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Preparation method of water phase CdTe/CdSe core-shell quantum dots for rapid fingerprint appearance

A technology of core-shell quantum dots and fingerprints, which is applied in the field of nanomaterial preparation technology and biological analysis and detection, can solve the problems of affecting the fluorescence intensity of CdTe/CdSe quantum dots, poor biocompatibility, and poor biological applicability, so as to reduce surface defects, Effect of short reaction time and low background adsorption

Inactive Publication Date: 2014-06-04
BEIJING UNIV OF CHEM TECH
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Zeng Qinghui and others published related patents on the preparation of CdTe / CdS core-shell quantum dots in the organic phase. The preparation conditions are harsh, the toxicity is high, the cost is high, and the biocompatibility is poor.
In 2007, Yan Xiuping and others used NaHSe as the Se precursor to prepare near-infrared fluorescent CdTe / CdSe core-shell quantum dots on the surface of CdTe by layer-by-layer assembly. The emission wavelength is at 650-800nm, and NaHSe is easily absorbed by O 2 Oxidation, not easy to store, and multi-layer coating will affect the fluorescence intensity of CdTe / CdSe quantum dots, poor biological applicability
At present, there is no domestic patent on CdTe / CdSe core-shell quantum dots used in fingerprint display

Method used

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  • Preparation method of water phase CdTe/CdSe core-shell quantum dots for rapid fingerprint appearance
  • Preparation method of water phase CdTe/CdSe core-shell quantum dots for rapid fingerprint appearance
  • Preparation method of water phase CdTe/CdSe core-shell quantum dots for rapid fingerprint appearance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Fixed condition: [Cd 2+ :TGA:Te=1:3:0.1], pH=8, [Te:Se=1:0.4]

[0030] (1). Preparation of cadmium precursor solution

[0031] Take 0.46g CdCl 2 2.5H 2 O was dissolved in 240ml deionized water, placed in a 500ml three-neck round bottom flask, airtight, and N 2 Stir for 15min, add dropwise 0.01ml mercaptoacetic acid [Cd 2+ :TGA=1:3] was added to a three-neck round bottom flask, and then adjusted to pH=8 with 2M NaOH to obtain [Cd-TGA] 2+ Colorless and transparent solution.

[0032] (2). Preparation of tellurium source and selenium source solution:

[0033] Preparation of NaHTe: Weigh 0.12g NaBH 4 Put it in a ground reaction bottle, add 2ml of deionized water to dissolve, and use N 2 Purge the reaction flask for 5 min. Then weigh 0.06g Te powder [NaBH 4 :Te=3:1] Put it into the reaction bottle, quickly cover the bottle stopper, put it in a 60~80°C water bath for 10~20min until the solution is colorless and transparent, and NaHTe is obtained;

[0034] Na 2 SeSO...

Embodiment 2

[0042] Varying different Te:Se ratios

[0043] [Cd 2+ :TGA:Te=1:3:0.1], pH=8, [Te:Se=1:3]

[0044] (1). The preparation of the cadmium precursor solution is the same as in Example 1 (1)

[0045] (2). The preparation of tellurium source and selenium source solution is the same as in Example 1 (2).

[0046] (3). Aqueous phase synthesis CdTe solution is the same as embodiment 1 (3)

[0047] (4). Aqueous phase synthesis of CdTe / CdSe with core-shell structure:

[0048] Get the CdTe solution prepared by 100ml step (3) and place in the three-necked reaction flask, then get the NaTe prepared by 7.5ml step (2) 2 SeSO 3 [Te:Se=1:3], sealed through N 2 , heated to reflux for 0.5h to obtain a CdTe / CdSe quantum dot solution with a core-shell structure.

[0049] (5). The fingerprint display steps are the same as in Example 1 (5), the fingerprint is displayed and the color is red.

Embodiment 3

[0051] Varying different pH values ​​and Te:Se ratios

[0052] [Cd 2+ :TGA:Te=1:3:0.1], pH=11, [Te:Se=1:0.4]

[0053] (1). Preparation of cadmium precursor solution

[0054] Take 0.46g CdCl 2 2.5H 2 O was dissolved in 240ml deionized water, placed in a 500ml three-neck round bottom flask, airtight, and N 2 Stir for 15min, add dropwise 0.01ml mercaptoacetic acid [Cd 2+ :TGA=1:3] was added to a three-neck round bottom flask, and then adjusted to pH=11 with 2M NaOH to obtain [Cd-TGA] 2+ Colorless and transparent solution.

[0055] (2). The preparation of tellurium source and selenium source solution is the same as in Example 1 (2).

[0056] (3). Aqueous phase synthesis CdTe solution is the same as embodiment 1 (3)

[0057] (4). Aqueous phase synthesis of CdTe / CdSe with core-shell structure:

[0058] The CdTe solution that gets 100ml step (3) preparation is placed in three-necked reaction flask, then gets the Na of 1ml step (2) preparation 2 SeSO 3 [Te:Se=1:0.4], sealed...

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Abstract

The invention discloses a preparation method of water phase CdTe / CdSe core-shell quantum dots for rapid fingerprint appearance, and belongs to the field of biomarkers. The method comprises the following steps: mixing a certain solubility of cadmium salt and a mercapto compound, adjusting pH to be 8-11 with NaOH to obtain a stable cadmium salt complex; dissolving Te powder and NaBH4 in deionized water, blowing with N2 to remove O2, heating in water bath at about 90 DEG C until no color to obtain a Te precursor; heating Se powder and a Na2SO3 water solution for reflux reaction until Se is completely reacted to obtain a Se precursor; adding the Te precursor into the cadmium salt complex under the N2 protection, heating for reflux to obtain CdTe quantum dots; adding a certain amount of the Se precursor to the CdTe quantum dots, heating for reflux to obtain the CdTe / CdSe core-shell quantum dots. The invention provides a simple and rapid preparation method of water soluble phase fluorescent core-shell quantum dots, and the preparation method has good biocompatibility, and can be used for appearance.

Description

technical field [0001] The invention relates to a preparation method of water-soluble fluorescent core-shell quantum dots and its application in fingerprint display, belonging to the fields of nanometer material preparation technology and biological analysis and detection technology. Background technique [0002] Quantum dots are a class of nanocrystals between individual molecules and bulk materials, mainly composed of II-VI and III-V group elements. Due to the surface effect, quantum size effect, and macroscopic quantum tunneling effect, it has excellent optical properties different from bulk materials. Such as: wide excitation spectrum, narrow emission spectrum, not easy to be decomposed and bleached by light, tunable fluorescence emission wavelength and other fluorescent characteristics, can be applied to the fields of fluorescent labeling, drug molecule tracer, trace analysis, etc., in molecular biology It has great application prospects in researches such as biology, ...

Claims

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Application Information

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IPC IPC(8): C09K11/88C09K11/02A61B5/117
Inventor 刘建军李洪雨左胜利
Owner BEIJING UNIV OF CHEM TECH
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