84 results about "Gold cluster" patented technology

A process and catalyst for the hydro-oxidation of an olefin having three or more carbon atoms, such as propylene, to form an olefin oxide, such as propylene oxide. The process involves contacting the olefin with oxygen in the presence of hydrogen and a hydro-oxidation catalyst under reaction conditions; the catalyst comprising gold nanoparticles deposited on a nanoporous titanium-containing support, prepared by depositing a gold-ligand cluster complex onto the support to form a catalyst precursor, and then heating and / or chemically treating the catalyst precursor to form the hydro-oxidation catalyst composition. The hydro-oxidation catalyst exhibits stabilized catalyst activity, enhanced lifetime, and improved hydrogen efficiency.

A nanocluster includes 1 to 7 metal atoms and has at least one ligand, which is associated with at least one of the metal atoms. A method of making a nanocluster consists of combining a nanoparticle, a ligand and a high boiling point solvent to provide a mixture and heating the mixture at a temperature of at least about 125° C. to form a nanocluster with 1 to 7 metal atoms. An ordered array of nanostructures includes a substrate and a plurality of nanostructures on the substrate, where the nanostructures are made by forming a solution of nanoclusters, depositing the solution on a substrate, and heating the substrate.

The invention relates to a method for preparing a sub-nanometer gold cluster molecule. The purification of the prior part is complex. The method of the invention firstly uses chloroauric acid as raw material and adopts a solution method for synthesizing a gold nanometer crystal solution. Then, the gold nanometer crystal solution and amine solution with the molar concentration of 1mM-10M are mixed and react for more than 30min. After the reaction is finished, the centrifugal separation is carried out on the solution to obtain sub-nanometer gold cluster molecular solution. The sub-nanometer gold cluster molecule obtained by the method is monodispersed Au8 cluster molecule. Only common centrifugation is required for separating other impurities. The purification mode is simple.

The invention relates to application of a supported gold cluster catalyst to selective hydrogenation of an aromatic nitrocompound. A preparation method for the catalyst comprises the following steps: with a biological reagent containing mercaptan as a protective agent, preparing a precursor containing a gold cluster in advance; then impregnating a carrier with the precursor; and carrying out drying and roasting at a certain temperature so as to obtain the catalyst which can be directly applied to selective hydrogenation of the aromatic nitrocompound. The catalyst shows excellent activity and selectivity under mild reaction conditions; and compared with supported gold catalysts prepared by using a coprecipitation or deposition-precipitation method, the catalyst prepared in the invention is substantially advantaged in activity and selectivity.

The invention relates to a preparation method and an application of a gold nanocluster with adjustable fluorescence and size. The method adopts mercaptosilane commonly used in the industry as a stabilizer and a reductant, and prepares the gold nanocluster in a way of chloroauric acid photochemical reduction. The method is quick, effective and simple in preparation program, no extra reductant is added, and no reaction produces in a multi-phase environment. The gold nanocluster prepared with the method can be uniformly dispersed in an organic solvent and water, and has excellent photoluminescent performance. The maximum excitation wavelength of the fluorescence of the gold nanocluster is positioned in a visible light region (400-460nm) and the position of an emission peak can be adjusted and controlled in a range of 530-580nm. The gold nanocluster has the characteristics of visible light excitation, large Stokes shift and adjustable fluorescence-emission color and size, thereby having potential application prospects in the fields of fluorescence imaging, marking and catalysis.

The invention relates to a gold cluster catalyst for efficiently catalyzing selective hydrogenation of unsaturated aldehyde ketone to produce unsaturated alcohol. A gold cluster protected by a mercapto group is impregnated on different carriers, and the obtained material is dried and calcined to obtain the catalyst which can be directly applied to the selective hydrogenation reaction of the unsaturated aldehyde ketone. The catalyst has excellent activity and selectivity in a wide temperature range, and allows the unsaturated aldehyde ketone to be efficiently converted into the unsaturated alcohol, and the selectivity under complete conversion conditions reaches up to 90% or above.

The invention discloses a method for correcting a mass spectrometer and / or molecular weight, comprising the following steps: evaporating and plating gold films on a substrate, and bombarding the gold films by laser in the mass spectrometer; or after coating a matrix, a sample under test or the mixture of the matrix and the sample under test on the gold films, bombarding the gold film coated by the sample under test, the gold film coated by the matrix or the gold film coated by the mixture of the matrix and the sample under test by laser in the mass spectrometer, analyzing obtained ions by using the mass spectrometer to obtain a mass spectrogram, and correcting the mass spectrometer and / or the molecular weight of the sample under test according to the theoretical mass of the gold clusters. The method provided by the invention can be used for correcting positive and negative charges. Because the gold clusters without isotopes are used, a series of ion peaks with the mass-charge ratio difference of 197 can be recorded. Because the accurate theoretical mass of the gold is used, the signal of the mass spectrometer and the molecular weight of a sample can be correctly calibrated with deviation reduced to be below 5ppm.

Gold-titania (Au—TiO2) composite aerogels and ambigles were synthesized, characterized, and tested as ambient temperature catalysts for carbon monoxide. Adding alkanethiolate-monolayers-protected gold clusters (with ˜2 nm Au cores) directly to titania sol before gelation yields uniformly dispersed guests in the composite aerogel. The Au guests aggregate to 5 to 10 nm upon calcination to remove alkanethiolate and crystallize amorphous titania to anatase. The resulting composite aerogel exhibits high catalytic activity toward CO oxidation at room temperature at Au particle sizes that are essentially inactive in prior Au—TiO2 catalysts. Transmission electron microscopy illustrates the three-dimensional nature of the catalytic nanoarchitecture in which gold guests contact multiple anatase nanocrystallites.

[Problem] To provide: a gold cluster catalyst which is capable of promoting / controlling a chemical reaction with high catalytic activity and selectivity; and a method for producing the gold cluster catalyst. [Solution] (1) A gold cluster catalyst that is obtained by having a carrier support clusters, each of which is an aggregate of a plurality of gold atoms, by having the carrier support a plurality of gold cluster compounds and then processing the gold cluster compounds on the carrier, each of said gold cluster compounds being stabilized by an organic ligand and comprising a predetermined number of gold atoms. This gold cluster catalyst is characterized in that each of the clusters has a particle diameter of 10 nm or less and is formed substantially only of gold atoms.

The present invention relates to the use of at least one gold nanocluster compound in the manufacture of a pharmaceutical composition or medicament for the prophylactic and / or therapeutic (curative) treatment of a disease, especially a tumor and / or cancer disease. The gold nanocluster compound having a defined particle size, especially a defined size of the core of said gold nanocluster compound, the size ranging from 0.5 nm to 10 nm, the outer limits of this range being included. Especially, the gold nanocluster compounds used possess size-dependent cytotoxic properties, stimulating or inducing cellular death when treating and / or contacting respective cells, especially tumor and / or cancer cells, with the gold nanocluster compounds either via apoptosis or via necrosis, depending on the respective gold cluster size or core size.

Preparation and synthesis of Au25 nanospheres with precise atom number and structure; a preparation method may synthesize the Au25 nanospheres simply and efficiently and may also serve for preparing a supported catalyst and for catalyzing organic reactions, such as Sonogashira coupling reaction. These gold cluster nanomaterials have precise microscopic structure. A synthetic method includes: dissolving chloroauric acid trihydrate (HAuCl4.3H2O) and tetraoctyl ammonium bromide (TOABr) in acetone, adding suitable 2-naphthalenethiol (2-NapSH) ligand, adding a strong reducing agent sodium borohydride for reduction, adding massive 2-naphthalenethiol at suitable temperature to allow for etching reaction to obtain the product Au25(2-NapS)18. The synthetic route related herein has the advantages that the materials are simple and easily accessible, reaction conditions are simple and feasible, and controlling is simple.

A high-efficiency nano-gold-based hydrogenation catalyst and a preparation method thereof belong to the technical field of preparation of a nano-gold-based catalyst with high catalytic activity and high selectivity. In the preparation method, a mixed solution of chloroauric acid and a bifunctional complexing agent is added to a uniform reverse micelle system under stirring conditions, followed by adding a reducing agent, then adding a bifunctional gold cluster complexing agent, and then adding alkali and silicic acid ester, and a highly efficient catalyst in which gold nanoclusters are dispersed in the porous structure of silica is obtained after stirring reaction. This catalyst can efficiently catalyze the hydrogenation reduction of aromatic nitro compounds to corresponding aromatic amines. In the presence of hydrazine hydrate, sodium borohydride and isopropanol, aromatic nitro compounds can be reduced to the corresponding aromatic amines under mild reaction conditions.

The invention relates to a gold cluster / graphene compound catalytic membrane preparation method which comprises the steps: (1) adding deionized water into oxidized graphene to be dispersed evenly andultrasonically dispersing to obtain dispersion liquid; utilizing a hydrothermal reduction method to reduce the oxidized graphene into reduced oxidized graphene rGO and freeze drying to obtain rGO powder; (2) adding the rGO powder into a gold cluster solution protected by thiol ligand, then adding ultrapure water and ultrasonically dispersing to obtain mixed liquid; utilizing vacuum filtration to load the mixed liquid on a base membrane and washing to obtain a gold cluster / graphene compound catalytic membrane. The preparation method disclosed by the invention has the advantages of convenient technological operation, large gold cluster load amount, high catalytic activity, easiness in being recycled and utilized, ability in achieving high-efficiency catalytic membrane construction and good application prospect.

The present invention discloses an application of gold clusters in matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The application utilizes the gold clusters as a matrix,and uses the matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) to analyze small amino acid molecules, cyclodextrin, polyethylene glycol and the like. Resultsindicates that the gold clusters with bovine serum albumin (BSA) as templates are successfully synthesized, and the gold clusters are used as the matrix, molecular weight of the small molecule molecules, the cyclodextrin, the polyethylene glycol and the like are respectively determined by using the MALDI-TOF-MS, and the results broadens scope of use of the gold clusters.

The present invention discloses a preparation method for a gold cluster. The method comprises the following steps that: a gold film is plated on a substrate by evaporation plating; a matrix is coated on the surface of the gold film; the gold film is bombarded by laser to obtain the product. With the preparation method of the present invention, a series of the gold clusters can be obtained, wherein the positive ion mass charge ratio of the gold cluster is 20,000, the negative ion mass charge ratio of the gold cluster is 10,000. The present invention further provides a method for conveniently producing the gold cluster positive ions with the wide mass charge ratio range and the gold cluster negative ions with the wide mass charge ratio range by gold film gasification, wherein the gold film is directly gasified by directly using the laser carried by the mass spectrometer. According to the method of the present invention, the substrate and the gold film can be reused, and the prepared gold clusters can be used for researches of structures, catalytic reactions, mass spectrometry mass calibrations, and the like of the gold cluster.

The invention discloses a preparation method of a gold nanocluster emitting red fluorescence and a detection method for penicillamine and also discloses a sensitive detection method for penicillaminein actual water samples and urine. The method for preparing the gold cluster is simple, the reaction condition is mild, the obtained gold cluster has good light stability and water solubility and highquantum yield. The gold cluster is combined with copper ions to build a fluorescence-quenching sensing system which can be used for fluorescence-enhanced detection of the penicillamine; the detectionmethod for the penicillamine is low in detection limit, good in selectivity and strong in interference resistance and can be used for detecting the penicillamine in the complex actual samples; when the samples contain the penicillamine, the existence of the penicillamine in the actual samples can be judged only by using a simple handheld ultraviolet lamp to observe the change of the color of thesample solution by the naked eyes.

The invention discloses a preparation method of a gold cluster / TiO2 composite nano material, which comprises the following steps of (a) placing TiO2 nanopowder in chloroauric acid aqueous solution and conducting ultrasonic dispersion to obtain solution to be reacted; and (b) heating the solution to be reacted at 125-135 DEG C, adding trisodium citrate solution in an one-off mode under stirring when solution boils, continuously stirring when solution is changed from white to purple, and finally obtaining the gold cluster / TiO2 composite nano material in which TiO2 loads gold cluster structure. The obtained composite nano material has high catalytic activity compared with pure TiO2 nanoparticles, modified electrodes papered by using the composite nano material have strong sensibilization on electrochemical luminescence of luminol, dissolved oxygen and hydrogen peroxide can be sensitively detected, detection limit of the dissolved oxygen can achieve 2mu g / L, and detection limit of the hydrogen peroxide can achieve 5.54'10-12mol / L. Compared with reports capable of consulting at present, detection sensitivity of the dissolved oxygen and the hydrogen peroxide is obviously improved, and unexpected technique effects are achieved.

The invention relates to a mass spectrometric detection method based on a paper target. The method uses paper (filter paper, printing paper and the like) as a sample target. Laser analytical ionization and mass spectrometric detection of sample molecules are realized with the aid of a conventional organic matrix or a gold cluster nanomaterial. According to the invention, the sample carrying function of the paper target and the auxiliary ionization function of an organic or inorganic matrix on the sample are combined; and the method has the advantages of convenient sampling, easy sample storageand transportation, high detection sensitivity and the like, effectively avoids the 'coffee ring' effect of the organic matrix, and is suitable for fast, high-sensitivity and high throughput detection of a variety of biomolecules, drug molecules, environmental pollutant molecules (sugars, nucleosides, natural products, basic drugs, peptides and the like).

A synthetic method of simple gold nanoparticle catalysts having a controllable dimension, and applications of the catalysts are disclosed. Aurochloric acid is adopted as a gold source, poly(vinyl alcohol) is adopted as a protective agent, sodium borohydride is adopted as a reductant, and a direct reduction process is adopted to prepare a gold nanoparticle material. Aurochloric acid hydrate is hydrolyzed in water to form free Au<3+>. A series of gold clusters and gold nanoparticles having different dimensions and uniform particle sizes can be obtained through adjusting the concentration of Au<3+> and a mole ratio of the Au<3+> to the reductant. A carrier can be directly loaded with obtained gold colloid through a colloid process. The catalysts can be used for researches for understanding base mechanism of gold nanometer catalysts, and can be applied in simple catalytic reactions. Problems that dimensions are non-uniform and a gold utilization rate is low in a gold nanoparticle preparing process are overcome. Complex gold cluster and gold nanoparticle preparing methods at present are optimized. The cost is reduced. The method and the applications have certain economic value and research value.

The invention discloses a preparation method of a gold nanomaterial synthesized by dithiothreitol. The preparation method comprises the following steps: dithiothreitol and chloroauric acid are uniformly mixed according to a volume ratio of 3: 1, and are dissolved in ultrapure water to obtain raw material mixture solution; the raw material mixture solution is stirred by 10-30 min at room temperature to obtain nanoparticle dispersion liquid; the nanoparticle dispersion liquid in the step (2) is dialyzed by 24 h in a dialyzing bag; and solution in the dialyzing bag is frozen and dried in vacuum to obtain the gold nanomaterial synthesized by dithiothreitol. The gold nanomaterial is convenient to synthesize, excellent and stable in fluorescence performance and excellent in biologic compatibility; and a gold cluster is applied, so that users can wrap external source genes and lead into target cells to finish the gene treatment purpose.

The invention provides core-shell structured gold cluster-carbon dot nano-particles as well as a preparation method and application thereof. According to the gold cluster-carbon dot nano-particles, carbon dots are taken as a template, a nano gold cluster exists inside the template, the nano gold cluster and the carbon dots are connected by virtue of Au-N coordinate bonds, and the particle size of the gold cluster-carbon dot nano-particles is 3-5nm. The preparation method of the gold cluster-carbon dot nano-particles comprises the following steps: by taking carbon dots synthesized from polyethylene-polyamine and citric acid as a template, adding chloroauric acid, enabling the components to react in the presence of a reducing agent, so as to obtain the gold cluster-carbon dot nano-particles. The gold cluster-carbon dot nano-particles provided by the invention are uniform in particle size and good in dispersity, the nano gold cluster and the carbon dots are connected by virtue of the Au-N coordinate bonds, and the gold cluster is kept stable and is difficult to aggregate. The gold cluster-carbon dot nano-particles provided by the invention can be applied to intracellular oxidative stress amplification for tumor treatment.

A gold cluster catalyst is capable of promoting / controlling a chemical reaction with high catalytic activity and selectivity. The gold cluster catalyst has a carrier supporting clusters, each of which is an aggregate of a plurality of gold atoms, which can be obtained by providing the carrier supporting a plurality of gold cluster compounds and then processing the gold cluster compounds on the carrier, in which each of the gold cluster compounds is stabilized by an organic ligand and including a predetermined number of gold atoms. In the gold cluster catalyst, each of the clusters may have a particle diameter of 10 nm or less and be formed substantially only of gold atoms.

Disclosed are a pharmaceutical use of a gold cluster and a substance containing the gold cluster and the preparation method and use thereof. The gold cluster and substance containing the gold cluster can inhibit the aggregation of Aβ and α-syn, has excellent effects on the levels of cell models and animal models, and can be used to prepare drugs for preventing and treating Alzheimer's disease and / or Parkinson's disease.

The invention discloses a nine-core gold cluster compound and a synthesis method thereof, relates to a gold cluster compound, and provides the nine-core gold cluster compound which is higher in stability and capable of emitting strong light in a liquid state, as well as a synthesis method thereof. The molecular formula of the nine-core gold cluster compound is [Au9(PC17NH13)6](BF4)3. The synthesis method comprises the following steps: mixing diphenylphosphine and butyl lithium in tetrahydrofuran to obtain a solution A; dissolving 2,6-dichloropyridine in tetrahydrofuran, and adding into the solution A; pumping out the solvent, adding water for carrying out quenching reaction, using dichloromethane to extract, collecting an organic layer, separating by a silicagel column to obtain 2,6-diphenyl phosphino-pyridine; dissolving in dichloromethane, adding Me2SAuCl, stirring, adding AgBF4, filtering, removing the solvent to obtain a compound [(PNP)2Au2](BF4)2; dissolving the compound [(PNP)2Au2](BF4)2 in dichloromethane, and adding a methanol solution which is dissolved with KOH and NaBF4, removing the solvent after refluxing, and extracting by dichloromethane to obtain the nine-core gold cluster compound.

The invention discloses an atom-accurate nano-gold cluster material radiotherapy sensitizer, and belongs to the crossing field of nano material chemistry and biochemistry. Levonorgestrel good in biocompatibility serves as a protective ligand, and a gold nano cluster which is high in yield, superior in fluorescence property and accurate in atom size is synthesized through a room-temperature volatilization one-pot method. The chemical formula of the nano-gold cluster is C168H216 Au8O16 (abbreviated as: Au8NC), and belongs to a triclinic system, and the space group is a chiral space group P1. Thegold nano cluster has strong yellow-green fluorescence at room temperature, the fluorescence quantum yield is 58.7%, the gold nano cluster has a small size (-2 nm) and good dispersibility and can beused for bright cell imaging. The nano-gold cluster material can serve as a radiotherapy sensitizer to enhance the radiotherapy sensitization effect.

Disclosed is the use of a gold cluster or a gold cluster-containing substance in the preparation of a drug for preventing and / or treating glaucoma.

The invention relates to a gold cluster-titanium dioxide-graphene composite material capable of being used for visible-light efficient sterilization and a preparing method and application thereof, and belongs to the technical field of composite materials. The preparing method includes the steps that according to the composite material, gold clusters and titanium dioxide nanometer particles are connected in an electrostatic attraction mode, then a compound of the gold clusters and titanium dioxide is connected on the graphene through the functional groups on the graphene, and the mass ratio of the gold clusters to the titanium dioxide to the graphene is (2.5-6.4)%:(78.6-92.5)%:(4.2-15)%. The invention further provides the preparing method and application of the composite material. According to the composite material, the titanium dioxide can be excited by visible light through the visible light absorption performance of the gold clusters, excited electrons are transferred to the graphene through the super-electronic conduction property of the graphene, the recombination rate of electrons and holes are reduced, and therefore the antibacterial effect of the composite material is effectively improved. The killing rate of the composite material for escherichia coli and staphylococcus aureus under the visible light can be 80%.

The invention relates to a dual-emission gold cluster ratiometric fluorescent probe and a preparation method thereof, and a doxycycline detection method, wherein the dual-emission gold cluster material is prepared by using bovine serum albumin to modify a gold cluster, and the dual-emission gold cluster material has fluorescence emission peaks at 480 nm and 640 nm under excitation of 390 nm. The double-emission gold cluster material is applied to high-selectivity and high-sensitivity detection of doxycycline as a ratiometric fluorescent probe. The invention also discloses an application of the double-emission gold cluster material in selective detection of doxycycline. The detection method can effectively eliminate system errors and has the advantages of being low in detection limit, good in accuracy, simple and rapid in detection and the like.

The invention provides a load-type gold cluster catalyst for catalytic conversion of CO2 prepared basic chemicals. In a gold cluster, the number of gold atoms is 9, 11, 23, 24, 25, 28 and 38, the masscontent of the gold cluster is 0.1 wt%-3 wt%, and a carrier is transition metal oxide. The load-type gold cluster catalyst has the beneficial effects that common chloroauric acid and organic amine are utilized as reactants and the metal oxide carrier is utilized, through chemical coordination and reduction and a ultrasonic load method, thus the load-type gold cluster catalyst material is prepared, the gold content is adjustable in the certain range, and different catalysis properties can be achieved when different carriers are loaded, for example, the load-type gold cluster catalyst materialshows excellent catalytic performance in the aspect of catalytic conversion of the CO2 prepared basic chemicals. The load-type gold cluster catalyst material has many advantages and can be subjected to industrial mass production. In the catalyst of a method, the content of gold is small, the efficiency is high, the cost is low, and environment pollution is small. The invention discloses a preparation method of the load-type gold cluster catalyst.