9 results about "Diazonium Compounds" patented technology

The present invention provides diazo compounds having anti-trypanosomal activity, with less or no side-effects. The diazo compounds are structural analogue of quinapyramine and possess characteristics necessary for the targeted pharmacologic action of anti trypanosomosis, with reduced cytotoxicity. The compounds were found to have less cytotoxicity, and identical or better anti- parasitemia effect as compared to conventional quinapyramine sulfate.

This invention provides a neutral-electron-reversed carbene, its preparation method, and its applications, belonging to the fields of organic chemistry and organic catalysis. The neutral-electron-reversed carbene described in this invention has the structure shown in formula (I). This invention synthesizes the neutral-electron-reversed carbene in one step by reacting a diazo compound as a precursor with a rhodium complex, followed by nitrogen removal and COD (1,5-cyclooctadiene) removal processes. The reaction conditions of this invention are simple, and the yield is good. Stable separation of neutral-electron-reversed carbene is achieved for the first time.

The invention belongs to the technical field of biochemistry, and particularly relates to a method for synthesizing a flavanone compound through nano-enzyme catalyzed carbene transfer and intramolecular ring closing. The monatomic nano-enzyme is applied to catalysis of non-natural reaction, and the monatomic nano-enzyme is found to have the capability of mediating carbene transfer. 24 flavanone compounds are successfully synthesized by catalyzing a substrate diazo compound through the screened nano-enzyme and organic solvent, and the yield for a plurality of substrates of the type is high. The method disclosed by the invention is simple to operate, mild in condition, low in catalyst cost, high in stability and long in service life, a nano-enzyme catalysis method is good in substrate universality, a mild and direct method is provided for synthesizing the flavanone compound, and the method has a very good industrial application prospect.

The invention belongs to the technical field of biochemistry, and particularly relates to a method for catalytically synthesizing a chiral flavanone compound by a biological enzyme. The invention develops a method for producing chiral flavanone through intramolecular cyclization by taking a diazo compound as a substrate and carrying out carbene transfer and hydrocarbon activation by using a heme-containing biological enzyme. The yield of the chiral flavanone compound generated after the diazo substrate is catalyzed by the screened enzyme to carry out intramolecular ring closing reaction is high, and the catalytic reaction carried out by utilizing the enzyme is mild in condition, simple to operate and green and environment-friendly. The chiral flavanone compound prepared by using the method disclosed by the invention is good in substrate universality, has medium-high yield and selectivity, is low in cost, and has very good potential in the application of synthesis and modification of some drug intermediates.

This invention provides a method for preparing α-BMIDA ester compounds. The method uses α-BMIDA propylene ester and potassium alkyl trifluoroborate as substrates, and generates α-BMIDA esters through intermolecular radical addition-protonation reaction under photocatalytic conditions. This achieves the goal of efficient and versatile synthesis of α-BMIDA esters with different functional groups. The use of α-BMIDA propylene ester as the core reaction unit effectively allows for reaction with various alkyl radicals from different sources or structures, enriching the variety of α-BMIDA esters. Furthermore, the method avoids the use of oxidants and diazo compounds. The yield of most synthesized α-BMIDA ester products is higher than 80%. It has the advantages of mild reaction conditions, simple steps, fast reaction rate, and high yield. The reactants used are readily available, and the catalyst is inexpensive, providing an economical and convenient solution and technical support for the large-scale preparation of α-BMIDA ester compounds.

The application discloses a method for preparing a five-membered azo compound mediated by laughing gas, and comprises the following steps: S1, reacting gem-boronate compounds shown in formula I with laughing gas in the presence of a solvent and a base reagent to obtain a diazo compound; S2, adding olefin compounds shown in formula II to the reaction system containing the diazo compound to continue the reaction to obtain five-membered azo compounds shown in formula III. The preparation method uses laughing gas as a nitrogen source, and cheap and easily obtained gem-boronate and olefin as reaction raw materials, so that known and novel five-membered azo compounds can be prepared by one-pot method. The preparation method is simple, the reaction condition is mild, and the reaction yield is high, and the method is suitable for industrialized production of the five-membered azo compounds. In addition, the five-membered azo compounds prepared by the application can be used for further conversion to prepare cyclopropane compounds and 1,3-diamine compounds, and have important application value in the fields of biological medicines, pesticides and the like.

The application discloses an axially chiral phthalazine compound and a synthesis method and application thereof, and belongs to the technical field of pharmaceutical intermediates. The compound structure is shown in the following formula: or. The application takes a diazo compound as raw material, takes a chiral phosphorus catalyst as a catalyst, takes a Bronsted acid and an organic base as co-catalysts, takes silane as a reducing agent, takes an organic solvent as a solvent, takes 4A molecular sieve as an additive, and obtains the product through one-step reaction, column chromatography purification under a mild reaction temperature, has the advantages of high enantioselectivity and yield, and has the advantages of mild reaction condition, wide applicability of substrate range, simple operation and safety. The obtained axially chiral phthalazine compound has an antitumor effect, and is an important chemical, chemical and pharmaceutical intermediate.

This invention relates to a coloring photosensitive resin composition for forming partition walls, partition wall structures, and display devices. The coloring photosensitive resin composition for forming partition walls is characterized by comprising a colorant, an alkali-soluble resin, a photopolymerization initiator, and a solvent. The colorant comprises one or more compounds selected from the group consisting of perylene compounds and diazo compounds, and a black colorant. The solvent comprises a solvent with a viscosity of 2.0 cP or higher at room temperature. The aforementioned coloring photosensitive resin composition for forming partition walls can readily form partition walls with low specular reflectivity to light sources, thus improving visibility and providing a thicker thickness.