56 results about "Diazonium Compounds" patented technology

The invention belongs to the field of organic synthesis, and particularly relates to an efficient method for preparing ethyl chrysanthemate by using a Beta / CuCl nano molecular sieve catalyst. Glycine ethyl ester hydrochloride and sodium nitrite react in a heptane solvent to generate ethyl diazoacetate, and then ethyl diazoacetate reacts with octa-carbene to generate ethyl chrysanthemumate. The catalyst provides an acidic environment and active sites, promotes generation of diazo compounds, controls reactant diffusion through a pore channel structure, and improves the reaction rate and selectivity. The catalyst stabilizes the carbene intermediate and reduces the reaction temperature. The catalyst can be recycled, and environmental pollution and cost are reduced. The yield of the ethyl chrysanthemate exceeds 98%, the yield and quality are improved, and a new scheme is provided for the sanitary insecticide and pharmaceutical industry.

The present disclosure relates to aryl diazonium compounds and methods of cleaving DNA using the diazonium compounds as described herein. Further, the present disclosure relates to said aryl diazonium compounds conjugated to additional compounds as described herein.

The invention discloses a synthesis method of a glutaric acid ester compound, which comprises the following steps: reacting a propionate compound as shown in a formula 1 with a diazo compound as shown in a formula 2 in a solvent in a nitrogen atmosphere in the presence of a reducing agent under the illumination condition of visible light, and after the reaction is completed, separating out the glutaric acid ester compound, thereby obtaining the glutaric acid ester compound. And separating and purifying the reaction mixture to obtain the glutaric acid ester compound as shown in the formula 3. The propionate compound and the diazo compound are used as reaction substrates, the compound can be generated through reaction under mild conditions, the yield of the target product is improved, operation is easy and convenient, the reaction conditions are mild, the price of raw materials and solvents used in the whole process is low, and cost control is facilitated.

To provide a dry film laminate, a screen mask, and a method for manufacturing the screen mask which are capable of improving handleability.SOLUTION: The dry film laminate according to one embodiment includes a base film member, a cover emulsion layer laminated on one side of the base film, a base emulsion layer laminated on one side of the cover emulsion layer, and a cover film member laminated on one side of the base emulsion layer. The cover emulsion layer is composed of an emulsion containing at least polyvinyl alcohol, a diazonium compound, an ultraviolet curable resin, a photoinitiator and a silicone compound. The base emulsion layer is composed of an emulsion containing at least polyvinyl alcohol, a diazonium compound, an ultraviolet curable resin and a photoinitiator.SELECTED DRAWING: Figure 2

The present invention provides diazo compounds having anti-trypanosomal activity, with less or no side-effects. The diazo compounds are structural analogue of quinapyramine and possess characteristics necessary for the targeted pharmacologic action of anti trypanosomosis, with reduced cytotoxicity. The compounds were found to have less cytotoxicity, and identical or better anti- parasitemia effect as compared to conventional quinapyramine sulfate.

The present invention relates to sulfur ylide diazo compounds, their synthesis and their use for the transfer of a carbon atom or a CN2 group into an organic substrate comprising a pi electron system, in particular for C(sp3)-atom transfer to create carbon spiro centers. The invention further relates to related processes and the compounds thus obtained.

A method for producing a film of functionalized carbon nanostructures includes providing an electrode including a film of carbon nanostructures attached to a support, subjecting the electrode to an electrografting process in a bath containing water and at least one diazonium compound, conducting the electrografting process using potential pulses, wherein each potential pulse consists of an ON-time, wherein potential is applied for 0.01-0.1 s and an OFF-time, wherein zero potential is applied for 0.01-0.1 s, to form anchoring sites on the surfaces of the carbon nanostructures. Further is disclosed a film of functionalized carbon nanostructures. Further the use of the film or the method for forming a sensor, a filter, an electron stopping window, and / or a pellicle is explained.

The invention discloses a flavone derivative as well as a microwave preparation method and application thereof, and belongs to the technical field of medicinal chemistry. Comprising the following steps: S1, carrying out diazotization transfer reaction on a 1-phenyl-2-acetone compound to prepare an alpha-diazocarbonyl compound; and S2, heating the alpha-diazocarbonyl compound and 3-hydroxyflavone in microwaves to react to prepare the flavone derivative. The scheme provided by the invention is suitable for realizing Wolff rearrangement reaction of alpha-diazo compounds and alcohol compounds in microwaves, does not need to use the traditional kettle reaction, catalyst and excessive substrate, and has the advantages of simple operation, rapid reaction, few byproducts, high yield, short time and wide substrate application range; and the prepared flavonoid ester compound has an excellent anti-cancer effect.

The present disclosure relates to the field of dye chemical industry, and in particular to a method for preparing azo disperse dyes. The method provided by the present disclosure comprises the following steps: subjecting an aromatic compound containing a nitro group and a primary amine to a diazo reaction with a nitrous acid compound to obtain a diazo compound intermediate product; and subjecting the diazo compound intermediate product to a coupling reaction with a compound containing a tertiary amine under the action of a phase transfer catalyst to obtain an azo disperse dye.

The present invention relates to the technical field of organic synthesis, and in particular to a 2-cyanoindole-substituted gem-difluoroolefin compound and its preparation method and application. The compound preparation method comprises: using trifluoromethylindolemethanol compounds and trimethylsilyl cyanide as raw materials, and heating the reaction in a solvent under the action of a Lewis acid catalyst and an inorganic base to obtain the 2-cyanoindole-substituted gem-difluoroolefin compound. The present invention provides a 2-cyanoindole-substituted gem-difluoroolefin compound and its preparation method. The method uses trifluoromethylindolemethanol compounds and trimethylsilyl cyanide, which are easily available, as raw materials, and does not require the use of explosive diazo compounds. It has the advantages of mild reaction conditions, simple operation, high yield, and a wide range of reaction substrates.

The present invention discloses a flavonoid derivative, its microwave preparation method and application, belonging to the technical field of pharmaceutical chemistry. It includes the following steps: S1. Prepare an α-diazo carbonyl compound from a 1-phenyl-2-propanone compound through a diazotization transfer reaction; S2. Heat and react the α-diazo carbonyl compound and 3-hydroxyflavone in a microwave to prepare a flavonoid derivative. The solution of the present invention is applicable to the Wolff rearrangement reaction of α-diazo compounds and alcohol compounds in a microwave, without the need to use traditional kettle reactions, catalysts and excessive substrates, and has the advantages of simple operation, rapid reaction, few by-products, high yield, less time and a wide range of substrate applicability. Moreover, the prepared flavonoid ester compound has excellent anti-cancer effects.

The invention relates to application of Nogo-B protein in preparation of a medicine serving as an anti-osteosarcoma target spot. The invention discloses an alpha-hydroxyl / alkoxy / amino-beta-amino derivative, a synthesis method thereof and application of Nogo-B protein serving as a new osteosarcoma target, an osteosarcoma diagnostic reagent and a small-molecule inhibitor 4v serving as an osteosarcoma targeting drug. A diazo compound, water / alcohol / amide and imine are used as raw materials, rhodium acetate is used as a catalyst, a product is obtained in an organic solvent through a one-step reaction with high selectivity and high yield, then the small-molecule inhibitor 4v is obtained through osteosarcoma cell surface screening, a new osteosarcoma target Nogo-B is proposed based on a proteomics analysis technology, and the new target Nogo-B is used for inhibiting osteosarcoma. The effects of inhibiting cell proliferation and migration and tumor growth can be achieved through experiments such as knockout of Nogo-B protein. The invention discloses a novel application of Nogo-B protein. The Nogo-B protein is used for preventing, relieving and treating osteosarcoma and osteosarcoma-related complications of individuals in need. Also disclosed are methods of diagnosing, treating, and monitoring osteosarcoma or methods of inhibiting osteosarcoma, and methods of screening for osteosarcoma inhibitors.

This invention provides a neutral-electron-reversed carbene, its preparation method, and its applications, belonging to the fields of organic chemistry and organic catalysis. The neutral-electron-reversed carbene described in this invention has the structure shown in formula (I). This invention synthesizes the neutral-electron-reversed carbene in one step by reacting a diazo compound as a precursor with a rhodium complex, followed by nitrogen removal and COD (1,5-cyclooctadiene) removal processes. The reaction conditions of this invention are simple, and the yield is good. Stable separation of neutral-electron-reversed carbene is achieved for the first time.

This invention belongs to the field of organic synthesis and relates to a [3+2] orthogonal cycloaddition method for the reaction of an active amino acid ester with a diazo compound and its application in synthetic chemistry. The method comprises: under inert gas protection and in the presence of a base and solvent, contacting the active amino acid ester with a diazo compound to undergo a [3+2] orthogonal cycloaddition reaction to obtain the 1,2,4-triazole compound represented by Formula I. The method of this invention uses readily available active amino acids and diazo compounds as starting materials, enabling the efficient and selective synthesis of highly functionalized, fully substituted 1,2,4-triazoles, and achieving a rapid and efficient orthogonal connection between two molecules linked to the diazo compound and the active ester.

The utility model relates to the technical field of diazo compounds, and discloses an automatic control continuous production device of diazo compounds, which comprises two fixing blocks, the two fixing blocks are arranged front and back, the lower sides of the two fixing blocks are fixedly connected with supporting legs, a reaction kettle body is rotatably connected between the two fixing blocks, and the reaction kettle body is connected with a reaction kettle body. A blocking cover is fixedly connected to the rear side of the reaction kettle body, an opening groove is formed in the outer surface of the reaction kettle body, an opening-closing door is arranged on the opening groove, a rotating shaft is rotationally connected between the opening-closing door and the opening groove, the opening-closing door and the opening groove are rotationally connected through the rotating shaft, the opening-closing door and the rotating shaft can be clamped together, and a handle is fixedly connected to the upper side of the opening-closing door. The stirring mechanism is arranged in the front side fixing block and the reaction kettle body, so that materials in the reaction kettle body can be uniformly stirred and reacted, the temperature in the reaction kettle body is relatively uniform, and the conditions of low yield and poor quality of produced diazonium substances are avoided.

A method for forming an inhibitor layer on a transition metal surface is provided. The method includes introducing diazo compounds to bind to atoms of the transition metal surface, dosing a monomer to initiate polymerization for building up the inhibitor layer, depositing material onto a growth area adjacent to the transition metal surface and etching the inhibitor layer following completion of the depositing of the material onto the growth area.

The invention belongs to the field of organic chemistry, and relates to a chiral spiro-oxoindole compound and a synthesis method thereof. The chiral spiro-oxoindole compound is a compound with a structure as shown in a formula (1), or an epoxide or a hydrogenation product thereof: # imgabs0 # in the formula (1), R1 is methyl or benzyl; r2 is at least one of hydrogen, alkyl of C1-C4, alkoxy of C1-C4 and halogen; r3 is phenyl, substituted phenyl, naphthyl or phenyl (C1-C4) alkyl, and preferably, the substituent group of the substituted phenyl is at least one of hydrogen, C1-C4 alkyl, C1-C4 alkoxy and halogen. A series of chiral spiro-oxoindole derivatives are efficiently constructed by using oxoindole ketene generated by a simple and easily available diazo compound under the illumination condition and alkenyl oxygen heterocyclic propane under the conditions of a metal catalyst and a chiral ligand, and a simple and efficient new method is provided for synthesizing bioactive molecules containing the skeleton.

The invention belongs to the field of organic synthesis, and relates to a [3 + 2] orthogonal cycloaddition method of amino acid active ester and a diazo compound and application of the [3 + 2] orthogonal cycloaddition method in synthetic chemistry. The method comprises the following steps: under the protection of inert gas, in the presence of alkali and a solvent, enabling amino acid active ester to be in contact with a diazo compound to carry out [3 + 2] orthogonal cycloaddition reaction, so as to obtain the 1, 2, 4-triazole compound as shown in the formula I. The invention further discloses a preparation method of the 1, 2, 4-triazole compound. According to the method, the amino acid active and diazo compounds which are simple and easy to obtain are used as starting raw materials, highly-functionalized fully-substituted 1, 2, 4-triazole can be efficiently synthesized in a high-selectivity mode, and rapid and efficient orthogonal connection of two molecules connected to diazo and active ester is achieved. # imgabs0 #

The invention discloses a method for synthesizing quinoxaline derivatives by catalyzing arylamine and a diazo compound through acidic functionalized ionic liquid, and belongs to the technical field of fine organic synthesis. A 2-aryl aniline compound and a diazo compound are placed in the presence of a solvent, an acid and an ionic liquid, subjected to a cascade reaction of wolf rearrangement, nucleophilic addition, oxidation and cyclization at 100-140 DEG C, cooled to the room temperature, extracted with ethyl acetate, dried with anhydrous sodium sulfate and then subjected to reduced pressure distillation to remove the solvent, a mixed crude product is obtained, and the 2-aryl aniline compound is obtained. And separating and purifying the mixture by adopting silica gel column chromatography to obtain the quinoxaline derivative. The method has the advantages that the catalyst is green and renewable, the operation is simple, the selectivity is high, the substrate range is wide, and the tolerance to functional groups is good, the diazo compound is rearranged into the phthalic acid by virtue of tandem wolf rearrangement, nucleophilic addition, oxidation and cyclization, and a new way is provided for synthesis of quinoxaline derivatives.

The invention discloses a method for preparing a five-membered azo compound through laughing gas mediation, which comprises the following steps: S1, reacting a gem-diborate compound as shown in a formula I with laughing gas in the presence of a solvent and an alkali reagent to obtain a diazo compound; and S2, adding an olefin compound as shown in a formula II into the reaction system containing the diazo compound for continuous reaction to obtain the five-membered azo compound as shown in a formula III. According to the preparation method, the laughing gas serves as a nitrogen source, the gem-diborate and the olefin which are low in price and easy to obtain serve as reaction raw materials, the known and series of novel five-membered azo compounds can be prepared through a one-pot method, the preparation method is simple, reaction conditions are mild, the reaction yield is high, and the preparation method is suitable for industrial production of the five-membered azo compounds. Besides, the five-membered azo compound prepared by the method can be further converted to prepare a cyclopropane compound and a 1, 3-diamine compound, and has important application value in the fields of biological medicines, pesticides and the like.

A method for producing a functionalized carbon nanostructure film is disclosed. The method comprises:-providing an electrode comprising a carbon nanostructured membrane attached to a support,-subjecting the electrode to an electrical grafting process in a bath containing water and at least one diazo compound,-subjecting the electrode to an electrical grafting process using electrical potential pulses wherein each electrical potential pulse consists of an on-time during which an electrical potential is applied from 0.01 to 0.1 s and an off-time during which an electrical potential is applied from 0.01 to 0.1 s, and-subjecting the electrode to a process for removing the diazo compound from the electrode. And in the turn-off time, applying a zero potential for 0.01-0.1 s to form anchoring points on the surface of the carbon nanostructure. Further, the present invention discloses a functionalized carbon nanostructure membrane. Further, the use of the film for forming a sensor, a filter, an electron blocking window and / or a photomask protective film or the use of a method for forming a sensor, a filter, an electron blocking window and / or a photomask protective film is disclosed.

The invention belongs to the technical field of biochemistry, and particularly relates to a method for synthesizing a flavanone compound through nano-enzyme catalyzed carbene transfer and intramolecular ring closing. The monatomic nano-enzyme is applied to catalysis of non-natural reaction, and the monatomic nano-enzyme is found to have the capability of mediating carbene transfer. 24 flavanone compounds are successfully synthesized by catalyzing a substrate diazo compound through the screened nano-enzyme and organic solvent, and the yield for a plurality of substrates of the type is high. The method disclosed by the invention is simple to operate, mild in condition, low in catalyst cost, high in stability and long in service life, a nano-enzyme catalysis method is good in substrate universality, a mild and direct method is provided for synthesizing the flavanone compound, and the method has a very good industrial application prospect.

The invention discloses a method for preparing a functional electrode through surface in-situ carbene polymerization, which is characterized in that carbene polymerization is initiated on the surface of a metal electrode in situ through a diazo compound to form a uniform polymer film covalently bonded with the surface, so that the stability and electro-catalytic performance of the electrode are remarkably improved. The method is simple and convenient to operate, is suitable for various metal electrodes and electrolysis devices, and has a wide application prospect.

The application discloses a synthetic method for constructing N-B bond-containing pyrazole derivatives, and the method is characterized in that, under light conditions, an iridium metal complex is used as a photosensitizer, and an alkenyl diazo compound 1 is reacted with an azaheterocyclic carbene borane compound 2 in a solvent. In the reaction process, the azaheterocyclic carbene borane compound 2 generates an azaheterocyclic carbene boron radical cation through a single electron transfer process under the action of visible light and the photosensitizer, and the azaheterocyclic carbene boron radical cation then completes an addition-cyclization reaction on the alkenyl diazo compound 1. The method is driven by visible light as a green energy source, and the reaction is carried out in an air atmosphere, has a short reaction time and high efficiency, and is easy to operate.

The present invention discloses a method for synthesizing 1,4-dicarbonyl quinoxalinone derivatives. Under photoredox catalysis, diazo compound B generates a radical precursor through a proton-coupled electron transfer (PCET) process to add to quinoxalin-2(1H)-one compound A. Subsequently, compound G is obtained through the isomerization of enamine and imine. The alkyl radical adds to the imine again, and finally, a 1,4-dicarbonyl quinoxalinone derivative is obtained through single electron transfer and deprotonation. This method uses visible light as a green energy source for driving, methanol and water as reaction solvents, and has mild reaction conditions and is easy to operate.

A method of preparing a substrate (1), which method comprises the following steps: (a)providing a substrate (1) with a cleaned surface (2), (b) pre-treating the cleaned surface (2) of the substrate (1) with aryl diazonium compounds dissolved in a liquid solution, (c)activating the pre-treated surface of the substrate, and (d) metallizing the activated surface of the substrate by exposing the surface of the substrate to a metal salt to provide a metal plating (3) on the substrate.The pre-treating of the cleaned surface of the substrate is performed by exposing the cleaned surface to a liquid in which the aryl diazonium compounds are dissolved. Furthermore, providing a corresponding product comprising a substrate (1) as prepared by the method.

To detect an aromatic organochlorine compound rapidly and inexpensively.SOLUTION: A method for detecting an aromatic organochlorine compound, comprising a reduction step of obtaining a first liquid by bringing an aqueous solvent into contact with a mixed liquid of a hydrophobic liquid sample and a reducing agent, and a first color development step of bringing the first liquid into contact with a first color-developing agent containing a chromogenic substrate that reacts with an aromatic organic compound having a hydroxyl group or with a second color-developing agent containing a diazonium compound.SELECTED DRAWING: Figure 1

A micro-nano structure-based super-hydrophobic fabric and a preparation method therefor are disclosed. A brand-new method of combining carbene polymerization covalent grafting with solid surface self-assembly is used for the first time to prepare a modified fabric having super-hydrophobic and self-cleaning functions, by taking an aliphatic diazo compound and an aromatic diazo compound as monomers for carbene copolymerization to graft a fluorine-containing and phenyl-containing block copolymer having a single-carbon repeating unit onto the surface of a fabric by means of a covalent bond. A carbene polymer is crystallized under the induction of the surface of a fiber to drive self-assembly to construct a hierarchical roughened structure having a micro-nano composite structure on the surface of the fabric, and a secondary structure is a nano-scale mastoid-shaped structure imitating a lotus leaf surface.

The invention belongs to the technical field of biochemistry, and particularly relates to a method for catalytically synthesizing a chiral flavanone compound by a biological enzyme. The invention develops a method for producing chiral flavanone through intramolecular cyclization by taking a diazo compound as a substrate and carrying out carbene transfer and hydrocarbon activation by using a heme-containing biological enzyme. The yield of the chiral flavanone compound generated after the diazo substrate is catalyzed by the screened enzyme to carry out intramolecular ring closing reaction is high, and the catalytic reaction carried out by utilizing the enzyme is mild in condition, simple to operate and green and environment-friendly. The chiral flavanone compound prepared by using the method disclosed by the invention is good in substrate universality, has medium-high yield and selectivity, is low in cost, and has very good potential in the application of synthesis and modification of some drug intermediates.