76results about "Gold organic compounds" patented technology

Provides a type of gold(III) complex supported by tetradentate ligand having a structure of formula (I). The light-emitting device prepared by using the complex as a light-emitting layer material or dopant in the light-emitting device has a high external quantum efficiency, and a low efficiency roll-off. In addition, the preparation process of the tetradentate ligand provided in the present disclosure is simple and the yield is satisfactory. More importantly, the preparation reaction of the material is controllable and stable, and has a good reproducibility, and is suitable for industrial application.

The invention discloses a gold nanocluster and application thereof in electro-catalysis of carbon dioxide reaction. The synthesis method comprises the following synthesis steps: firstly, adding a gold source into a tetrahydrofuran solution, stirring for five minutes, then adding tetra-n-octyl ammonium bromide, stirring until the solution is dark red, adding cyclohexanol, stirring until the solution is transparent, then adding a reducing agent, stirring overnight, then washing with methanol for multiple times, dissolving a crude product into a small amount of methylbenzene, and drying to obtain a target product. And adding a certain amount of cyclohexanol and 3 (2-furyl) phosphorus again, slowly stirring at 60 DEG C for 12 hours to obtain a crude product, washing with methanol for several times again, and purifying and separating to obtain the gold nanocluster. The gold nanocluster provided by the invention has the characteristics of novel structure, good stability, easy synthesis and high yield, and has excellent catalytic performance in electrocatalytic carbon dioxide reaction.

Conductive ink compositions comprising gold complexes are provided. Also provided are methods of preparing the conductive ink compositions, methods of forming conductive structures from the conductive ink compositions, and structures formed from the conductive ink compositions. The conductive ink compositions preferably comprise a gold metal, an alkylamine ligand, and a solvent. The conductive ink compositions can be used to form conductive structures comprising gold, for example by inkjet or other printing methods, at temperatures of 300° C. or less. Such conductive structures can be formed on a variety of substrates.

The invention discloses preparation of a methoxyl derivative and application of the methoxyl derivative in pharmacy. The methoxy derivative as shown in the formula I has good anti-tumor activity, and the anti-tumor effect is effectively achieved through the growth inhibition and killing effect on tumor cells. The methoxyl derivative not only can inhibit the growth of CT26 transplanted tumors, but also can promote the activation and infiltration of lymphocytes in an in-vivo tumor microenvironment. Meanwhile, the compound also has a remarkable inhibiting effect on the growth of mouse colon cancer CT26 cell strains in vitro.

A compound is described as having a triplet excited state and a singlet excited state; wherein the triplet excited state comprises a lowest energy triplet sublevel, a middle energy triplet sublevel, and a highest energy triplet sublevel; and wherein an energy separation between the highest energy triplet sublevel and the lowest energy triplet sublevel (ZFS) is greater than an energy separation between the singlet excited state and a the lowest energy triplet sublevel. Also described is a compound represented by the following Formula I. These compounds should find application as luminescent materials in organic light emitting diodes (OLEDs).

A compound is described as having a triplet excited state and a singlet excited state; wherein the triplet excited state comprises a lowest energy triplet sublevel, a middle energy triplet sublevel, and a highest energy triplet sublevel; and wherein an energy separation between the highest energy triplet sublevel and the lowest energy triplet sublevel (ZFS) is greater than an energy separation between the singlet excited state and a the lowest energy triplet sublevel. Also described is a compound represented by the following Formula I. These compounds should find application as luminescent materials in organic light emitting diodes (OLEDs).

The invention relates to ylide-functionalized phosphane ligands, the production of same and use in transition metal compounds, as well as the use of same as catalysts in organic reactions.

Conductive ink compositions comprising gold complexes are provided. Also provided are methods of preparing the conductive ink compositions, methods of forming conductive structures from the conductive ink compositions, and structures formed from the conductive ink compositions. The conductive ink compositions preferably comprise a gold metal, an alkylamine ligand, and a solvent. The conductive ink compositions can be used to form conductive structures comprising gold, for example by inkjet or other printing methods, at temperatures of 300 °C or less. Such conductive structures can be formed on a variety of substrates.

Disclosed are compounds, particularly compounds capable of sensing and / or imaging glycans (such as sialic acid, etc., such as mono-sialic acid, di-sialic acid, tri-sialic acid, polysialic acid) and / or cancer cells and capable of distinguishing between cancer cells and normal cells. The compound is a d8 or d10 metal complex or a salt thereof. The metal complexes may bind to glycans (such as, for example, monosialic acid, disialic acid, trisialic acid, and polysialic acid, etc.) and / or cancer cells. The combination interaction induces the accumulation of the metal complex and the self-assembly of the supramolecules, thereby causing the change of the photophysical properties of the metal complex.

The invention discloses a compound A. The structural formula (I) of the compound A is shown in the specification. The invention also discloses a preparation method of the compound A and application of the compound A as a metal nanocluster ligand. The invention further discloses a metal nanocluster, and the general molecular formula of the metal nanocluster is Au10Cu6 (PNP) 4Cl6. The invention also discloses a preparation method of the metal nanocluster, which comprises the following steps: uniformly mixing a gold source, a copper source and a solvent, uniformly mixing with a PNP ligand, adding a reducing agent, and reacting to obtain the metal nanocluster. The invention also discloses the metal nanocluster and application of the metal nanocluster prepared by the method as a catalyst. According to the invention, the compound A is successfully prepared, and the metal nanocluster is successfully prepared by taking the compound A as a ligand, and the metal nanocluster has good catalytic performance and can catalyze an oxidation reaction under mild conditions.

The present invention provides a gold complex exhibiting aggregation-induced emission properties, as well as its preparation method and application, belonging to the field of organometallic compounds. The structural formula of the gold complex described herein is as follows: #imgabs0#. The gold complex prepared by the present invention effectively inhibits fungal growth at low concentrations, exhibiting strong antifungal activity with minimal toxicity to normal cells. It exhibits excellent biocompatibility and enables fluorescent visualization of fungal infections, providing strong diagnostic support.

A compound including a first ligand LA of Formula I,is provided. In Formula I, moiety A is a monocyclic ring or a polycyclic fused ring system; moiety B is a polycyclic fused ring system having at least three rings; each of Z1 to Z4 is C or N; K is a direct bond or a linking group; each R substituent is hydrogen or a General Substituent defined herein; at least one RA includes a non-aromatic polycyclic group; LA is coordinated to a metal M; Z1 forms a dative bond with M; and Z2 forms an anionic bond to K. Formulations, OLEDs, and consumer products containing the compound are also provided.

The application discloses a carbene currency metal complex and preparation and application thereof, and belongs to the technical field of electroluminescent materials.The complex structure features of the application are that a monovalent currency metal is taken as a core, and a cyclic alkyl amino carbene ligand and a carbazole ligand with a five-membered ring side wing group are connected respectively.The carbene ligand with the five-membered ring side wing group in the complex has the characteristics of simple and efficient synthesis and cheap and easily available raw materials, and can solve the current design problem of the carbene ligand.In addition, the carbene currency metal complex has the characteristics of thermal activation delayed fluorescence, and has the advantages of high photo-induced quantum yield, short exciton lifetime and high efficient device performance, and provides a new scheme for constructing an organic electroluminescent device with high efficiency and low cost.

The invention discloses a Salen ligand, a carbene compound and a preparation method of the Salen ligand and the carbene compound, and belongs to the technical field of chemical synthesis. The chemical structural formula of the Salen ligand is shown as a formula I, and the formula I is # imgabs0 #; in the formula I, M comprises any one of Pd, Ni, Cu and Zn; r comprises any one of methyl, ethyl and n-butyl; r'comprises any one of C1-C5 alkyl, phenyl and biphenyl; and X comprises PF6. Salen and carbene are combined to realize concerted catalysis, stability enhancement and multifunctional integration, the structure adjustability and metal coordination capability of the Salen ligand are retained, high reaction activity and stability of carbene are introduced, a multifunctional composite system is formed, the catalytic activity of the single Salen ligand is remarkably improved, and the Salen ligand has a wide application prospect. The application field of the Salen ligand is widened, and the technical problem that Salen is rarely researched in the carbene field is solved.

The application belongs to the cross field of coordination chemistry and nanomaterials, and discloses a super-stable strong luminescent N-heterocyclic carbene-protected chiral heterometallic cluster and a preparation method thereof. 58.5 H 59 AuBr4ClCu4F6N8OP (abbreviated as: R / S -NHC py -AuCu4 ‑ Br) belongs to an orthorhombic system, and the space group is a chiral space group P 212121. Another chemical formula of the nanocluster is C 58 H 58 AuCu4F6I4N8P (abbreviated as: R / S -NHC py -AuCu4 ‑ I) belongs to an orthorhombic system, and the space group is a chiral space group I 41. The cluster has a structure that can be stable to 150 DEG C in air. R / S -NHC py -AuCu4 ‑ Br has strong orange luminescence at room temperature in air, and the luminescence quantum yield is 58%. The chiral structure and strong luminescence make it have strong chiral luminescence characteristics, and it can have good application prospects in the fields of holographic projection, information storage and cell imaging.

The application discloses a SERS probe for monitoring redox reactions and a preparation method and application thereof. A metal complex TEPE-Au is prepared first in the application, and a chemical structural formula of the metal complex is shown as formula I. The TEPE-Au complex has obvious Raman characteristic peaks in a silent zone, and exhibits high sensitivity and high resolution, and can be used as a silent zone reporter molecule. After the TEPE-Au complex is made into a SERS probe and combined with a SERS detection technology, the SERS probe can be used for monitoring redox reactions, and can also be used for detecting the concentration or content of alkaline phosphatase, and has good application prospects in the fields of biological detection, chemical detection or medical diagnosis, etc.

An organometallic compound represented by Formula 1wherein, M1 to M4 are each independently a first-row transition metal, a second-row transition metal, or a third-row transition metal; X1 and X2 are each independently C(R5)(R6), Si(R5)(R6), N(R5), O, S, Se, or Te; W1 to W4 are each independently N(R7)(R8), P(R7)(R8), S(R7), a C5-C60 carbocyclic group unsubstituted or substituted with at least one R10a, or a C1-C60 heterocyclic group unsubstituted or substituted with at least one R10a; L1 to L6 are each independently a C1-C30 alkylene group unsubstituted or substituted with at least one R10a, a C5-C60 carbocyclic group unsubstituted or substituted with at least one R10a, or a C1-C60 heterocyclic group unsubstituted or substituted with at least one R10a, a3 to a6 are each independently an integer from 0 to 3, and R1 to R8 and R10a in Formula 1 are as described herein.

To provide a material with large two-photon absorption cross-sectional area.SOLUTION: A two-photon absorption material is provided, containing a molecule having a thiolate ligand and a metal thiolate complex bound to a surface of a small atomic cluster nucleus. An element constituting the small atomic cluster nucleus and a metal element constituting the metal thiolate complex are Au, and the small atomic cluster nucleus of the molecule of the metal thiolate complex has an atomic number in a range of 10-56.SELECTED DRAWING: None

Provided are compounds of Formula (I) wherein P is a phosphorescent emitter, F is a fluorescent emitter, and L is a covalent linker. Also provided are formulations comprising these compounds. Further provided are OLEDs and related consumer products that utilize these compounds

The invention discloses a method for selectively preparing a gold cluster polycrystalline phase based on halogenation engineering, and belongs to the crossing field of coordination chemistry and material science. The crystal structure of the Au4 cluster is regulated and controlled through a ligand halogenation engineering strategy. The R / Sau4-H cluster before halogenation only has one crystal structure, and after the ligand is modified by a halogenation engineering strategy, weak interaction among molecules can be selectively activated by controlling the types of solvents, so that the polycrystalline phase structure of the cluster is accurately regulated and controlled. F atoms are introduced, so that two polycrystalline phase cluster enantiomers R / Sau4-F and (R / Sau4-F) 4 can be obtained; three kinds of polycrystalline phase cluster enantiomers, namely R / Sau4-Cl, (R / Sau4-Cl) 3 and (R / Sau4-Cl) n, can be obtained by introducing Cl atoms; two polycrystalline phase cluster enantiomers R / Sau4-Br and (R / Sau4-Br) 3 can be obtained by introducing Br atoms. The synthesis of the gold cluster polycrystal phase can be selectively controlled, and the accurate regulation and control of the crystal phase structure are realized.

The invention relates to ylide-functionalized phosphine ligands, their production and use in transition metal compounds, and their use as catalysts in organic reactions.

A compound having a first ligand LA wherein the first ligand LA comprises a structure of Formula Iis provided. In Formula I, if R2 and R3 are not joined to form a ring, then at least two of R1 to R6 are not H. Also in Formula I, if R1 and R2 are not H, then R1 and R2 are also not bonded to the first ligand LA. Formulations, OLEDs and consumer products containing the compound are also provided.

The application provides an internal gold peroxide complex, a preparation method and application thereof, and a structure formula of the internal gold peroxide complex is as a compound of formula (I) or a pharmaceutically acceptable salt thereof: The compound of formula (I) has photo-reactivity, under light conditions, the peroxide bond is cleaved, and a carbon free radical with biological activity is converted subsequently, can be combined with biological macromolecular proteins, DNA to destroy related biological functions, and plays an anticancer role; the compound can also contain a small molecule drug residue, and the released small molecule drug can enhance the antitumor activity in vivo.

This invention discloses a novel aggregation-induced luminescent substance targeted delivery method for a triple therapy combining chemotherapy, radiotherapy, and immunotherapy for tumors. This invention relates to the field of biotechnology, specifically to a novel aggregation-induced luminescent substance targeted delivery method for a triple therapy combining chemotherapy, radiotherapy, and immunotherapy for tumors. This invention provides a drug with inhibitory or anti-tumor activity against tumor cells. The active ingredient of the drug contains LNC@AIEgen, which is composed of inactivated cancer cells and Complex 1 loaded onto the inactivated cancer cells. The nanoplatform LNC@AIEgen designed in this invention is used for synergistic chemotherapy-radioimmunotherapy. This system fully utilizes the advantages of the delivery carrier, enhancing the anti-tumor therapeutic effect and acting as an anti-cancer vaccine. This simple yet effective strategy enables large-scale clinical treatment of cancer and contributes to personalized medicine.

The present invention relates to a process for the preparation of optically pure (+) or (-) enantiomers of iminium salts having formula (I), the process comprising the steps of: a) a reduction step of an iminium salt having formula (II), said salt being in the form of a racemic mixture, to give a compound having formula (III), also in the form of a racemic mixture; b) a chiral HPLC separation step of the compound of formula (III) in the form of a racemic mixture to obtain optically pure (+) or (-) enantiomer compounds having formula (IV); c) oxidation of a compound of formula (IV) to obtain a compound of formula (I); The present invention relates to a method comprising the steps of: JPEG2024533172000104.jpg95128

The application belongs to the technical field of biological medicine, and particularly relates to an N-heterocyclic carbene-gold (I)-phenyl alkyne complex and antibacterial application thereof. The N-heterocyclic carbene-gold (I)-phenyl alkyne complex has good bacteriostatic activity, and the minimum inhibitory concentration (MIC) is less than 5 muM. Meanwhile, it is found that the N-heterocyclic carbene-gold (I)-phenyl alkyne complex can enter cells, inhibit the growth and reproduction of intracellular bacteria by using the acidic environment in cells, and the cytotoxicity is significantly reduced compared with existing drugs, and has good application prospect.

Copper, silver and gold fluorinated alkoxide complexes such as complexes having a structure represented by the general formula (I) are described:, and multimers thereof and / or crystalline forms thereof as well as uses thereof, such as in processes to prepare materials, films and / or structures comprising copper, silver or gold using, processes including atomic layer deposition and chemical vapor deposition processes.

The invention provides a polyfluorinated aryl group complex as well as a preparation method and application thereof. The structural general formula of the polyfluorinated aryl group complex obtained by the method is shown in the specification. The polyfluorinated aryl group complex realizes unification of structural diversity, high selectivity and synthesis efficiency through heteronuclear bimetallic synergistic activation; and the compound also shows excellent biological functions and also has an anti-tumor proliferation effect. The polyfluorinated aryl group structure provides a rich molecular skeleton for drug design, also lays a foundation for biological activity optimization through accurate ligand electrical regulation and control, has the characteristics of academic innovation and industrial practicability, and has wide application prospects in the fields of medicines, materials and the like.

Synthesis and characterization of Au(II) dimeric complexes with pyridine dipyrrolinone (H2PyDP) ligands. Unique stability of these Au(II) dimers is disclosed when tested against thiol-containing reductants and other biomolecules. In addition, these complexes present antiproliferative activity at sub-micromolar levels in ovarian carcinoma cells, including cisplatin-resistant cells.

The present invention relates to a carbazole metal complex, a preparation method thereof, and an application thereof in the preparation of a drug for resisting the novel coronavirus. The carbazole metal complex is selected from one of the structures shown in Formula I, Formula II, or Formula III: 1 、R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 、R 12 、R 13 、R 14 Each is independently selected from -H, -OH, -COOH, -SH, -NH2, -NO2, -Cl, C1-C5 alkoxy or C1-C5 alkyl; M is selected from any one of Mn, Ru, Rh, Ir or Au; X is selected from any one or more of -F, -Cl, -Br, -OTf, -HCOO, -AcO, -BF4, acac, and CO. The various carbazole metal complexes provided by the present invention can achieve inhibition of 3CLPro at relatively low concentrations.