6results about How to "Simple reaction system" patented technology

This invention discloses a method for the selective synthesis of 4-amino-N-(hetero)arylsulfonamide compounds. Using bipyridine as a ligand and nickel as a catalyst, and inexpensive and readily available low-activity (hetero)aryl chlorides and 4-aminobenzenesulfonamides as substrates, 1,8-diazabicycloundec-7-ene and other organic bases are used, along with sodium iodide and other additives. The synthesis of various 4-amino-N-(hetero)arylsulfonamide compounds is achieved through a photo-driven nickel-catalyzed selective C-N coupling reaction of (hetero)aryl chlorides and 4-aminobenzenesulfonamides under an argon atmosphere. This invention features a simple reaction system, convenient operation, mild reaction conditions, and simple post-processing. It exhibits good selectivity for target compounds and high yields, avoiding the problems of complex catalytic systems and poor functional group compatibility caused by the use of traditional expensive metal catalysts and inorganic bases. Therefore, it has significant application value and market prospects.

This invention relates to the visible light-induced synthesis of α-aryl-β-difluoromethyl-substituted ketone compounds. The method utilizes a photocatalytic strategy to construct valuable α-aryl-β-difluoromethyl-substituted ketone compounds through radical-mediated difluoromethylation and migration of 1,2-aryl groups. The method and synthetic steps include: Step 1: Using 80W blue light as a visible light source, α,α-diphenylallyl alcohol (1a), difluoromethyl ylide (2), photocatalyst fac-Ir(ppy)3, sodium acetate, and methanol are added to a 10 mL reaction tube and placed in a nitrogen atmosphere; Step 2: Under visible light irradiation, the reaction is stopped when the starting material α,α-diphenylallyl alcohol (1a) is completely consumed; Step 3: After the reaction is complete, the solvent is removed by vacuum distillation. The crude product is purified by rapid column chromatography to obtain α-aryl-β-difluoromethyl-substituted ketone compounds (3a). This reaction has the advantages of mild conditions, simple operation, broad substrate compatibility, and good functional group tolerance.

The application discloses a metal single-atom molecular sieve composite catalyst and a preparation method and application thereof. The metal single-atom molecular sieve composite catalyst comprises a molecular sieve and an active component; the molecular sieve is ZSM-23 molecular sieve; and the active component is an Fe-N-C species. The metal single-atom molecular sieve composite catalyst provided by the application is applied to a reaction of methane low-temperature oxidation for preparing C1 liquid products, and can realize direct oxidation of methane for preparing C1 liquid products under low-temperature conditions below 80 DEG C, and has outstanding catalytic activity, selectivity and good stability.

This application discloses a nonspecific peroxidase CsaUPO derived from *Cladorrhinum samala*, whose amino acid sequence is shown in SEQ ID NO:1. This enzyme efficiently catalyzes the 4,5β-epoxidation of testosterone to produce 4,5β-epoxidized testosterone, achieving a conversion rate of 98% and a separation yield of 90%, without producing hydroxylation byproducts, and exhibiting excellent regioselectivity. This application also discloses the gene encoding CsaUPO, the recombinant plasmid pPICZA-CsaUPO containing this gene, a recombinant Pichia pastoris engineered strain, and its application in steroid epoxidation. The nonspecific peroxidase CsaUPO disclosed in this application possesses advantages such as high catalytic efficiency, specific regioselectivity, a simple reaction system, and environmental friendliness, providing a new enzymatic resource for the site-directed epoxidation modification of steroid drugs.

The application belongs to the technical field of super-hydrophobic material preparation, and particularly relates to a simple preparation of super-hydrophobic silica nanowires and a method for constructing a super-hydrophobic coating. Alkyl chlorosilane and alkyl siloxane are used as structural reagents, and organic reagents with different water contents are used as solvents to initiate the hydrolysis and condensation of silane to prepare silica nanowires. The method is simple to operate, and the reaction conditions are mild, without the need to introduce acid or base catalysts. The prepared silica nanowires are sprayed onto the surface of a substrate to obtain a super-hydrophobic coating. The method is suitable for realizing low-cost, large-scale and rapid construction of super-hydrophobic coatings on various substrates, and has a wide application prospect.

The application discloses a photochemical cobalt catalytic synthesis method of arylamine compounds, uses bipyridine as a ligand, uses a cobalt salt as a catalyst, uses cheap and abundant aryl bromide and amine compounds as reactants, adds an organic base, and realizes synthesis of arylamine compounds by promoting C-N coupling reaction of aryl bromide and amine compounds through cobalt catalysis in an argon atmosphere. The reaction system is simple, the operation is simple, the reaction condition is mild, the post-treatment is simple, the target compound is good in selectivity and high in yield, the use of traditional expensive metal catalysts and inorganic bases is avoided, problems such as complicated catalytic system reaction and poor functional group compatibility are avoided, and the method has good application value and market prospect.