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Sepia polysaccharide/chitosan hemostatic sponge and preparation method and application thereof

A technology of hemostatic sponge and chitosan, which can be used in applications, pharmaceutical formulations, lighting and heating equipment, etc., and can solve problems such as poor biocompatibility, irritating side effects, and insufficient hemostatic effect

Active Publication Date: 2017-02-22
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the poor biocompatibility, long hemostatic time, poor effect of absorbing bleeding, weak wound repair ability, insufficient hemostatic effect, strong side effects or irritation in the prior art, and the preparation of Longer time for the above-mentioned defects, a squid ink polysaccharide / chitosan hemostatic sponge is provided

Method used

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  • Sepia polysaccharide/chitosan hemostatic sponge and preparation method and application thereof
  • Sepia polysaccharide/chitosan hemostatic sponge and preparation method and application thereof
  • Sepia polysaccharide/chitosan hemostatic sponge and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Dissolve squid ink polysaccharide in water to make a certain concentration of squid ink polysaccharide solution (A liquid); dissolve chitosan in 1% acetic acid solution to make a certain mass concentration of chitosan solution (B liquid); Take a certain amount of liquid B, put it in a 50ml beaker, slowly add a certain amount of liquid A, and stir evenly; take another certain amount of calcium chloride solution and add it to the solution in the above beaker, accelerate and fully stir to make it evenly mixed, and pour the mixture Put it into a petri dish with a diameter of 6cm, and observe the gelation state. After the gel is completely formed, the petri dish is frozen at -20°C for 12 hours, and then freeze-dried for 16-20 hours to make a porous spongy solid, that is, squid ink. Polysaccharide-chitosan hemostatic sponge.

[0037] (1) Effect of molecular weight of chitosan on the preparation process of composite hemostatic sponge

[0038]Investigate chitosan molecular wei...

Embodiment 2

[0057] Embodiment 2 star point design-response surface method experimental design

[0058] Taking the comprehensive score of appearance quality and water absorption multiple of the hemostatic sponge as the investigation index, the three factors of squid ink polysaccharide concentration, chitosan mass concentration and calcium chloride mass concentration were investigated. According to the principle of star point design-response surface method, a 3-factor and 5-level experimental design is carried out. The factors and levels are shown in Table 6.

[0059]

[0060] 20 prescription combinations were generated by Design-Expert.V8.0.6 software, and the experimental results are shown in Table 7.

[0061]

[0062] to Y 1 and Y 2 As the dependent variable, use Design-Expert.V8.0.6 software to perform multiple linear regression, binomial, and trinomial fitting on the independent variables with each dependent variable, and use the multiple correlation coefficient (R²) and confid...

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PUM

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Abstract

The invention provides a preparation method of sepia polysaccharide / chitosan hemostatic sponge. The preparation method includes slowly adding 0.4-0.8mg / mL of sepia polysaccharide solution into 1.5-3.5% of chitosan solution, after mixing, adding 2-6% of calcium chloride solution, freezing gel after being formed, and then freezing-drying. With the star point design effect surface method to preferably prepare the hemostatic sponge, the sepia polysaccharide / chitosan hemostatic sponge good in quality is obtained by analyzing the effect surface figure and comparing the sponge products prepared by the optimal method given by the software with the predictive indexes. In the invention, time for the preparation method of the whole hemostatic sponge is shorter than that of most of the existing studies, which not only reduces the energy consumption but also improves the production efficiency. The hemostatic sponge has good biocompatibility, short stopping time, good in bleeding absorption effect, high in trauma repair ability, comprehensive in hemostatic effect, and weak in toxic and side effects or irritation. In addition, the method has a wide range of applications.

Description

technical field [0001] The invention relates to the technical field of hemostatic sponge preparation, more specifically, to a squid ink polysaccharide / chitosan hemostatic sponge and its preparation method and application. Background technique [0002] As a new type of hemostatic material, biomedical materials are considered to be one of the most effective materials for local trauma hemostasis. They have the advantages of absorbability, high efficiency, economy and non-toxicity. The higher it is, the more important its hemostatic effect becomes. It mainly uses the characteristics and advantages of its own materials to absorb blood, aggregate platelets, block blood vessels, promote thrombin production or activate coagulation factors, so as to achieve hemostasis. [0003] At present, relatively mature biological hemostatic materials mainly include alginate sponge, chitosan sponge, collagen sponge and some composite sponges. Due to the different components, these materials als...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08
CPCA61L24/043A61L2300/232A61L2300/418A61L2400/04C08L5/08C08L5/00A61L24/0005A61L24/0036A61L24/02C08B37/003C08K2003/162F26B5/06A61L24/08
Inventor 黄娜李思东董建宁孔松芝洪鹏志陈法锦李高荣
Owner GUANGDONG OCEAN UNIVERSITY
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