Method for synthesizing amino-substituted carbazole compound

Abstract

The invention discloses a method for synthesizing an amino-substituted carbazole compound, belonging to the technical field of organic synthesis. According to key points of the technical scheme, the method disclosed by the invention comprises the following steps: dissolving 2-phenyl-3-cyanoindole compounds or 2-(thiazole-2-yl)-3-cyanoindole compounds and diazo compounds in a solvent; adding catalysts and additives, reacting at the temperature of 100-140 DEG C so as to obtain 6-aminobenzo[a]carbazole compounds or 5-aminothieno[a]carbazole compounds. The method disclosed by the invention starts from simple and easily prepared raw materials, the amino-substituted carbazole compounds are directly obtained by virtue of a one-pot cascade reaction, the synthetic process is easy and convenient to operate, the conditions are mild, and the method is suitable for industrial production.

Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a synthesis method of amino-substituted carbazole compounds. Background technique

[0002] Amino-substituted carbazole is an important nitrogen-containing heterocyclic skeleton, which is commonly found in functional organic molecules such as pesticides, medicines, and fluorescent reagents. In addition, amino-substituted carbazole compounds are also intermediates for the synthesis of various antiviral and antitumor lead compounds. In view of its importance, people have successively developed some methods of synthesizing these compounds. Although most of the synthetic strategies in these literatures are relatively effective, there are still some problems to be solved, such as: the need to use expensive raw materials and catalysts, harsh reaction conditions, and the need for functional group protection and deprotection during the synthesis process. Therefore,...

Images