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Medical biodegradable compound hemostatic sponge having high water absorption and preparation method thereof

A biodegradable and hemostatic sponge technology, applied in the field of medical devices, can solve the problems of unsatisfactory biocompatibility, inability to absorb exudate in time, poor biodegradability, etc., and achieve good hygroscopicity and stability, and a mesh structure Neat and stable performance

Inactive Publication Date: 2017-11-03
TAICANG CUSTOM NEW MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic sponge has the characteristics of little damage to the tissue, easy operation, and rapid hemostasis, but the biocompatibility of the hemostatic sponge in the prior art is still not ideal, and the water absorption performance is poor, which usually leads to the loss of the liquid absorption performance, and the exudate cannot be absorbed. Timely absorption, poor hemostatic effect, poor biodegradability and potential carcinogenic risk

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A biodegradable superabsorbent medical composite hemostatic sponge described in this example comprises the following components by weight: 2 parts of oxidized microcrystalline cellulose, 8 parts of swim bladder collagen stock solution, 20 parts of dodecyl chitosan 5 parts of squid ink polysaccharide, 1 part of polyethylene glycol, 5 parts of ε-caprolactone, 1 part of strontium gluconate, 1 part of iron dextran, 1 part of panax notoginseng extract, 0.5 part of eucalyptol, cross-linking agent 1 part, Tween-60 1 part, ethanol 25 parts, deionized water 65 parts.

[0024] The weight average molecular weight Mw of polyethylene glycol described in this embodiment is 1000-20000.

[0025] The crosslinking agent described in this embodiment is a mixture of sodium diacetate, sodium trimetaphosphate, citric acid and calcium chloride in a weight ratio of 0.5:2.5:1:0.5.

[0026] The method for extracting the Radix Notoginseng extract described in this embodiment is to dry and pulver...

Embodiment 2

[0037] A biodegradable superabsorbent medical composite hemostatic sponge described in this example comprises the following components by weight: 8 parts of oxidized microcrystalline cellulose, 16 parts of squid skin collagen stock solution, dodecyl chitosan 30 parts, 9 parts of squid ink polysaccharide, 3 parts of polyethylene glycol, 8 parts of ε-caprolactone, 3 parts of strontium gluconate, 2 parts of iron dextran, 5 parts of panax notoginseng extract, 1.5 parts of eucalyptol, cross-linked 3 parts of agent, 3 parts of Tween-60, 40 parts of ethanol, 85 parts of deionized water.

[0038] The weight average molecular weight Mw of polyethylene glycol described in this embodiment is 1000-20000.

[0039] The crosslinking agent described in this embodiment is a mixture of sodium diacetate, sodium trimetaphosphate, citric acid and calcium chloride in a weight ratio of 0.5:2.5:1:0.5.

[0040] The method for extracting the Radix Notoginseng extract described in this embodiment is to...

Embodiment 3

[0051] A biodegradable superabsorbent medical composite hemostatic sponge described in this example comprises the following components by weight: 5 parts of oxidized microcrystalline cellulose, 12 parts of swim bladder collagen stock solution, 25 parts of dodecyl chitosan 7 parts of squid ink polysaccharide, 2 parts of polyethylene glycol, 7 parts of ε-caprolactone, 2 parts of strontium gluconate, 1 part of iron dextran, 3 parts of panax notoginseng extract, 1 part of eucalyptol, cross-linking agent 2 parts, Tween-60 2 parts, ethanol 33 parts, deionized water 70 parts.

[0052] The weight average molecular weight Mw of polyethylene glycol described in this embodiment is 1000-20000.

[0053] The crosslinking agent described in this embodiment is a mixture of sodium diacetate, sodium trimetaphosphate, citric acid and calcium chloride in a weight ratio of 0.5:2.5:1:0.5.

[0054] The method for extracting the Radix Notoginseng extract described in this embodiment is to dry and pu...

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PUM

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Abstract

The invention belongs to the technical field of medical apparatuses and instruments and particularly relates to a medical biodegradable compound hemostatic sponge having high water absorption and a preparation method thereof. The hemostatic material for the medical biodegradable compound hemostatic sponge is made from a copolymer and is stable in performance. Squid ink polysaccharide provides powerful and comprehensive hemostatic functions, the shortcoming that chitosan cannot activate a blood coagulation factor VII is overcome, and dodecyl chitosan can rapidly stop arterial bleeding. Oxidized microcrystalline cellulose is introduced into collagen liquid and has good hygroscopicity and stability, blood coagulation can be promoted through contact activation, and the hemostatic performance is excellent. Safe and non-toxic crosslinking is adopted, the hemostatic sponge is orderly in net-shaped structure, pore distribution is uniform, the organization is loose and soft, and the toughness is good.

Description

technical field [0001] The invention belongs to the technical field of medical devices, in particular to a biodegradable superabsorbent medical composite hemostatic sponge and a preparation method thereof. Background technique [0002] As a common medical consumable, hemostatic sponge has the functions of absorbing exudate, quickly stopping bleeding, preventing adhesion, and promoting wound healing. The hemostatic sponge is generally used clinically for capillary exudative hemostasis during visceral surgery. The clinical application of hemostatic sponge includes general surgery, cardiovascular surgery, plastic surgery, urology, orthopedics, dermatology, burns, gynecology, stomatology, ophthalmology and other departments. The hemostatic sponge has the characteristics of little damage to the tissue, easy operation, and rapid hemostasis, but the biocompatibility of the hemostatic sponge in the prior art is still not ideal, and the water absorption performance is poor, which us...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/10A61L24/00A61L24/04C08B37/08C08G63/664C08J9/28
Inventor 李瑞清
Owner TAICANG CUSTOM NEW MATERIALS CO LTD
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