33results about How to "Simple reaction system" patented technology

The invention belongs to the technical field of perfume synthesis, and particularly relates to a method for efficiently preparing chiral oxo-ionol by an enzymic method, which comprises the following steps: putting a substrate containing oxo-ionone and an auxiliary substrate into a buffer solution, and stirring at room temperature until complete dissolution to obtain a substrate solution; the method comprises the following steps: dispersing carbonyl reductase ChKRED20 or a mutant thereof and coenzyme into a substrate solution, and carrying out heat preservation and stirring; and after the reaction is finished, adding water to dilute, extracting with ethyl acetate, washing with water, drying, and concentrating the ethyl acetate to obtain the chiral oxo-ionol. The enzyme catalysis method disclosed by the invention is mild in reaction condition and high in selectivity, and a target product can be obtained at high yield at room temperature and normal pressure. The coenzyme is regenerated by adopting a substrate coupling method, the use amount of the coenzyme is reduced, and a substrate coupling strategy that an auxiliary substrate is used as a substrate is adopted, so that a reaction system is simple, products are easy to separate, and the cost is reduced. According to the technical scheme, the conversion rate is greater than 99%, the ee value of the product reaches 99% or above, and the industrial application value is achieved.

The invention discloses a preparation method of sphere-like superfine copper powder. The preparation method comprises the following construction steps that raw materials are subjected to extraction, replacement, primary centrifugal separation, primary reduction, secondary centrifugal separation, secondary reduction, tertiary centrifugal separation, antioxidant coating and drying operation, and then the sphere-like superfine copper powder is finally obtained. The method solves the problems of large powder particle size and easy introduction of impurities in various existing superfine copper powder processing technologies, or the problems of expensive equipment, high cost, low yield and easy oxidation of prepared copper powder in preparation. According to the method, the traditional copper powder preparation process is improved, the reaction system is simplified, the reaction is more stable and controllable, the cuprous oxide and the copper are prepared by sequentially reducing the bivalent copper salt, the reaction protective gas is added in the secondary reduction, and the antioxidant is added, so that the prepared superfine copper powder is prevented from being oxidized in the air.

The invention discloses a method for preparing 2, 3-dimethyl-2, 3-phenylbutane through a continuous flow reaction, which comprises the following steps: respectively conveying raw materials cumene, a coupling initiator and an auxiliary agent into a mixer through a high-pressure metering pump, then entering a continuous flow reactor, and carrying out a coupling reaction at a certain reaction temperature and pressure for a certain retention time, thereby obtaining the 2, 3-dimethyl-2, 3-phenylbutane. And collecting the reaction liquid after the reaction is finished, and carrying out post-treatment to obtain the target product 2, 3-dimethyl-2, 3-phenylbutane. Wherein the auxiliary agent is an organic phosphine chelating agent. According to the present invention, with the continuous flow reactor, the preparation of the 2, 3-dimethyl-2, 3-diphenyl butane through the cumene coupling is achieved, the reaction system is simple, the cost is low, the reaction selectivity is good, the yield is high, the intrinsic safety is high, and the industrial production is easily achieved.

The invention belongs to the technical field of food safety, and particularly relates to a short-chain free fatty acid determination method and application thereof. The determination method of the short-chain free fatty acid comprises the following steps: S1, extracting the short-chain free fatty acid; s2, derivatization reaction of short-chain free fatty acid: under the protection of argon, adding a dichloromethane solution containing 1.5 mL of a fluorescent derivatization reagent into a drying flask containing 6mg of an extract, stirring for 2 hours at room temperature under the condition of blue light, and performing HPLC (High Performance Liquid Chromatography) determination after the reaction is finished; and S3, determining the short-chain free fatty acid. The novel and efficient fluorescent derivatization reagent is used in the determination method, and the determination method can improve the sensitivity and the accuracy of the HPLC method for determining the short-chain free fatty acid.

In the presence of an acidic reagent and an oxidizing agent, 2-indolone and indole are used as raw materials for one-step reaction to prepare the symmetric and asymmetric indole [2, 3-a] carbazole derivatives, the used raw materials, the acidic reagent and the oxidizing agent are cheap and easy to obtain, the reaction system is simple, the operation is simple, and the reaction steps are short (one-step reaction); the method has the advantages of wide substrate applicability, good functional group compatibility, mild reaction conditions, fast reaction speed, good chemical selectivity, realization of industrial production, and substantial economic and social benefits.

This invention discloses a method for the selective synthesis of 4-amino-N-(hetero)arylsulfonamide compounds. Using bipyridine as a ligand and nickel as a catalyst, and inexpensive and readily available low-activity (hetero)aryl chlorides and 4-aminobenzenesulfonamides as substrates, 1,8-diazabicycloundec-7-ene and other organic bases are used, along with sodium iodide and other additives. The synthesis of various 4-amino-N-(hetero)arylsulfonamide compounds is achieved through a photo-driven nickel-catalyzed selective C-N coupling reaction of (hetero)aryl chlorides and 4-aminobenzenesulfonamides under an argon atmosphere. This invention features a simple reaction system, convenient operation, mild reaction conditions, and simple post-processing. It exhibits good selectivity for target compounds and high yields, avoiding the problems of complex catalytic systems and poor functional group compatibility caused by the use of traditional expensive metal catalysts and inorganic bases. Therefore, it has significant application value and market prospects.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a method for synthesizing a polysubstituted olefin compound through olefin coupling. The method comprises the following step: reacting a compound A0 with a compound B0 under the action of an imidazoline-2-imine rare earth metal complex and an activator boron salt to obtain the polysubstituted olefin compound as shown in the formula I. According to the synthesis method, a series of polysubstituted olefin compounds can be obtained at high yield and high cis-trans ratio, the method is simple, efficient and environment-friendly, the substrate is good in universality, and the application prospect is wide. # imgabs0 #

The invention belongs to the technical field of preparation of 3-methylthio-propionaldehyde, and particularly relates to a preparation method of 3-methylthio-propionaldehyde, which comprises the following steps: S1, mixing 3-chlorphenyl-methyl sulfide with an inorganic alkali solution for reaction to obtain an intermediate 1; and S2, putting the intermediate 1 into a reaction kettle, sequentially adding a catalyst and an organic solvent, and oxidizing the intermediate 1 by taking air as an oxygen source to obtain the 3-methylthiopropionaldehyde. The synthesis method is simple and efficient, the reaction system is simple, the yield is high, the selectivity is good, oxygen or air is used as an oxygen source, the cost is low, toxicity is avoided, products obtained after oxidation reaction are few, byproducts difficult to treat cannot be generated, oxidation can be mildly achieved, smelly gas cannot be generated in the reaction process, the pressure in a reaction kettle is low, energy consumption is low, and the method is suitable for industrial production. And the requirements of green, energy-saving and sustainable development are met.

This invention relates to the visible light-induced synthesis of α-aryl-β-difluoromethyl-substituted ketone compounds. The method utilizes a photocatalytic strategy to construct valuable α-aryl-β-difluoromethyl-substituted ketone compounds through radical-mediated difluoromethylation and migration of 1,2-aryl groups. The method and synthetic steps include: Step 1: Using 80W blue light as a visible light source, α,α-diphenylallyl alcohol (1a), difluoromethyl ylide (2), photocatalyst fac-Ir(ppy)3, sodium acetate, and methanol are added to a 10 mL reaction tube and placed in a nitrogen atmosphere; Step 2: Under visible light irradiation, the reaction is stopped when the starting material α,α-diphenylallyl alcohol (1a) is completely consumed; Step 3: After the reaction is complete, the solvent is removed by vacuum distillation. The crude product is purified by rapid column chromatography to obtain α-aryl-β-difluoromethyl-substituted ketone compounds (3a). This reaction has the advantages of mild conditions, simple operation, broad substrate compatibility, and good functional group tolerance.

The invention relates to the technical field of organic synthesis, in particular to a synthesis method of a 3-hydroxyquinoline derivative, which comprises the following steps: adding reactants 1, 2, 3, 4-tetrahydroquinoline compound, a catalyst and a solvent into a reactor, reacting under stirring and heating conditions, and after the reaction is finished, performing post-treatment to obtain the target product 3-hydroxyquinoline derivative. According to the novel method for synthesizing the 3-hydroxyquinoline derivative, the hybrid material synthesized through coordination of the Mn-containing hydrotalcite and the organic acid is used as the catalyst, the 3-hydroxyquinoline derivative can be synthesized under the mild condition, and the method has the advantages of being low in raw material price, short in reaction process, mild in reaction condition and the like.

The invention belongs to the technical field of organic synthetic chemistry, and discloses a novel method for directional deuteration of a heterocyclic compound. The preparation of the deuterated heterocyclic compound is realized under mild reaction conditions by taking the heterocyclic compound as a raw material, heavy water as a deuterium source and HBeta zeolite as a catalyst. The method has the advantages of simplicity and convenience in operation, simple reaction conditions, high efficiency, greenness and the like, and has potential application value for realizing deuteration of the heterocyclic compound.

The application discloses a metal single-atom molecular sieve composite catalyst and a preparation method and application thereof. The metal single-atom molecular sieve composite catalyst comprises a molecular sieve and an active component; the molecular sieve is ZSM-23 molecular sieve; and the active component is an Fe-N-C species. The metal single-atom molecular sieve composite catalyst provided by the application is applied to a reaction of methane low-temperature oxidation for preparing C1 liquid products, and can realize direct oxidation of methane for preparing C1 liquid products under low-temperature conditions below 80 DEG C, and has outstanding catalytic activity, selectivity and good stability.

The invention discloses a polyfluorinated aryl substituted sulfone compound and a synthetic method and application thereof, the chemical structural formula of the polyfluorinated aryl substituted sulfone compound is # imgabs0. According to the synthetic method provided by the invention, under the photocatalytic condition, a polyfluorinated aromatic hydrocarbon compound, DABSO and potassium alkyl trifluoroborate are directly used as synthetic raw materials, and a higher yield can be obtained at normal temperature; the method is simple in process, environment-friendly and high in atom utilization rate, conforms to the green chemistry concept, and has excellent catalytic synthesis value and industrial application potential.

The invention relates to a method for synthesizing methyl cyclohexyl dicarbamate through catalytic transfer hydrogenation of a nitride-based catalyst. The method comprises the following steps: adding a nitride-based catalyst, a hydrogen source and toluene dicarbamate into a reaction kettle, and reacting at normal pressure and 40-120 DEG C for 1-10 hours to obtain methyl cyclohexyl dicarbamate, the nitride-based catalyst is a noble metal-auxiliary agent / transition metal nitride, and comprises an active metal, an auxiliary agent and a transition metal nitride. The method has the advantages of mild reaction conditions, low equipment cost, environmental friendliness, high process safety and the like. Meanwhile, the designed and prepared noble metal-assistant / transition metal nitride catalyst has the characteristics of high activity, high stability and high selectivity.

The invention belongs to the field of biomass energy and chemical industry, and particularly relates to a method for preparing furfuryl alcohol and isopropyl furfuryl ether by efficiently and selectively converting furfural. A zirconium-based bifunctional catalyst containing Lewis acid-base sites and # imgabs 0 # acid sites at the same time is prepared by using a strategy of synchronous hydrothermal carbonization sulfonation and subsequent coordination, and the catalytic sequence and catalytic activity of the Lewis acid-base sites and # imgabs 1 # acid sites can be accurately changed through simple operation of adjusting reaction conditions by a system, so that the conversion path and reaction degree of furfural are controlled; finally, directional selective synthesis of furfuryl alcohol and isopropyl furfuryl ether with high additional value can be realized in the same isopropanol system, and the catalyst prepared by the method also shows excellent catalytic stability and catalytic universality in the isopropanol system.

The invention discloses a preparation method of a 2-substituted quinazoline derivative, which comprises the following step: heating and stirring three components, namely an ammonium salt, a benzyl alcohol compound and a 2, 1-benzisoxazole compound in an organic solvent to obtain the 2-substituted quinazoline derivative. According to the method, ammonium iodide which is low in price and easy to obtain is used as a nitrogen source and an oxidizing agent, benzyl alcohol is used as a carbon source, and efficient construction from a 2, 1-benzisoxazole skeleton to a 2-substituted quinazoline skeleton is achieved through a carbon-nitrogen diatom inserted ring expansion reaction under the mild conditions of no metal and no additive. The synthetic method developed by the invention has a good application prospect in the industrial fields of biological medicines, pesticides and the like, and is particularly suitable for efficiently preparing the quinazoline compound with biological activity under simple and convenient conditions. The synthetic method developed by the invention has a good application prospect in the industrial fields of biological medicines, pesticides and the like, and a theoretical basis is provided for commercialized application of the derivatives in the field of medicines.

This invention relates to a method for preparing a kilogram-scale water-soluble nitrogen-containing actinide element extractant, comprising the following steps: S1. Synthesizing amide hydrazone via nucleophilic addition reaction: Adding hydrazine hydrate or anhydrous hydrazine to a dimethyl nitrile solution, performing a nucleophilic addition reaction, and then separating the solid and liquid phases to obtain the amide hydrazone; S2. Synthesizing pyridine triazine derivative via condensation cyclization reaction: Dispersing or dissolving the ground amide hydrazone and diphenylethylene glycol in a solvent, performing a condensation cyclization reaction, and then separating the solid and liquid phases to obtain the pyridine triazine derivative; S3. Obtaining the extractant via substitution reaction: Adding a sulfonating agent to the pyridine triazine derivative, refluxing to perform a substitution reaction, and then slowly adding the reaction mixture dropwise to a phase inversion agent to precipitate the extractant. Compared with the prior art, the preparation method of this invention is simple and feasible, with a simple reaction system, high product yield, short production cycle, simple processing technology, low energy consumption, inexpensive and readily available raw materials, and easy to industrialize, showing broad application prospects in the field of high-level radioactive waste disposal.

The invention discloses a method for preparing a 1, 4-sulfonylated chlorinated compound through a free radical reaction initiated by visible light, and belongs to the technical field of organic synthesis. The invention relates to a method for preparing a 1, 4-sulfonylated chlorinated compound through a free radical reaction initiated by visible light, which comprises the following steps: uniformly mixing a cyclobutyl olefin derivative, a sulfonyl chloride compound, alkali, a photosensitive catalyst and a solvent, and carrying out a visible light illumination reaction in a nitrogen atmosphere to obtain the 1, 4-sulfonylated chlorinated compound. According to the invention, the photocatalytic reaction is carried out in the presence of a small amount of the photosensitive catalyst, the preparation of the 1, 4-sulfonylated chlorinated compound can be realized under mild and green reaction conditions, and the method has the advantages of small catalyst dosage, simple reaction system and short reaction time.

The invention discloses a chromanone compound and application thereof in prevention and treatment of kiwifruit bacterial canker, the structural formula of the chromanone compound is # imgabs0, in the formula, R is one or more of hydrogen, alkyl, alkenyl, alkynyl, nitro, alkoxy, cyano, amino, sulfonic group, halogenated alkyl, aryl, heteroaryl and halogen; r'is alkyl or aryl. According to the synthesis method provided by the invention, 2-hydroxyacetophenone which is low in price and easy to obtain is used as a basic raw material for conventional chemical synthesis, and the reaction can be completed under mild conditions without a metal catalyst. The synthesis method has the advantages of simple reaction system, short reaction time and high yield, and can be used for green synthesis of chromanone compounds; meanwhile, the chromanone compound has an obvious control effect on kiwifruit bacterial canker pathogen.

The invention discloses a sulfonyl pyridazinone compound as well as a preparation method and application thereof, and the compound is characterized in that sulfonyl is introduced into 4-position C of pyridazine-3 (2H) ketone, so that the compound has multiple functional groups such as sulfonyl, phenyl and pyridazinone. The sulfonyl pyridazinone compound disclosed by the invention has a certain antibacterial effect on escherichia coli / staphylococcus aureus, and can be used for preparing broad-spectrum antibacterial drugs. Due to the characteristic of multiple flame-retardant functional groups, the compound is expected to be applied to the field of flame retardance. The invention also provides a preparation method of the sulfonyl pyridazinone compound, the preparation method is realized through a dehalogenation sulfonylation reaction of 4, 5-dihalo-2-phenylpyridazine-3 (2H) ketone and sulfonyl hydrazine, the reaction process does not have transition metal catalysis and does not need to add an oxidizing agent or a reducing agent, and the preparation method also has the characteristics of simple reaction system, wide substrate application range and relatively high yield, and is suitable for industrial production. The industrial production is facilitated.

The application belongs to the technical field of medicine, chemical industry and related chemistry, and discloses a preparation method of difluoromethyl arene compound based on palladium catalytic decarbonylation coupling. The method uses aryl boronic acid as a raw material, uses N, N-disubstituted difluoroacetamide compound as a difluoromethylation reagent, and prepares difluoromethyl arene compound under the catalysis of palladium, so that the green and efficient synthesis is realized. The method has the advantages of easy preparation and storage of the difluoromethylation reagent, high reaction selectivity, good functional group compatibility, wide substrate application range, environmental friendliness and the like. Since the difluoromethyl arene compound is an important functional molecular skeleton structure, the compound has very wide application in the fields of fine chemical industry and pharmacy, so that the application has great application value and social and economic benefits.

This application discloses a nonspecific peroxidase CsaUPO derived from *Cladorrhinum samala*, whose amino acid sequence is shown in SEQ ID NO:1. This enzyme efficiently catalyzes the 4,5β-epoxidation of testosterone to produce 4,5β-epoxidized testosterone, achieving a conversion rate of 98% and a separation yield of 90%, without producing hydroxylation byproducts, and exhibiting excellent regioselectivity. This application also discloses the gene encoding CsaUPO, the recombinant plasmid pPICZA-CsaUPO containing this gene, a recombinant Pichia pastoris engineered strain, and its application in steroid epoxidation. The nonspecific peroxidase CsaUPO disclosed in this application possesses advantages such as high catalytic efficiency, specific regioselectivity, a simple reaction system, and environmental friendliness, providing a new enzymatic resource for the site-directed epoxidation modification of steroid drugs.

The invention discloses a synthesis method of chiral cyclic ether, chiral cyclic ether and application thereof, and the synthesis method comprises the following step: in the presence of a catalyst, reacting a compound as shown in a structural formula I with hydrogen to obtain the chiral cyclic ether as shown in a structural formula II. The synthesis method is simple in reaction system, easy to operate and high in economic benefit.

The invention mainly relates to a synthetic method of 2-(indole-3-yl) phenol and a derivative thereof. According to the invention, under the action of the iodine catalyst, the oxidant and the acid additive, one-pot reaction of the indole compound and the cyclohexanone compound is realized to obtain the 2-(indole-3-yl) phenol and the derivative thereof with high selectivity, and the product with stable structure and excellent chemical property and the additional product thereof are prepared. The method disclosed by the invention has the characteristics of simple reaction system, mild reaction conditions, less reaction equipment, simplicity and convenience in experimental operation, wide material source, good atom economy, no need of adding a transition metal catalyst and the like, and a new synthesis path is provided for synthesis of the 2-(indole-3-yl) phenol compound. The 2-(indole-3-yl) phenol derivative and the synthetic method thereof can be used in the field of medicine production.

The application belongs to the technical field of super-hydrophobic material preparation, and particularly relates to a simple preparation of super-hydrophobic silica nanowires and a method for constructing a super-hydrophobic coating. Alkyl chlorosilane and alkyl siloxane are used as structural reagents, and organic reagents with different water contents are used as solvents to initiate the hydrolysis and condensation of silane to prepare silica nanowires. The method is simple to operate, and the reaction conditions are mild, without the need to introduce acid or base catalysts. The prepared silica nanowires are sprayed onto the surface of a substrate to obtain a super-hydrophobic coating. The method is suitable for realizing low-cost, large-scale and rapid construction of super-hydrophobic coatings on various substrates, and has a wide application prospect.

The invention discloses a method for synthesizing hydroxypinacolone retinoate through solvent-free continuous flow, and belongs to the technical field of organic synthesis. Compared with the existing similar methods, the method has the advantages that no additional organic solvent is needed in the reaction process, the raw material is used as the reaction solvent, the reaction system is simplified, the process cost is reduced, the post-treatment is simpler, and the reaction time is shorter; 20 min), the yield is higher (gt; 90%). And compared with an intermittent reaction process, the continuous flow reaction process has higher mass and heat transfer efficiency, the reaction time can be greatly shortened, the yield and the conversion rate are improved, the time loss of shutdown, cleaning, loading and unloading and the like in the traditional batch treatment process is avoided, personal errors among batches are reduced, and more stable product quality is provided.

The invention provides EB (Epstein-Barr) virus nucleic acid detection primers, a probe and a kit, according to a target sequence of an EB virus gene, the sequences of the primers and the probe in an asymmetric primer ERA detection system are designed and screened, and the ratio of upstream and downstream primers and an amplification reaction system are optimized, so that the EB virus nucleic acid sequence can be specifically identified, and the EB virus nucleic acid detection kit has the advantages of high specificity and high sensitivity. Non-specific binding with other irrelevant nucleic acids is reduced, so that the detection specificity is improved; meanwhile, efficient amplification of EB virus nucleic acid is realized, and the EB virus nucleic acid can be accurately detected even under the condition that the content of the virus nucleic acid is extremely low, so that the detection sensitivity and the amplification efficiency are improved.

The invention relates to the technical field of biological materials, in particular to a polydopamine coating as well as a preparation method and application thereof. According to the specific technical scheme, a dopamine solution and a hydrogen peroxide aqueous solution are mixed on the surface of a base material to be coated, and the polydopamine coating is generated. The prepared polydopamine coating can effectively improve the lower urinary symptoms such as pathological bladder mucous membrane barrier damage, erosion, bleeding, pain, frequent urination and urgent urination, mucous membrane repair is accelerated, and the life quality of a patient is improved. The technical scheme provided by the invention has a wide application prospect in the field of chemical cystitis treatment.

The invention belongs to the technical field of organic synthetic chemistry, and particularly relates to a method for synthesizing a photocatalytic asymmetric thioether compound. According to the invention, alkyl halide is taken as an initial raw material, a ruthenium complex is taken as a photocatalyst, phenylthiotrimethylsilane is taken as a sulfur source, cross coupling of C-S bonds under a photocatalytic condition is realized in an inert gas atmosphere through blue light irradiation, and a series of asymmetric thioether compounds are obtained at high yield. The synthesis method provided by the invention has the characteristics of greenness, environmental protection, mild conditions, high yield and the like. The asymmetric thioether compound disclosed by the invention is widely applied to the fields of medicines, pesticides, materials and the like, and the synthesis method provides a widely applicable preparation method for the compound.

The invention provides a method for synthesizing a benzenesulfonamide compound by taking substituted benzene and NFSI as raw materials and directly heating in the presence or absence of a solvent. Compared with the existing synthesis method of the benzenesulfonamide compound, the method has the advantages that the used reagent raw materials are simple and easy to obtain, any catalyst and additive are not needed, even the sulfonamide reaction of the electron-rich aromatic ring can be realized by a one-step method under the solvent-free condition, and the production cost is greatly saved; the range of reaction substrates is wide, and benzene with various substituent groups can react smoothly; the reaction efficiency is high, and corresponding products can be almost obtained at high yield in most reactions.