A kind of method for preparing glycolic acid compound

A technology of glycolic acid and compounds, applied in the field of preparation of glycolic acid compounds, can solve the problems of high cost of glycolic acid, high safety requirements, harsh reaction conditions, etc., achieve non-corrosive separation and reuse, and easy separation and reuse , the effect of mild reaction conditions

Active Publication Date: 2020-09-04
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Description
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AI Technical Summary

Problems solved by technology

This method not only has a long process flow and low yield, but also has defects such as small scale, serious equipment corrosion and environmental pollution, which makes the cost of producing glycolic acid relatively high, thus inhibiting the widespread use of glycolic acid to a certain extent
Although the later development of formaldehyde carbonylation and cyanidation greatly reduced the cost of producing glycolic acid, the former had harsh reaction conditions, required high temperature and high pressure, and had high requirements on equipment, while the latter used highly toxic cyanide, which was harmful to production. High security requirements in operation

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  • A kind of method for preparing glycolic acid compound

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[0017] In the method for preparing glycolic acid compounds provided by the present invention, the method uses 1,3-dihydroxyacetone as a reaction raw material, in the presence of a composite catalyst and an oxidizing agent, in a reaction medium, at a reaction temperature of 0-100°C Under the condition of catalytic reaction in the reactor for 2-48 hours, so as to obtain the glycolic acid compound.

[0018] In the present invention, the term "composite catalyst" refers to a catalyst composed of two or more metal oxides, or at least one metal oxide and at least another metal element, or at least one metal element and activated carbon. into a catalyst. Preferably, the composite catalyst used is composed of oxides of at least two selected from the following metals, or is composed of oxides of at least one of the following metals and at least another metal element, or is selected from At least one of the following metal elements and activated carbon composition: aluminum, bismuth, z...

Embodiment 1

[0029] Weigh 2.2 mg (0.013 mmol) of commercially available copper chloride dihydrate and add it to 4 mL of acetone, and stir magnetically in a 50 mL round bottom flask at room temperature. After the dissolution is complete, add such as 400mg γ-Al under stirring 2 o 3As a carrier, stirring was continued at room temperature for 24 h to obtain a solid powder. Calcined in a muffle furnace at 450 °C for 4 hours, the catalyst was obtained as a gray powder, which was analyzed by XRD, XPS, TEM and EXAFS (pattern not shown), indicating that the catalyst was Cu / Al 2 o 3 Complex, denoted as catalyst A.

Embodiment 2

[0031] Weigh 3.1 mg (0.013 mmol) of commercially available copper nitrate trihydrate and add it to 4 mL of acetone, and stir magnetically in a 50 mL round bottom flask at room temperature. After the dissolution is complete, add such as 400mg Al under stirring 2 o 3 As a carrier, stirring was continued at room temperature for 24 h to obtain a solid powder. Calcined in a muffle furnace at 450 °C for 4 hours, the catalyst was obtained as a gray powder, which was analyzed by XRD, XPS, TEM and EXAFS (pattern not shown), indicating that the catalyst was Cu / Al 2 o 3 The complex is denoted as Catalyst B.

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Abstract

The invention discloses a method for preparing a glycolic acid compound from 1, 3-dihydroxyacetone. According to the method, 1, 3-dihydroxyacetone as a reaction raw material undergoes a reaction at 0-100 DEG C in a reaction medium in the presence of a composite catalyst and an oxidant for 2-48h to produce the glycolic acid compound. The method is simple and is used under mild reaction conditions.The method can acquire a desired product in low cost and high yield so that the catalyst has high catalytic activity, can be separated from the reaction system and reused, and is environmentally friendly. Compared with the existing petroleum-based small molecule feedstock conversion method, the method provided by the invention promotes use of a biodiesel by-product 1, 3-dihydroxyacetone and is a potential, eco-friendly, efficient and economical glycolic acid production method.

Description

technical field [0001] The invention relates to a method for preparing glycolic acid compounds, in particular to a method for preparing glycolic acid compounds by using 1,3-dihydroxyacetone as a raw material and undergoing selective oxidation and cleavage of C-C bonds. Background technique [0002] Glycolic acid, also known as glycolic acid, glycolic acid, chemical formula HOCH 2 COOH, the simplest aliphatic hydroxy acid, has a wide range of uses in the fields of chemical engineering, cleaning, medicine and degradable materials. For example, the glycolic acid molecule has both a hydroxyl group and a carboxyl group, so it has the chemical properties of alcohol and carboxylic acid at the same time, and can be used to produce organic synthesis platform compounds such as ethylene glycol. It is an important organic synthesis raw material and intermediate; glycolic acid is a chemical An important component of the cleaning agent, 2% glycolic acid and 1% formic acid mixed acid is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/285C07C59/06B01J23/06B01J23/10B01J23/44B01J23/46B01J23/72B01J23/745B01J23/75B01J23/755B01J23/80
CPCB01J23/06B01J23/10B01J23/44B01J23/462B01J23/72B01J23/745B01J23/75B01J23/755B01J23/78B01J23/80C07C51/285C07C59/06
Inventor 石峰代兴超黄永吉
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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