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Nano-gold cluster material radiotherapy sensitizer

A nano-gold cluster and Å technology, which is applied in the cross-field of nanomaterial chemistry and biochemistry, can solve problems that hinder the application and development of gold nanoparticles or gold nanocluster radiotherapy sensitizers, achieve good application value, reduce X Radiation dose, effect of reducing side effects

Active Publication Date: 2019-09-06
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently reported studies on gold nanoparticles or gold nanoclusters as radiosensitizers mainly focus on their performance. However, how to correlate their excellent performance with the inner core structure and ligands is still a difficult problem, which greatly hinders the development of radiosensitizers. The application and development of gold nanoparticles or gold nanoclusters as radiosensitizers, so designing and synthesizing gold nanoclusters with precise atoms, definite structure, and good biocompatibility as radiosensitizers is the focus of research in the field of radiosensitization One, it has a good application prospect in radiation therapy

Method used

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  • Nano-gold cluster material radiotherapy sensitizer

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Embodiment 1

[0018] Embodiment 1: the synthesis of nano-gold cluster material of the present invention

[0019] Levonorgestrel was dissolved in dichloromethane (DCM) and acetonitrile (CH 3 CN) in the mixed solution, stir rapidly; Add triethylamine (Et 3 N), stirred the reaction, then added Me 2 SAuCl continued to react with stirring at room temperature. After the reaction was completed, the reaction solution was placed at room temperature to avoid light volatilization. After 1 day, yellow-green block crystals were obtained, with a yield of 78.7%. Filter, wash with acetonitrile, and dry at room temperature for its property test material .

Embodiment 2

[0020] Embodiment 2: The nano-gold cluster material of the present invention is used as a radiosensitizer

[0021] Take the nano-gold cluster material sample of the present invention prepared in Example 1, dissolve it in a small amount of ethanol, add it into the culture medium and sonicate it evenly, use the culture medium containing the material in the cell cloning experiment, and carry out different dosages for different groups X-ray processing. see results Figure 6 , it can be seen that Au 8 The cell apoptosis in the NC+X-ray experimental group was the most significant.

[0022] The nano-gold cluster material of the present invention obtained in Example 1 is further characterized, and the process is as follows:

[0023] (1) Determination of crystal structure

[0024] The X-ray single crystal diffraction data of the complexes were measured on a Rigaku XtaLAB Pro single crystal diffractometer with a single crystal sample of appropriate size. Data with Mo-Kα rays The ...

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Abstract

The invention discloses an atom-accurate nano-gold cluster material radiotherapy sensitizer, and belongs to the crossing field of nano material chemistry and biochemistry. Levonorgestrel good in biocompatibility serves as a protective ligand, and a gold nano cluster which is high in yield, superior in fluorescence property and accurate in atom size is synthesized through a room-temperature volatilization one-pot method. The chemical formula of the nano-gold cluster is C168H216 Au8O16 (abbreviated as: Au8NC), and belongs to a triclinic system, and the space group is a chiral space group P1. Thegold nano cluster has strong yellow-green fluorescence at room temperature, the fluorescence quantum yield is 58.7%, the gold nano cluster has a small size (-2 nm) and good dispersibility and can beused for bright cell imaging. The nano-gold cluster material can serve as a radiotherapy sensitizer to enhance the radiotherapy sensitization effect.

Description

technical field [0001] The invention belongs to the intersection field of nanometer material chemistry and biochemistry, and in particular relates to an atomically precise nanometer gold cluster material radiotherapy sensitizer. Background technique [0002] Radiation therapy is one of the three main therapeutic strategies for the clinical treatment of local solid tumors, and more than 50% of patients have received radiation therapy in the process of fighting cancer. However, high-intensity radiation during treatment can not only kill tumor cells, but also cause inevitable damage to surrounding normal tissues. Therefore, how to develop a radiosensitizer with excellent performance to maximize the radiation dose to cancer cells and reduce the damage to normal cells has become an urgent problem to be solved. The research and application of radiosensitizing drugs such as semiconductor materials and nanostructures of high-Z elements have achieved remarkable results. However, the...

Claims

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Application Information

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IPC IPC(8): C07F1/12C09K11/06B82Y20/00A61K41/00A61P35/00
CPCA61K41/0038A61P35/00B82Y20/00C07F1/12C09K11/06C09K2211/188
Inventor 臧双全赵雪利贾桐桐王朝阳
Owner ZHENGZHOU UNIV
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