12 results about "Gold cluster" patented technology

The invention discloses a gold nanocluster electrogenerated chemiluminescence probe which is a multifunctional gold nanocluster obtained by taking a 2-sulfydryl-1, 3, 4-thiadiazole ligand as a reducing agent or a protective agent. Comprising a solid-phase probe with a gold cluster modified on an electrode; or the gold cluster is independent of the electrode and is a liquid-phase probe dissolved in the electrolyte during use. The obtained electrogenerated chemiluminescence gold nanocluster probe can generate an electrogenerated chemiluminescence signal under the condition of no co-reactant, and is relatively low in luminescence potential, high in quantum yield and good in biocompatibility.

This invention discloses a method for preparing and applying a gold cluster scintillator protected by a stable luminescent free radical ligand. The scintillator material uses (3,5-dichloro-4-pyridine)bis(2,4,6-trichlorobenzene)methyl free radical (PyBTM) as a ligand, and a chain-like tetranuclear free radical cluster is constructed using a one-pot method. The chemical formula of the compound is [Au4(PNP)2(PyBTM)2](SbF6)4, belonging to the triclinic crystal system, space group R-3. This free radical cluster scintillator achieves 100% theoretical exciton utilization and a short radiation decay lifetime due to its unique doublet emission mechanism. These properties make it an ideal candidate material for overcoming the contradiction between high luminous yield and fast response in traditional scintillators. Due to the excellent thermal and water-oxygen stability of this system, it can be fabricated into a scintillator screen to further achieve high-quality X-ray imaging with a spatial resolution of up to 31 LP·mm. ‑1 This provides a general design strategy for high-performance radiation detection materials.

The invention discloses a method for ratio-dependent fluorescence detection of enrofloxacin based on a new composite nano carbon dot-gold cluster material and application, and belongs to the technical field of advanced non-ferrous metal nano new materials and new material detection. The new composite nano carbon dot-gold cluster material AuNCs-CDs can be prepared by mixing gold nano cluster seeds and ascorbic acid according to a certain proportion and carrying out microwave heating; under the same excitation wavelength, the AuNCs coated CDs have two emission peaks of 440 nm and 640 nm. The method comprises the following steps: adding enrofloxacin with different concentrations into an AuNCs (at) CDs solution, and measuring the fluorescence intensity ratio I440 / I640 of the AuNCs (at) CDs; and drawing a standard curve according to the relationship between the concentration of the enrofloxacin solution and the fluorescence intensity ratio of the AuNCs coated CDs solution, so as to detect the concentration of the enrofloxacin. In addition, the method can be applied to experimental recovery rate detection of enrofloxacin in an actual sample. The method disclosed by the invention has high sensitivity and selectivity, is simple and rapid, does not need any pretreatment, and shows an extremely wide application prospect in many fields such as biomedical detection, environmental monitoring, food safety analysis and the like.

This invention relates to a three-emission ratio fluorescence nanosensor for detecting tetracycline and its preparation method. The sensor uses a carbon dot-gold cluster nanocomposite material as the fluorescence signal. The synthesis steps and detection process of the carbon dot-gold cluster nanocomposite material in this invention are simple, convenient, and rapid, exhibiting rich fluorescence color changes. It does not require the assistance of complexes or coupling reagents. By constructing a three-emission ratio fluorescence sensor, the goal of highly sensitive and selective detection of tetracycline can be achieved.

This invention provides a ligand for gold cluster nanozymes and a method for preparing self-assembled gold cluster nanozyme hydrogels using the ligand. The method includes the steps of synthesizing gold cluster nanozymes in an aqueous phase using the ligand via a one-step process, adding the gold cluster nanozymes to a completely dissolved gelling agent hot solution, and allowing it to cool and stand at room temperature to obtain the self-assembled gold cluster nanozyme hydrogel. This invention also provides the self-assembled gold cluster nanozyme hydrogel obtained by the described method. The gold cluster nanozyme ligand of this invention possesses both reducing and assembly properties. The method for preparing hydrogels using it is simple and easy to implement, with mild reaction conditions, requiring no complex equipment or other cross-linking agents. It not only improves the uniformity and stability of gold cluster nanozymes in hydrogels but also endows the hydrogels with excellent biocompatibility and peroxidase-like activity, among other biological properties.

The invention discloses a method for selectively preparing a gold cluster polycrystalline phase based on halogenation engineering, and belongs to the crossing field of coordination chemistry and material science. The crystal structure of the Au4 cluster is regulated and controlled through a ligand halogenation engineering strategy. The R / Sau4-H cluster before halogenation only has one crystal structure, and after the ligand is modified by a halogenation engineering strategy, weak interaction among molecules can be selectively activated by controlling the types of solvents, so that the polycrystalline phase structure of the cluster is accurately regulated and controlled. F atoms are introduced, so that two polycrystalline phase cluster enantiomers R / Sau4-F and (R / Sau4-F) 4 can be obtained; three kinds of polycrystalline phase cluster enantiomers, namely R / Sau4-Cl, (R / Sau4-Cl) 3 and (R / Sau4-Cl) n, can be obtained by introducing Cl atoms; two polycrystalline phase cluster enantiomers R / Sau4-Br and (R / Sau4-Br) 3 can be obtained by introducing Br atoms. The synthesis of the gold cluster polycrystal phase can be selectively controlled, and the accurate regulation and control of the crystal phase structure are realized.

The invention provides a preparation method of a gold cluster / titanium dioxide nano photocatalyst, belongs to the technical field of inorganic nano materials, and can solve the problem of low selectivity of 2, 5-furandicarboxaldehyde under visible light. According to the technical scheme, the preparation method comprises the following steps: (1) uniformly dispersing a ligand in deionized water to obtain a solution A; (2) uniformly dispersing chloroauric acid in deionized water to obtain a solution B; (3) gradually adding the solution A into the solution B under stirring, and performing heat treatment at 70 DEG C to obtain a gold cluster solution C; (4) uniformly dispersing the titanium precursor, a catalyst and hydrogen peroxide in deionized water, and performing hydrothermal reaction at 180 DEG C to obtain a titanium dioxide nano material; (5) uniformly dispersing a titanium dioxide nano material and thiohydracrylic acid in deionized water, adding the solution C, uniformly mixing, and carrying out ultraviolet lamp illumination to obtain a solution D; and (6) centrifuging the solution D, washing with deionized water, drying at 60 DEG C to obtain golden powder, and performing vacuum heat treatment to obtain the gold cluster / titanium dioxide nano photocatalyst. The selectivity of the obtained photocatalytic material to 2, 5-furandicarboxaldehyde reaches 65%.

The invention discloses a gold cluster capable of relieving tumor hypoxia and realizing photothermal and photodynamic therapy, and belongs to the crossing field of nanomaterial chemistry and biomedicine. According to the invention, fluorine-containing substance 4-trifluoromethyl thiophenol is used as a fluorine-containing protective ligand, and the atomic-scale precise gold nano-cluster with near-infrared two-zone emission characteristic is synthesized by a one-pot method. The chemical formula of the compound is C126H72Au25F54S18 (abbreviated as Au25 (CF3SPh) 18), the compound belongs to a monoclinic system, and the space group is a chiral space group P21. The nano gold cluster has a relatively small size (-2.3 nm) and good dispersity; the fluorescent probe can be excited by near-infrared light, the position of an emission peak is 1092 nm, and the fluorescent probe is suitable for near-infrared two-region fluorescence imaging of a mouse living body. The nanogold cluster material can relieve tumor hypoxia, can play a synergistic treatment role as a photothermal agent and a photosensitizer, and has efficient anti-tumor performance.

The application discloses a method for detecting enrofloxacin based on composite nanometer carbon dot-gold cluster new material ratio type fluorescence and application, and belongs to the field of advanced non-ferrous metal nanometer new materials and new material detection technology. The composite nanometer carbon dot-gold cluster new material AuNCs@CDs can be prepared by mixing gold nanometer cluster seeds and ascorbic acid in a certain proportion and microwave heating; under the same excitation wavelength, the AuNCs@CDs has two emission peaks of 440 nm and 640 nm. Different concentrations of enrofloxacin are added into the AuNCs@CDs solution, the fluorescence intensity ratio I 440 / I 640 of the AuNCs@CDs is measured; and a standard curve is drawn according to the relationship between the enrofloxacin solution concentration and the fluorescence intensity ratio of the AuNCs@CDs solution, so that the enrofloxacin concentration can be detected. In addition, the method can be applied to the experimental recovery rate detection of enrofloxacin in actual samples. The method has high sensitivity and selectivity, is simple and rapid, does not need any pretreatment, and shows extremely broad application prospects in many fields such as biomedical detection, environmental monitoring, food safety analysis and the like.

The application belongs to the technical field of heavy metal ion detection, and specifically discloses a preparation method of an ionic liquid modified nanometer gold cluster material and application of the material in detection of heavy metal ion cadmium. The application synthesizes nanometer gold clusters emitting red fluorescence by taking bovine serum albumin as a stabilizer and a reducing agent, and synthesizes an ionic liquid modified nanometer gold cluster composite material by utilizing electrostatic interaction between an imidazole ionic liquid and the BSA. Due to unique coordination between cadmium ions and the imidazole ionic liquid, the cadmium ions can effectively enhance the fluorescence intensity of the ionic liquid modified nanometer gold cluster composite material, and can be applied to detection of cadmium ions in actual samples, thereby providing a new idea for convenient detection of cadmium ions in complex substrates.

The present invention relates to superstructured gold clusters Au-pX, consisting of gold atoms and at least one ligand, where said gold atoms in said cluster are in a number between 2 and 100 or the dimensions of said cluster are smaller than 2 nm, for use in the treatment of pathologies related to oxidative stress. In a preferred embodiment, said Au-pX superstructured gold clusters are for use in the treatment of Friedreich's ataxia.

This invention discloses a gold cluster zinc oxide composite photocatalyst for methane oxidative coupling reactions, its preparation method, and its applications. The gold cluster zinc oxide composite photocatalyst comprises zinc oxide and gold clusters uniformly distributed on its surface. The gold clusters have a particle size ranging from 0.9 to 1.3 nm, and the mass percentage of the gold clusters in the composite photocatalyst is 0.3 to 1.1 wt.%. The prepared gold cluster zinc oxide composite photocatalyst exhibits excellent low-temperature catalytic performance and stability, enabling the high-rate, high-selectivity photo-driven conversion of methane to C2-C4 hydrocarbons at low temperatures in a closed reactor, effectively suppressing the side reaction of excessive methane oxidation to carbon dioxide. This invention also provides a method for preparing the gold cluster zinc oxide composite photocatalyst, which is simple in process, uses simple raw materials, and is inexpensive.