45 results about "Contact activation" patented technology

The present invention provides compounds of Formula (I):or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4, R4, R5, R13, R14, R15 and R16 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and / or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and / or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and / or inflammatory disorders using the same.

The present invention provides a method for treating a thrombotic or an inflammatory disorder administering to a patient in need thereof a therapeutically effective amount of at least one compound of Formula (I) or Formula (V):or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, R4, R6, R11, X1, X2, and X3 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and / or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and / or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also provides compounds within the scope of Formula I and relates to pharmaceutical compositions comprising these compounds.

Provided is a detector for fishing in order to detect the depth of water, the temperature of water, the distribution of fishes including fishes' migration and / or the length of fishes. The detector includes: a sensor transmitting an ultrasonic signal into the water in a fishing site and receiving a reflective ultrasonic signal reflected from an underwater object; a control unit analyzing / determining the waveform of the reflective ultrasonic signal measured in the sensor to then be indicated on an indication unit including a light-emission indicator, a numeric indicator, and a water depth / temperature indicator; a switching unit having an elevating rod whose lower end contacts an activation switch to turn on / off electric power supplied from a power source and in the upper end of which a fishing line engagement hole is formed in which a fishing line is connected with the fishing line engagement hole and the elevating rod is exposed to the outside to then be elastically pressed to be opened and closed according to the pressure of the elevating rod; and a main body on the upper surface of which a light-emission indicator, a numeric indicator, and a water depth / temperature indicator are formed, and in which the sensor, the control unit, and the switching unit are embedded in a sealed manner with a predetermined structure. The detector further includes a transmitter transmitting a signal representing the analyzed / determined result in the form of a predetermined waveform wirelessly. The wireless signal transmitted from the transmitter in the fishing detector is received and displayed using a predetermined program via a predetermined receiver having a display such as a personal portable communications terminal like a mobile telephone.

The present invention provides compounds of Formula (I):or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, R3 and R11 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and / or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and / or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and / or inflammatory disorders using the same.

A fabric product with a low powered activation device and a conductive arrangement, which includes a body having an outer covering which is soft and flexible to providing an outer skin surface and an inner skin surface, and defines a body receiving cavity. The low powered activation device is an electronic unit received inside the body receiving cavity which comprises a casing, a power source, an activation circuit, and an operator which is activated through the activation circuit. The conductive arrangement electrically connects between the electronic unit and the outer skin surface, which includes one or more conductive threads affixed on the inner skin surface, each having one end portion defining an activation control which penetrates through the inner skin surface to the outer skin surface, thereby when the activation control is contacted by a user, the activation circuit is activated to activate the operator of the electronic unit.

A shutter operating system is provided that depends on electromagnetic energy to operate shutter blades. A permanent magnet and solenoid system operate the shutter blades. Movement of the magnet causes the shutter blades to move between an open and a closed position over a lens. The permanent magnet can be moved between a pair of spaced coils by selectively energizing first one coil then the other. The magnet can be attached directly to a shutter blade or in the case of a rotary shutter, the magnet can be attached to a drive ring that in turn is mechanically coupled to the shutter blades.