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Preparation of magnetic molecularly imprinted polymer and application in complex sample pre-processing

A magnetic molecular imprinting and complex sample technology, applied in the field of separation and analysis, can solve problems such as large consumption of organic solvents, low analysis efficiency, and time-consuming, achieving wide applicability, broad application prospects, and removal of matrix interference.

Inactive Publication Date: 2009-10-07
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Most of the traditional pretreatment methods require multiple operations, which not only consume a lot of organic solvents, but also take a lot of time, and the analysis efficiency is low

Method used

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  • Preparation of magnetic molecularly imprinted polymer and application in complex sample pre-processing
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  • Preparation of magnetic molecularly imprinted polymer and application in complex sample pre-processing

Examples

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Embodiment 1

[0034] Applying the contents of the present invention, ciprofloxacin is used as template molecule to prepare magnetic molecularly imprinted polymer. 1. The preparation of a magnetic molecularly imprinted polymer using ciprofloxacin as a template molecule comprises the following steps:

[0035] a. Preparation of Fe by chemical co-precipitation method 3 o 4 ferrofluid. 10mmol FeCl 2 4H 2 O and 20 mmol FeCl 3 ·6H 2 O was placed in a 250ml three-necked flask, and then 100ml of deionized water was added to dissolve it, mechanically stirred, nitrogen deoxidized, heated to 80°C, and 80mmol of NaOH solution was added at one time to react for 1.0h; after the reaction, the magnetic field was separated, and the magnet was placed At the bottom of the outer side of the three-necked bottle, attract Fe 3 o 4 , and then the waste liquid was poured out, and the Fe was washed with deionized water 3 o 4 until neutral, the resulting Fe 3 o 4 The mass of the magnetic fluid is 2.3g;

...

Embodiment 2

[0041] The establishment of a three-phase extraction system based on magnetic molecularly imprinted polymers with ciprofloxacin as a template molecule and its application in the extraction and separation of quinolone antibiotics in chicken samples (Note: Ciprofloxacin was used as a template molecule to prepare The magnetic molecularly imprinted polymer can simultaneously extract ciprofloxacin and its analogues such as levofloxacin, lomefloxacin, fleroxacin, enrofloxacin and sparfloxacin). like figure 1 shown, including the following steps:

[0042] a. Activation: Add 80 mg of the magnetic molecularly imprinted polymer with ciprofloxacin as the template molecule prepared in Example 1 into the Erlenmeyer flask, activate with 3.0 mL of methanol, separate by magnetic field, and pour off the waste liquid; Wash with mL deionized water to remove the methanol on the surface of the magnetic molecularly imprinted polymer with ciprofloxacin as the template molecule, separate with the ma...

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Abstract

The present invention specifically adopts a simple method for preparing a molecularly imprinted polymer and directly applies the molecularly imprinted polymer to the extraction separation of trace substance in the complex sample pre-processing. The invention adopts a chemical coprecipitation method for preparing Fe3O4 magnetofluid. Then the surface of Fe3O4 magnetofluid is modified with oleic acid. The template molecules and functional monomers are realized with preassembling and are mixed with the cross linker and modified magnetofluid. Then the mixture is added into the polymer solvent containing dispersing agent. After the reaction is finished, magnetic field separation is executed. The polymer is dried after eluting the formwork molecules. A three-phase extraction system which is established on the base of magnetic molecularly imprinted polymer can be directly applied to the extraction separation of complex samples of food, environment and biological sample. The method of the invention has excellent selectivity and can eliminate the matrix interference in the sample. Furthermore as the polymer has excellent magnetism, the polymer can excellently realize the separation to the sample matrix after the extraction, and the polymer has broad application prospect in the complex sample pre-processing.

Description

technical field [0001] The invention belongs to the technical field of separation and analysis, and specifically adopts a simple method to prepare a magnetic molecularly imprinted polymer, which is directly applied to the extraction and separation of trace substances in complex sample pretreatment. Background technique [0002] Complex systems, such as food, environmental samples, and biological samples are mostly mixtures of many different substances, and the content of the target components to be detected is often very low. Therefore, sample pretreatment is an extremely important step in the analysis of complex samples. Most of the traditional pretreatment methods require multiple operations, which not only consume a lot of organic solvents, but also take a lot of time, and the analysis efficiency is low. [0003] Molecular imprinting technology is a technology that uses artificial methods to prepare polymers that have specific binding effects on specific molecules and the...

Claims

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Application Information

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IPC IPC(8): C08F20/06C08F26/06C08F20/56
Inventor 丁兰陈立钢张晓盼徐阳金海燕
Owner JILIN UNIV
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