dose low enough such that it does not appreciably evoke brain activity linked to hallucinogenic and other psychotomimetic perceptions, or is 2) mianserin (S isomer, R isomer, or a racemate comprising both isomers or structural analog or pharmaceutically acceptable salt thereof) or another standard of care antidepressant capable of activating Set B brain structures, or 3) lumateperone or another antipsychotic capable of activating Set B brain structures.

The application relates to the technical field of wastewater treatment, in particular to a multistage treatment device for industrial heavy metal wastewater, which comprises an integrated wastewater treatment tank, the integrated wastewater treatment tank is composed of a sedimentation tank, a reaction tank and a residue filter tank, a dosing box is fixedly installed at the upper end of the reaction tank, and a dosing mechanism is arranged on the inner side of the dosing box. By combining the dosing mechanism with the mixing mechanism, intermittent dosing of the medicament during the reaction of the industrial wastewater is realized, the dynamic mixing of the mixed solution in the reaction cavity is ensured, and the heavy metal precipitation reaction efficiency is improved; by combining the aeration assembly with the spherical frame, uniform aeration is realized, and the overall structural support strength of the spherical frame is ensured; by arranging the clamp reinforcing assembly, the spherical frame is clamped, the overall structure is reinforced, the clamp reinforcing assembly is combined with the uniform aeration assembly, the bidirectional locking effect of the two is achieved, the mixing and stirring effect of the wastewater is achieved, and one object has multiple uses.

The utility model relates to the technical field of fracturing flow-back liquid recycling and discloses an efficient fracturing flow-back liquid recycling device which comprises a mixing box, a chemical feeding pipe is fixedly connected to the upper end face of the mixing box in a penetrating mode, a storage box is fixedly connected to the upper end of the chemical feeding pipe, a partition plate is fixedly connected to the interior of the chemical feeding pipe, and leakage holes are formed in the partition plate. Baffles are symmetrically attached to the lower end face of the partition plate, and the baffles are slidably connected to the chemical feeding pipe in a penetrating mode, so that chemical agents in the storage box can be intermittently fed into the mixing box through the chemical feeding pipe in the rotating process of the stirring shaft, uniform distribution of the chemical agents in the mixing box is facilitated, and the mode is different from a continuous chemical feeding mode; by means of the intermittent dosing mode, the dosing speed and quantity of the medicament can be better controlled, the situation that the local concentration of the medicament is too high or too low can be avoided, the mixing effect and the utilization rate of the medicament are improved, and unnecessary waste can be avoided and energy and cost can be saved by accurately controlling the dosing quantity and the time interval of the medicament.

The present application belongs to the technical field of mine water treatment, in particular to a combined water purification equipment for mine water treatment, comprising a treatment bucket, a rotating shaft is rotatably connected to the bottom center of the inner cavity of the treatment bucket, a plurality of stirring blades are fixedly connected to the rotating shaft in the circumferential direction, a filter box is fixedly connected to one side of the top of the side wall of the treatment bucket, a filter screen is fixedly connected to one side of the inner wall of the filter box, and one end of the filter box is communicated with the inner cavity of the treatment bucket through a connecting pipe. The present application utilizes a volume-adjustable intermittent dosing assembly, and the amount of medicament added to the water each time is exactly the amount that fills one chamber of the medicament storage chamber, thereby realizing the constant-volume metering of solid medicament. Since the amount of medicament added each time is uniquely determined by the volume of the medicament storage chamber and is independent of the flow rate fluctuation of the medicament in the pipeline, the problem of inconsistent dosing caused by the length of time that the valve is open being affected by the flow rate is completely avoided, and the accuracy of the dosing amount is significantly improved.

This radioactive antitumor agent comprises a radioactive dithiosemicarbazone-copper complex as an active ingredient, and is characterized by being used in such a way that the radioactive dithiosemicarbazone-copper complex is administered multiple times to an organism requiring tumor treatment, at a radioactive dose that avoids dose-limiting toxicity, as determined on the basis of hematological parameters. The multiple administration preferably consists of intermittent administration at time intervals allowing the hematological parameters to return to a normal range.

The invention discloses a quantitative design method for gas well intermittent dosing parameters, and relates to the technical field of gas well foam drainage gas recovery. According to the method, gas well basic parameters and produced liquid physical property parameters are collected, on the basis of a Lie Fujian critical liquid carrying model and a foam liquid carrying lower limit equation, a quantitative calculation formula of the critical liquid accumulation amount and the dosing period is deduced, the single-time dosing amount is calculated in combination with the standard dosing concentration, and quantitative design of intermittent dosing parameters is achieved. As only aiming at the liquid phase which cannot be taken away by the gas-phase liquid-carrying flow velocity, a quantitative calculation basis is provided for on-site dosing parameter optimization, and meanwhile, the dosage of the medicament is reasonably reduced.

Provided herein are compositions and dosing regimens of a calcineurin inhibitor and a cytochrome p450 inhibitor.

The invention relates to the technical field of ecological environment protection, in particular to an ecological environment-friendly sludge treatment device and method.The ecological environment-friendly sludge treatment device comprises a mixing mechanism and a stirring component, the stirring component comprises a shell, a support and a filter screen, the bottom of the support is fixedly connected with the top of the shell, and the surface of the filter screen is fixedly connected with the interior of the shell; sludge can be stirred and treated through the stirring part, the fluidity can be improved, sludge can be mixed through closing of the blocking part, sludge can be discharged when the blocking part is opened, automatic intermittent chemical feeding can be achieved through the chemical feeding part under the use of the stirring part, and the uniform mixing performance of sludge and chemicals is improved; the operation of the stirring component can also automatically drive the compression component to accelerate the filtering effect on the sludge, the compression component can automatically drive the air injection component and the air suction component in the using process, external air is injected into the shell, peculiar smell gas of the sludge is pumped out and filtered, and large-particle impurities can be discharged through the discharging component.

Provided herein are compositions and dosing regimens of a calcineurin inhibitor and a cytochrome p450 inhibitor.

Provided herein is, among other things, is a method of treating cancer using an improved intermittent dosing regimen for Azenosertib, or a pharmaceutically acceptable salt thereof, administration to achieve a highly efficacious, safe and tolerable dosing regimen to treat many different types of cancers. In one aspect, the method of treating cancer comprises administering a daily dose of Azenosertib, or a pharmaceutically acceptable salt thereof, (e.g., greater than about 350 mg) in accordance with an improved intermittent dosing cycle, wherein the intermittent dosing cycle comprises one or more dosing weeks with each dosing week comprising between about 2-7 consecutive dosing days and between about 1-7 days without dosing. In some embodiments, the intermittent dosing cycle is repeated wherein the dosing weeks are separated by a break of one, two or more weeks. In some aspects, Azenosertib, or a pharmaceutically acceptable salt thereof, is administered as a combination therapy.