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Preparation method of gold nanocluster emitting red fluorescence and detection method for penicillamine

A gold nanocluster and detection method technology, applied in the field of gold nanocluster preparation and application, can solve problems such as side effects, and achieve the effects of mild preparation reaction conditions, good water solubility, and excellent photostability

Inactive Publication Date: 2018-06-12
ANHUI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although penicillamine can treat many diseases, it can also cause some side effects
20-30% of patients taking penicillamine will have side effects, such as bone marrow suppression, taste disturbance, anorexia, vomiting and diarrhea, etc.
By adjusting the function on the surface of metal nanomaterials, nanomaterials with stable red fluorescence can be obtained, and a new type of fluorescent chemical sensing principle and method can be used to establish a technology for rapid and sensitive detection of penicillamine, which has not yet been reported.

Method used

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  • Preparation method of gold nanocluster emitting red fluorescence and detection method for penicillamine
  • Preparation method of gold nanocluster emitting red fluorescence and detection method for penicillamine
  • Preparation method of gold nanocluster emitting red fluorescence and detection method for penicillamine

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Experimental program
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Effect test

Embodiment 1

[0028] 1. Preparation of gold clusters modified with 11-mercaptoundecanoic acid

[0029] Soak all glassware and magnetic stir bars in aqua regia for 30 minutes before preparation, and rinse with ultrapure water several times before use. First, add 0.0545g of 11-mercaptoundecanoic acid into a round bottom flask with 15ml of ultrapure water, then add 0.75ml of 1mol / L sodium hydroxide, dissolve it completely under ultrasonic conditions, and then stir for ten minutes. Then add 6.25ml concentration of 10mmol / L chloroauric acid solution into the flask, stir at room temperature for five hours, observe the change of the fluorescence intensity of the reaction solution at any time. The reaction was stopped after five hours, and the reaction mixture was added to a 1000 molecular weight dialysis bag and dialyzed in ultrapure water for 12 hours, during which the water was changed every 6 hours. Take out the dialyzed clear solution, add it to a centrifuge tube, centrifuge at 12,000rpm for ...

Embodiment 2

[0037] 1. Preparation of gold clusters modified with 11-mercaptoundecanoic acid

[0038] Soak all glassware and magnetic stir bars in aqua regia for 30 minutes before preparation, and rinse with ultrapure water several times before use. First, 0.109g of 11-mercaptoundecanoic acid was added into a round-bottomed flask with 15ml of ultrapure water, then 0.5ml of 1mol / L sodium hydroxide was added, and it was completely dissolved under ultrasonic conditions, followed by stirring for 20 minutes. Then add 6.25ml concentration of 10mmol / L chloroauric acid solution into the flask, stir at room temperature for 12 hours, observe the change of the fluorescence intensity of the reaction solution at any time. After 12 hours, the reaction was stopped, and the reaction mixture was added into a dialysis bag with a molecular weight of 1000 and dialyzed in ultrapure water for 12 hours, during which the water was changed every 4 hours. The dialyzed clear solution was taken out, put into a centr...

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Abstract

The invention discloses a preparation method of a gold nanocluster emitting red fluorescence and a detection method for penicillamine and also discloses a sensitive detection method for penicillaminein actual water samples and urine. The method for preparing the gold cluster is simple, the reaction condition is mild, the obtained gold cluster has good light stability and water solubility and highquantum yield. The gold cluster is combined with copper ions to build a fluorescence-quenching sensing system which can be used for fluorescence-enhanced detection of the penicillamine; the detectionmethod for the penicillamine is low in detection limit, good in selectivity and strong in interference resistance and can be used for detecting the penicillamine in the complex actual samples; when the samples contain the penicillamine, the existence of the penicillamine in the actual samples can be judged only by using a simple handheld ultraviolet lamp to observe the change of the color of thesample solution by the naked eyes.

Description

Technical field: [0001] The invention belongs to the technical field of preparation and application of gold nanoclusters, in particular to a preparation method of red fluorescent gold nanoclusters and a detection method for penicillamine, in particular to the use of the material for penicillamine in actual water samples and urine Quantitative analysis of mycamine concentration. Background technique: [0002] Penicillamine is a hydrolysis metabolite of penicillin, which has important application value in pharmacy. Penicillamine can be used to treat fibrotic lung disease, heavy metal poisoning, and progressive systemic sclerosis. As an immunosuppressant, it is often used to treat rheumatoid arthritis by reducing the number of T-lymphocytes. It can also be used in the treatment of Wilson's disease to regulate the disordered copper metabolism in the body by coordinating with the accumulated copper in the body. Although penicillamine can treat many diseases, it can also cause ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64B22F9/24B82Y40/00
CPCG01N21/643B22F9/24B82Y40/00G01N2021/6432
Inventor 张奎何利芳
Owner ANHUI UNIVERSITY OF TECHNOLOGY
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