44 results about "Contact activation" patented technology

The present invention provides compounds of Formula (I):

or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R³, and ring B are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

The present invention provides compounds of Formula (I):

or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, R³ and R¹¹ are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

A contact activated vacuum assisted suction cup assembly comprising: 1) a cylindrical bellowed or corrugated cup defining a plurality of interconnected bellows or corrugations of alternating, coaxial large and small diameter areas, hereinafter “bellows”, and having; A) an open contact end; and B) a valve end including a valve seat; 2) a valve stem having first and second extremities; 3) a valve plate intermediate the open contact end and the valve end in one of the large diameter areas attached to the first extremity; and 4) a valve stop attached to the valve stem at the second extremity that can engage the valve seat in the closed position. A picking device comprising a vacuum plenum having a plurality of the previously described contact activated vacuum assisted suction cup assemblies mounted therein in plenum apertures that engage a peripheral flange about the valve end is also described.

The invention relates to a thermal regeneration furnace for waste powdered activated carbon, and belongs to the technical field of chemical industry. The thermal regeneration furnace is used for the thermal regeneration (100 to 850 DEG C) of waste powdered activated carbon obtained by refining and decolorizing medicines and fine chemicals. The thermal regeneration furnace is formed by serially connecting a plurality of dry distillation trays and activation trays, which are provided with rotary stirrers, wherein the dry distillation trays are vertically arranged on the activation trays; and waste powdered carbon is continuously and quantificationally added, indirect heating is adopted for dry distillation, the activation is that high-temperature activation gas is generated by using water gas generated in the thermal regeneration process and an oxygen-enriched combustion improver, and over-heated water vapor is doped and taken as activation gas for direct contact activation, organic matter in the waste carbon can be completely decomposed and removed through dry distillation and activation in an innocent manner, the waste powdered carbon can be generated, and the original adsorption performance and the original adsorption indexes are restored. The thermal regeneration of the waste powdered carbon is a most effective technical means for realizing the cyclic utilization of industrial waste powdered carbon, environmental pollution caused by inappropriately disposing the waste powdered carbon which is taken as garbage, and also ensures that powdered carbon resources are recycled; and the thermal regeneration also has a relatively high economic benefit.

An activation unit for explosive masses or explosive bodies includes an ejector tube and high-performance heating elements mounted around the ejector tube, each made of at least one heating wire supplied with electrical power by a control unit. Each heating wire is enclosed in a casing and embedded in a material minimizing heat loss. When the explosive body is passed through the activation unit, the jacket surface of the explosive body contacts the individual elements of the activation unit in a direct or non-contact manner. Thermal energy is transferred to the explosive body by means of the heating wires, and the body ignites at the contact points. A further activation unit includes heating elements in the ejector tube, at least partially fed longitudinally through the ejector tube, made of heating wire clad with CrNi steel and contact plates soldered thereto.

A contact activated incision device, comprises a housing defining a cavity, and a longitudinal axis extends between a proximal end and a distal end of the housing. A slider is slidable with respect to the housing along the longitudinal axis and at least partially positioned outside of the housing. A roller is mounted on the housing and rotatable about an axis perpendicular to the longitudinal axis. A blade assembly is mounted on the roller and has a blade, wherein the blade is movable from a retracted position to an extended position and to a final position, at the retracted position the blade is positioned in the cavity, at the extended position the blade extends at least partially beyond the proximal end of the housing, and at the final position the blade is positioned in the cavity.

The present invention provides compounds of Formula (I) or (II):

or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L₁, R³, R⁴, R^8a, R¹¹ and M are as defined herein. The compounds of Formula (I) or (II) are selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1) gene, the Factor XII (Hageman Factor (F12) gene, or theKininogen 1 (KNG1) gene, and methods of using such RNAi agents to inhibit expression of a KLKB1 gene, an F12 gene, and/or a KNG1 gene, and methods of treating subjects having an hereditary angioedema(HAE) and/or a contact activation pathway-associated disorder.

The invention relates to a preparation method and application of a time temperature indicator based on lipase reaction diffusion. The preparation method comprises the following steps of: preparing an upper cover containing a gel reaction substrate and a bottom board containing a gel enzyme substrate; before activation, separating the upper cover containing the gel reaction substrate from the bottom board containing the gel enzyme substrate and refrigerating at the temperature of 4 DEG C; during use, pressing the upper cover containing the gel reaction substrate on the bottom board containing the gel enzyme substrate, so that substrate gel of the gel reaction substrate is contacted with the gel enzyme substrate for activation; performing an enzymatic reaction after the substrate gel is contacted with the gel enzyme substrate to form a yellow belt; judging and determining the accumulation effect of the yellow belt on time and temperatures according to the diffusion length of the yellow belt; and performing the matching of activation energy with food to be predicted according to the relation between the activation energy of an established time temperature indicator (TTI) and influence factors, so that the quality condition of the food during production, storage and transportation and sale can be monitored conveniently and reliably.

The present invention provides compounds of Formula (I):

or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, L₁, R³, and R¹¹ are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

A thickness measuring device of a laminating machine includes a mount, a stepper motor, a screw rod, a first contact-activated element, a second contact-activated element, and a microcontroller unit. The stepper motor is coupled to the mount. The screw rod is interlocked with the stepper motor. The first contact-activated element is provided at a position corresponding to and some distance below the screw rod. The second contact-activated element is provided at a position corresponding to and some distance above the screw rod. The microcontroller unit is electrically connected to the stepper motor, the first contact-activated element, and the second contact-activated element so as to provide initialization setting and exercise judgment and control after receiving a thickness measurement. Thus, the thickness of an object to be detected can be conveniently measured.

For operation of contact-less identification media in a system with contact applications for contact cards, an initialized converter module is connected in series as a read/write station. This converter module, on the one hand, executes a contact-less communication with initialized contact-less identification media and, on the other hand, a contact communication at a contact card interface to a host computer or to an application computer for the communication with a contact application of the system and the converter module translates the contact-less communication with respect to communication rules and information into a contact communication with contact information and vice versa and the initialization of the converter module is defined in a hierarchic authorization system. This makes possible a particularly simple and efficient introduction of contact-less identification media into existing contact card systems and—installations.

A fabric product with a low powered activation device and a conductive arrangement, which includes a body having an outer covering which is soft and flexible to providing an outer skin surface and an inner skin surface, and defines a body receiving cavity. The low powered activation device is an electronic unit received inside the body receiving cavity which comprises a casing, a power source, an activation circuit, and an operator which is activated through the activation circuit. The conductive arrangement electrically connects between the electronic unit and the outer skin surface, which includes one or more conductive threads affixed on the inner skin surface, each having one end portion defining an activation control which penetrates through the inner skin surface to the outer skin surface, thereby when the activation control is contacted by a user, the activation circuit is activated to activate the operator of the electronic unit.

The present invention relates to a contact activation system inhibitor, preferably a C1INH, for use in the treatment and/or prevention of remote ischemia-reperfusion injury (IRI), comprising administering the contact activation system inhibitory to an individual.

The invention belongs to the technical field of medical apparatuses and instruments and particularly relates to a medical biodegradable compound hemostatic sponge having high water absorption and a preparation method thereof. The hemostatic material for the medical biodegradable compound hemostatic sponge is made from a copolymer and is stable in performance. Squid ink polysaccharide provides powerful and comprehensive hemostatic functions, the shortcoming that chitosan cannot activate a blood coagulation factor VII is overcome, and dodecyl chitosan can rapidly stop arterial bleeding. Oxidized microcrystalline cellulose is introduced into collagen liquid and has good hygroscopicity and stability, blood coagulation can be promoted through contact activation, and the hemostatic performance is excellent. Safe and non-toxic crosslinking is adopted, the hemostatic sponge is orderly in net-shaped structure, pore distribution is uniform, the organization is loose and soft, and the toughness is good.

The invention discloses an anti-overflow paint brush. The anti-overflow paint brush comprises a horizontally arranged U-shaped work mounting plate, wherein a work mounting cylinder is horizontally androtatably installed at the middle position of the upper half section of the U-shaped work mounting plate. A rotating guiding structure is arranged at the position, on the left side of the work mounting cylinder, in the U-shaped work mounting plate in a matched mode, and a power transmission structure is vertically arranged at the position, on the right side of the work mounting cylinder, in the U-shaped work mounting plate in an inlaid mode. A guiding operating rod is disposed vertically at the middle position of the lower part of the U-shaped work mounting plate, and a supporting mounting plate is horizontally disposed at the upper end of the guiding operating rod. Rotating mounting columns are separately disposed at the left and right ends of the supporting mounting plate through rotating shafts in an upward rotating mode, and the upper ends of the rotating mounting columns are separately and symmetrically fixed to the lower end of the U-shaped work mounting plate through rotating shafts. The anti-overflow paint brush has the advantages of compact structure design, high guiding efficiency, effective prevention of paint splashing by contact activation, continuous painting operation, high efficiency and the like.

The present invention relates to methods of use of RNAi agents, e.g., double stranded RNAi agents, targeting a Factor XII (Hageman Factor (F12) gene, for treating subjects having a contact activation pathway-associated disease, such as a thrombophilia or hereditary angioedema (HAE), methods for preventing at least one symptom in a subject having a contact activation pathway-associated disease, such as a thrombus formation or an angioedema attack, and RNAi agents targeting an F12 gene, for use in the methods of the invention.

The present invention relates to a catalytic conversion method for directly processing a high chlorine raw material. The method comprises that a pre-heated high chlorine raw material and a first catalytic conversion catalyst are subjected to a first contact reaction to make the chlorine-containing compound in the high chlorine raw material be adsorbed on the first catalytic conversion catalyst and decompose less than or equal to 30% by weight of the chlorine-containing compound to obtain a first contacting product; and the first contacting product and a second catalytic conversion catalyst are subjected to a second contact reaction to remove the chlorine-containing compound, wherein the reaction temperature of the second contact reaction is higher than the reaction temperature of the first contact reaction. With the method of the present invention, the high chlorine raw material can be directly processed while the high dechlorination rate can be obtained, the high chlorine raw material conversion rate can be improved, the product selectivity can be improved, and the dry gas yield and the coke yield can be reduced.

Provided is a folder binding device comprising a binding assembly including a table inclined toward rear, two uprights at both rear corners of the table, a platen moveably provided across the uprights, a central rod extended upward from the platen, and two parallel guide posts extended upward from positions proximate both ends of the platen; and a detachable heater including a front heating member. Placing one or more folders on the table with a joint of each folder facing the platen wherein each folder has orderly sheets put together by adhesive, lowering the platen by pushing down the rod to press the joint of each folder and cause each joint to be in contact with the heating member, and activating the heating member will melt the adhesive in each folder to bind the sheets thereof after cooling.