Core-shell structured gold cluster-carbon dot nano-particles as well as preparation method and application thereof

A technology of nanoparticles and carbon dots, applied in the field of nanomaterials, can solve the problems of single component of fluorescent carbon dots and complicated process, and achieve the effects of high yield, not easy to agglomerate, and good dispersibility.

Active Publication Date: 2016-08-24
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] CN 103981531A discloses a method for preparing fluorescent carbon dots. The method includes pretreatment and liquid-phase plasma discharge steps. Although it successfully prepares fluorescent carbon dots, the composition of fluorescent carbon dots prepared by this method is single, and its preparation Liquid phase plasma discharge is required in the process, and the process is relatively complicated

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  • Core-shell structured gold cluster-carbon dot nano-particles as well as preparation method and application thereof
  • Core-shell structured gold cluster-carbon dot nano-particles as well as preparation method and application thereof
  • Core-shell structured gold cluster-carbon dot nano-particles as well as preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0051] In this example, gold cluster@carbon dot core-shell nanoparticles are prepared by the following method, which specifically includes the following steps (the schematic diagram of the preparation method is as follows figure 1 shown):

[0052] (1) Mix polyene polyamine and citric acid in a mass ratio of 1:1, react at 170° C. for 2 hours to obtain a carbon dot solution, purify the synthesized carbon dots by dialysis, and obtain a carbon dot solution with a concentration of 12 mg / mL;

[0053] (2) Take 1mL of the carbon dot solution obtained in step (1), add 1mL of 10mM chloroauric acid solution, and after 10min, under stirring at a stirring speed of 1000rpm, add 1mL solution containing 12mg NaOH and 2mg NaBH dropwise. 4 The ice water solution was stirred and reacted at 25°C for 4h. After the reaction, the reaction product was centrifuged at 5000rpm with an ultrafiltration tube with a molecular weight cut-off of 10kDa, and the gold cluster-carbon dot nanoparticles were obtain...

Embodiment 2

[0058] In this example, gold cluster@carbon dot core-shell nanoparticles are prepared by the following method, which specifically includes the following steps (the schematic diagram of the preparation method is as follows figure 1 shown):

[0059] (1) Mix polyene polyamine and citric acid in a mass ratio of 5:1, react at 190° C. for 1 h to obtain a carbon dot solution, purify the synthesized carbon dots by dialysis, and obtain a carbon dot solution with a concentration of 30 mg / mL;

[0060] (2) Take 1mL of the carbon dot solution obtained in step (1), add 5mM chloroauric acid solution 5mL, after 5min, under stirring at a stirring speed of 5000rpm, add 1mL solution containing 8mg NaOH and 2mg NaBH dropwise. 4 The ice water solution was stirred and reacted at 20°C for 4h. After the reaction, the reaction product was centrifuged at 5000rpm with an ultrafiltration tube with a molecular weight cut-off of 10kDa, and washed several times with three times of water to obtain the gold c...

Embodiment 3

[0063] In this example, gold cluster@carbon dot core-shell nanoparticles are prepared by the following method, which specifically includes the following steps (the schematic diagram of the preparation method is as follows figure 1 shown):

[0064] (1) Mix polyene polyamine and citric acid at a mass ratio of 15:1, react at 130° C. for 8 hours to obtain a carbon dot solution, purify the synthesized carbon dots by dialysis, and obtain a carbon dot solution with a concentration of 1 mg / mL;

[0065] (2) Take 1mL of the carbon dot solution obtained in step (1), add 1mL of 15mM chloroauric acid solution, and after 15min, under stirring at a stirring speed of 5000rpm, add 1mL solution containing 4mg NaOH and 2mg NaBH dropwise. 4 The ice solution was stirred and reacted at 30°C for 2 hours. After the reaction, the reaction product was centrifuged at 5000rpm with an ultrafiltration tube with a molecular weight cut-off of 10kDa, and washed several times with three times of water to obtai...

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Abstract

The invention provides core-shell structured gold cluster-carbon dot nano-particles as well as a preparation method and application thereof. According to the gold cluster-carbon dot nano-particles, carbon dots are taken as a template, a nano gold cluster exists inside the template, the nano gold cluster and the carbon dots are connected by virtue of Au-N coordinate bonds, and the particle size of the gold cluster-carbon dot nano-particles is 3-5nm. The preparation method of the gold cluster-carbon dot nano-particles comprises the following steps: by taking carbon dots synthesized from polyethylene-polyamine and citric acid as a template, adding chloroauric acid, enabling the components to react in the presence of a reducing agent, so as to obtain the gold cluster-carbon dot nano-particles. The gold cluster-carbon dot nano-particles provided by the invention are uniform in particle size and good in dispersity, the nano gold cluster and the carbon dots are connected by virtue of the Au-N coordinate bonds, and the gold cluster is kept stable and is difficult to aggregate. The gold cluster-carbon dot nano-particles provided by the invention can be applied to intracellular oxidative stress amplification for tumor treatment.

Description

technical field [0001] The invention belongs to the field of nanomaterials and relates to a gold cluster-carbon dot nanoparticle and its preparation method and application, in particular to an ultra-small gold cluster-carbon dot nanoparticle with a core-shell structure and its preparation method and application. Background technique [0002] Tumor cells have high reactive oxygen species (Reactive oxygen species, ROS) levels, and are more sensitive to ROS than normal cells. But at the same time, tumor cells have high oxidative stress, which is typically characterized by up-regulation of reduced glutathione (GSH). GSH is the most important and abundant small-molecule antioxidant in cells. GSH provides anti-oxidative damage through its sulfhydryl group and inhibits tumor cell apoptosis. High concentrations of ROS can promote tumor cell division and proliferation, and increase tumor genome instability. sex and induce the occurrence and development of tumors. The balance betwee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y40/00B82Y30/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/07B22F1/065B22F1/054
Inventor 梁兴杰宫宁强马晓溦
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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