11results about How to "Simple reaction system" patented technology

This invention discloses a method for the selective synthesis of 4-amino-N-(hetero)arylsulfonamide compounds. Using bipyridine as a ligand and nickel as a catalyst, and inexpensive and readily available low-activity (hetero)aryl chlorides and 4-aminobenzenesulfonamides as substrates, 1,8-diazabicycloundec-7-ene and other organic bases are used, along with sodium iodide and other additives. The synthesis of various 4-amino-N-(hetero)arylsulfonamide compounds is achieved through a photo-driven nickel-catalyzed selective C-N coupling reaction of (hetero)aryl chlorides and 4-aminobenzenesulfonamides under an argon atmosphere. This invention features a simple reaction system, convenient operation, mild reaction conditions, and simple post-processing. It exhibits good selectivity for target compounds and high yields, avoiding the problems of complex catalytic systems and poor functional group compatibility caused by the use of traditional expensive metal catalysts and inorganic bases. Therefore, it has significant application value and market prospects.

This invention relates to the visible light-induced synthesis of α-aryl-β-difluoromethyl-substituted ketone compounds. The method utilizes a photocatalytic strategy to construct valuable α-aryl-β-difluoromethyl-substituted ketone compounds through radical-mediated difluoromethylation and migration of 1,2-aryl groups. The method and synthetic steps include: Step 1: Using 80W blue light as a visible light source, α,α-diphenylallyl alcohol (1a), difluoromethyl ylide (2), photocatalyst fac-Ir(ppy)3, sodium acetate, and methanol are added to a 10 mL reaction tube and placed in a nitrogen atmosphere; Step 2: Under visible light irradiation, the reaction is stopped when the starting material α,α-diphenylallyl alcohol (1a) is completely consumed; Step 3: After the reaction is complete, the solvent is removed by vacuum distillation. The crude product is purified by rapid column chromatography to obtain α-aryl-β-difluoromethyl-substituted ketone compounds (3a). This reaction has the advantages of mild conditions, simple operation, broad substrate compatibility, and good functional group tolerance.

The application discloses a metal single-atom molecular sieve composite catalyst and a preparation method and application thereof. The metal single-atom molecular sieve composite catalyst comprises a molecular sieve and an active component; the molecular sieve is ZSM-23 molecular sieve; and the active component is an Fe-N-C species. The metal single-atom molecular sieve composite catalyst provided by the application is applied to a reaction of methane low-temperature oxidation for preparing C1 liquid products, and can realize direct oxidation of methane for preparing C1 liquid products under low-temperature conditions below 80 DEG C, and has outstanding catalytic activity, selectivity and good stability.

The invention discloses a preparation method of a 2-substituted quinazoline derivative, which comprises the following step: heating and stirring three components, namely an ammonium salt, a benzyl alcohol compound and a 2, 1-benzisoxazole compound in an organic solvent to obtain the 2-substituted quinazoline derivative. According to the method, ammonium iodide which is low in price and easy to obtain is used as a nitrogen source and an oxidizing agent, benzyl alcohol is used as a carbon source, and efficient construction from a 2, 1-benzisoxazole skeleton to a 2-substituted quinazoline skeleton is achieved through a carbon-nitrogen diatom inserted ring expansion reaction under the mild conditions of no metal and no additive. The synthetic method developed by the invention has a good application prospect in the industrial fields of biological medicines, pesticides and the like, and is particularly suitable for efficiently preparing the quinazoline compound with biological activity under simple and convenient conditions. The synthetic method developed by the invention has a good application prospect in the industrial fields of biological medicines, pesticides and the like, and a theoretical basis is provided for commercialized application of the derivatives in the field of medicines.

This invention relates to a method for preparing a kilogram-scale water-soluble nitrogen-containing actinide element extractant, comprising the following steps: S1. Synthesizing amide hydrazone via nucleophilic addition reaction: Adding hydrazine hydrate or anhydrous hydrazine to a dimethyl nitrile solution, performing a nucleophilic addition reaction, and then separating the solid and liquid phases to obtain the amide hydrazone; S2. Synthesizing pyridine triazine derivative via condensation cyclization reaction: Dispersing or dissolving the ground amide hydrazone and diphenylethylene glycol in a solvent, performing a condensation cyclization reaction, and then separating the solid and liquid phases to obtain the pyridine triazine derivative; S3. Obtaining the extractant via substitution reaction: Adding a sulfonating agent to the pyridine triazine derivative, refluxing to perform a substitution reaction, and then slowly adding the reaction mixture dropwise to a phase inversion agent to precipitate the extractant. Compared with the prior art, the preparation method of this invention is simple and feasible, with a simple reaction system, high product yield, short production cycle, simple processing technology, low energy consumption, inexpensive and readily available raw materials, and easy to industrialize, showing broad application prospects in the field of high-level radioactive waste disposal.

The application belongs to the technical field of medicine, chemical industry and related chemistry, and discloses a preparation method of difluoromethyl arene compound based on palladium catalytic decarbonylation coupling. The method uses aryl boronic acid as a raw material, uses N, N-disubstituted difluoroacetamide compound as a difluoromethylation reagent, and prepares difluoromethyl arene compound under the catalysis of palladium, so that the green and efficient synthesis is realized. The method has the advantages of easy preparation and storage of the difluoromethylation reagent, high reaction selectivity, good functional group compatibility, wide substrate application range, environmental friendliness and the like. Since the difluoromethyl arene compound is an important functional molecular skeleton structure, the compound has very wide application in the fields of fine chemical industry and pharmacy, so that the application has great application value and social and economic benefits.

This application discloses a nonspecific peroxidase CsaUPO derived from *Cladorrhinum samala*, whose amino acid sequence is shown in SEQ ID NO:1. This enzyme efficiently catalyzes the 4,5β-epoxidation of testosterone to produce 4,5β-epoxidized testosterone, achieving a conversion rate of 98% and a separation yield of 90%, without producing hydroxylation byproducts, and exhibiting excellent regioselectivity. This application also discloses the gene encoding CsaUPO, the recombinant plasmid pPICZA-CsaUPO containing this gene, a recombinant Pichia pastoris engineered strain, and its application in steroid epoxidation. The nonspecific peroxidase CsaUPO disclosed in this application possesses advantages such as high catalytic efficiency, specific regioselectivity, a simple reaction system, and environmental friendliness, providing a new enzymatic resource for the site-directed epoxidation modification of steroid drugs.

The application belongs to the technical field of super-hydrophobic material preparation, and particularly relates to a simple preparation of super-hydrophobic silica nanowires and a method for constructing a super-hydrophobic coating. Alkyl chlorosilane and alkyl siloxane are used as structural reagents, and organic reagents with different water contents are used as solvents to initiate the hydrolysis and condensation of silane to prepare silica nanowires. The method is simple to operate, and the reaction conditions are mild, without the need to introduce acid or base catalysts. The prepared silica nanowires are sprayed onto the surface of a substrate to obtain a super-hydrophobic coating. The method is suitable for realizing low-cost, large-scale and rapid construction of super-hydrophobic coatings on various substrates, and has a wide application prospect.

The invention provides EB (Epstein-Barr) virus nucleic acid detection primers, a probe and a kit, according to a target sequence of an EB virus gene, the sequences of the primers and the probe in an asymmetric primer ERA detection system are designed and screened, and the ratio of upstream and downstream primers and an amplification reaction system are optimized, so that the EB virus nucleic acid sequence can be specifically identified, and the EB virus nucleic acid detection kit has the advantages of high specificity and high sensitivity. Non-specific binding with other irrelevant nucleic acids is reduced, so that the detection specificity is improved; meanwhile, efficient amplification of EB virus nucleic acid is realized, and the EB virus nucleic acid can be accurately detected even under the condition that the content of the virus nucleic acid is extremely low, so that the detection sensitivity and the amplification efficiency are improved.

The invention relates to the technical field of biological materials, in particular to a polydopamine coating as well as a preparation method and application thereof. According to the specific technical scheme, a dopamine solution and a hydrogen peroxide aqueous solution are mixed on the surface of a base material to be coated, and the polydopamine coating is generated. The prepared polydopamine coating can effectively improve the lower urinary symptoms such as pathological bladder mucous membrane barrier damage, erosion, bleeding, pain, frequent urination and urgent urination, mucous membrane repair is accelerated, and the life quality of a patient is improved. The technical scheme provided by the invention has a wide application prospect in the field of chemical cystitis treatment.

The application discloses a photochemical cobalt catalytic synthesis method of arylamine compounds, uses bipyridine as a ligand, uses a cobalt salt as a catalyst, uses cheap and abundant aryl bromide and amine compounds as reactants, adds an organic base, and realizes synthesis of arylamine compounds by promoting C-N coupling reaction of aryl bromide and amine compounds through cobalt catalysis in an argon atmosphere. The reaction system is simple, the operation is simple, the reaction condition is mild, the post-treatment is simple, the target compound is good in selectivity and high in yield, the use of traditional expensive metal catalysts and inorganic bases is avoided, problems such as complicated catalytic system reaction and poor functional group compatibility are avoided, and the method has good application value and market prospect.