Preparation method of gold nanocluster emitting red fluorescence and detection method for penicillamine

A gold nanocluster and detection method technology, applied in the field of gold nanocluster preparation and application, can solve problems such as side effects, and achieve the effects of mild preparation reaction conditions, good water solubility, and excellent photostability
CN108152259AInactive Publication Date: 2018-06-12ANHUI UNIVERSITY OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ANHUI UNIVERSITY OF TECHNOLOGY
Publication Date
2018-06-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of a gold nanocluster emitting red fluorescence and a detection method for penicillamine and also discloses a sensitive detection method for penicillaminein actual water samples and urine. The method for preparing the gold cluster is simple, the reaction condition is mild, the obtained gold cluster has good light stability and water solubility and highquantum yield. The gold cluster is combined with copper ions to build a fluorescence-quenching sensing system which can be used for fluorescence-enhanced detection of the penicillamine; the detectionmethod for the penicillamine is low in detection limit, good in selectivity and strong in interference resistance and can be used for detecting the penicillamine in the complex actual samples; when the samples contain the penicillamine, the existence of the penicillamine in the actual samples can be judged only by using a simple handheld ultraviolet lamp to observe the change of the color of thesample solution by the naked eyes.
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Description

Technical field:

[0001] The invention belongs to the technical field of preparation and application of gold nanoclusters, in particular to a preparation method of red fluorescent gold nanoclusters and a detection method for penicillamine, in particular to the use of the material for penicillamine in actual water samples and urine Quantitative analysis of mycamine concentration. Background technique:

[0002] Penicillamine is a hydrolysis metabolite of penicillin, which has important application value in pharmacy. Penicillamine can be used to treat fibrotic lung disease, heavy metal poisoning, and progressive systemic sclerosis. As an immunosuppressant, it is often used to treat rheumatoid arthritis by reducing the number of T-lymphocytes. It can also be used in the treatment of Wilson's disease to regulate the disordered copper metabolism in the body by coordinating with the accumulated copper in the body. Although penicillamine can treat many diseases, it can also cause ...

Claims

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