37results about How to "Improve treatment safety" patented technology

The invention discloses an intelligent system plaster capable of realizing automatic, dynamic and dialectical treatment on diseases and a preparation method of the intelligent system plaster. Aiming at the etiology and pathogenesis of the various diseases, traditional Chinese medicines of different prescriptions are adopted, the traditional Chinese medicines are prepared into plasters and/or ointment of different prescriptions through the steps including decocting and the like, the plasters and/or ointment of the different prescriptions are/is applied to the upper part (the Dazhui point), themiddle part (the Danzhong point, Shenque point and/or Shu points of the organs) and the lower part (double Yongquan points) of the human body and/or applied to the relevant points of the lesion localaffected part (Ashi point), and the intelligent dialectical treatment is realized through the integral treatment plaster system integrating the upper, middle and lower parts and by virtue of the automatic, dynamic and integral regulation mechanism of the five-organ integrated system of the human body. The intelligent system plaster provided by the invention has the efficacies of eliminating the pathogenic factors for strengthening the body resistance, elevating clear qi to lower turbid qi, guiding the qi movement and realizing integral conditioning. The intelligent system plaster mainly treatsvarious common diseases of the departments, such as a cold, a fever, cough and asthma, diarrhea, constipation, obesity, arthromyodynia, dizziness, rhinitis, haemorrhoids, acne, eczema and psoriasis.

The invention provides a chimeric antigen receptor. The chimeric antigen receptor comprises an extracellular region, a transmembrane region and an intracellular region, wherein the extracellular region comprises a single-chain antibody and a hinge region, the single-chain antibody comprises a heavy chain variable region of the single-chain antibody and a light chain variable region of the single-chain antibody, the single-chain antibody specially recognizes antigen human CD19, the hinge region comprises a human CD8 alpha extracellular segment containing 55 amino acid residues and 3 additionalamino acid residues AAA, and the AAA is located at the N terminal of the human CD8 alpha extracellular segment; the transmembrane region comprises a human CD8 alpha transmembrane segment, the human CD8 alpha transmembrane segment is connected with the hinge region of the extracellular region, and is embedded in the cell membrane of T lymphocyte; and the intracellular region comprises a human CD8 alpha intracellular segment containing 7 amino acid residues, a 4-1BB intracellular region and a CD3 zeta chain intracellular segment, and the intracellular region is connected with the human CD8 alphamolecule transmembrane segment.

The invention relates to the field of a drug preparation, and particularly relates to a powder injection for injection and a preparation method thereof. The powder injection for injection comprises a compound shown in the formula I and a freeze-drying protective additive, wherein the weight ratio of the compound shown in the formula I to the freeze-drying protective additive is (20-50): (100-250). The powder injection for injection provided by the invention is stable in quality, and high in treatment safety, and can be used for effectively treating deterioration of heart failure with a decreased left ventricular systolic function; and the preparation technology of the powder injection for injection is simple and convenient, controllable, and suitable for industrial production.

The present invention provides a transgenic lymphocyte, a construction product and a cancer treatment composition. According to the present invention, the transgenic lymphocyte expresses a nonfunctional EGFR receptor and a chimeric antigen receptor, can directionally kill tumor cells, and especially provides significant directional killing effect on glioblastoma having EGFRvIII mutation.

The invention provides a transgenic lymphocyte, a construct, and a therapeutic composition for treating cancer. The transgenic lymphocyte expresses a non-function EGFR and a chimeric antigen receptor.The chimeric antigen receptor comprises an extracellular region, which comprises the heavy-chain variable region and the light-chain variable region of a single-chain antibody that specifically recognizes the antigen MSLN; a transmembrane region, which is connected with the extracellular region and embedded into the cell membrane of a T lymphocyte; and an intracellular region, which is connectedwith the transmembrane region and comprises the intracellular segment of CD28 or 4-1BB and a CD3 zeta chain. The transgenic lymphocyte has the ability of directionally killing tumor cells, and particularly has remarkable directional killing effect on tumors with high expression of MSLN.

The invention relates to the field of medical instruments, in particular to a hypertrophic myocardium ablation system. Existing minimally invasive radio frequency ablation has various problems of difficulty in control of ablation range and depth, limited curative effect and the like. The invention provides a hypertrophic myocardial ablation system which comprises an ablation device and a console. The ablation device comprises a catheter, a handle and ablation electrodes; two ablation electrodes are provided and arranged in the far end of the catheter; the two ablation electrodes are respectively arranged at the ends of two electrode catheters; the two electrode catheters are hollow and penetrate through the catheter; a driving mechanism is arranged on the handle and can drive the electrode catheters to move, so that the ablation electrodes can stretch out of the far end of the catheter; the front portions of the two ablation electrodes are of a spiral shape; the front ends of the spiral shapes are tips; the spiral radius of the spiral shapes is gradually reduced from back to front; and the driving mechanism can drive the two ablation electrodes to carry out telescopic translation and rotating motion relative to the catheter. According to the invention, the pulse electric field energy can be deeply transferred into hypertrophy ventricular septal tissues to form partial and irreversible myocardial necrosis, and vascular nervous tissues cannot be affected.

A method for controlling a histotripsy using a confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses, including: 1) positioning a target tissue by a monitoring and guiding system and adjusting a position of the target tissue to a focal point of a transducer; 2) first stage: controlling the confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses to form a shock wave in a focal zone; wherein a negative acoustic pressure exceeds a cavitation threshold; an inertial cavitation occurs to generate boiling bubbles; the boiling bubbles collapse and achieve partial homogenization of the target tissue; 3) second stage: controlling the confocal fundamental and harmonic superposition combined with hundred-microsecond pulsed-ultrasound sequences to simultaneously irradiate a target zone and further mechanically disintegrate and homogenize the target tissue.

The invention discloses an intelligent system plaster for automatically, dynamically and overall dialectically conditioning constitution and preventing and curing diseases, and a preparation method ofthe plaster. According to different constitutions and the etiology and pathogenesis of various diseases, different formulas of traditional Chinese medicine are selected, plasters of different formulas are prepared through steps such as decoction and are respectively applied to related acupoints of a human body: the upper part (Baihui acupoint and/or Dazhui acupoint), the middle part (Danzhong acupoint, Shenque acupoint, Guanyuan acupoint and/ or Qihai acupoint, each Zang Fu Shu acupoint) and the lower part (Zusanli acupoints of both legs, Yongquan acupoints of both feet and/or double Sanyinjiao acupoints, double Xuehai acupoints), and intelligently and dialectically conditioning constitution and preventing and curing diseases are realized, through the 'trinity' overall conditioning composed of the upper, middle and lower parts and the integrated system of preventing-curing plaster, relying on the automatic and dynamic overall regulation mechanism of the five internal organ integration system of the human body. According to the present invention, the intelligent system plaster has the effects of harmonizing the middle cause, strengthening the healthy and removing pathogenic factors, raising the clear and reducing the turbidity, unblocking the Qi mechanism, and overall conditioning, and is used for conditioning constitution and preventing and curing various common diseases andsyndromes in various departments.

The embodiment of the invention discloses an intelligent closed-loop neural regulation and control system and method. The scheme comprises the following steps: predicting and classifying the collectedelectroencephalogram data of a target patient by a machine learning algorithm, so that the accuracy of preliminary judgment of the condition can be improved; and selecting a target interaction scenebased on the classification result, and performing disease interaction with the target patient in a preset interaction mode under the target scene, so that the condition of the patient can be furtherperfected, the accuracy of preliminary diagnosis is improved, the disease interaction result is fed back to a third party, the patient does not need to visit the doctor, and the previous condition ofthe patient can be diagnosed and analyzed according to the disease interaction result preliminarily determined by the intelligent closed-loop neural regulation and control system, and as a result, thepatient can see the doctor conveniently, and a relatively real and reliable reference basis is provided for the doctor to diagnose the condition. Therefore, the diagnosis efficiency is improved on the whole, the doctor-seeing difficulty is relieved, and the treatment cost is reduced.

The invention relates to a cold compress fixing device after a tonsillectomy. The device is characterized in that the device is formed by fixing an annular elastic band (1) and a corona-shaped semi-annular elastic band (2), and a junction (3) is arranged between the annular elastic band (1) and the corona-shaped semi-annular elastic band (2), widened, thickened and provided with a capsular bag (6)expanding outwards; the capsular bag is used for placing an ice bag, and the annular elastic band (1) is composed of a front arc surface (4) and a rear arc surface (5); the annular elastic band (1) and the corona-shaped semi-annular elastic band (2) are made of compact elastic nets separately. The cold compress fixing device has the advantages of being simple in structure, convenient to use, stable in fixation, high in treatment safety, free of complications, easy to apply and popularize, and capable of making patients comfortable.

The invention discloses an oxygen catheter device special for hyperbaric oxygen for a tracheotomy patient. The oxygen catheter device comprises a three-way pipe with an adjustable mounting angle; in the three-way pipe, one path is connected with a trachea cannula inner core through a connecting plug, and the other two paths are connected with an oxygen supply pipeline in a hyperbaric oxygen chamber and a pipeline used for exhausting exhaled waste gas respectively; and an upper end hole facilitating sputum suction is formed in the three-way pipe, and a hole plug matching the upper end hole is arranged in the upper end hole in the three-way pipe. According to the device, reliable guarantee is provided for oxygen uptake of the hyperbaric oxygen chamber tracheotomy patient, sputum suction operation of the tracheotomy patient is facilitated through the upper end hole formed in the three-way pipe, the operation sterility is guaranteed, the pollution is reduced, meanwhile, oxygen uptake time wasted by sputum suction is shortened, and stimulation caused by sputum suction to the patient is reduced.

The invention relates to the field of medicinal chemistry, and discloses compounds containing a benzimidazole structure as well as a preparation method and application thereof. The invention discloses the compounds of general formula (I) or pharmaceutically acceptable salts thereof, wherein: R1 represents H, COOH, COOR4 or CONHR4, and R4 represents hydrogen, C1-C6 alkyl; R2 represents hydrogen and C1-C5 alkyl; R< 3 > represents an optionally substituted benzene ring or heteroaromatic ring, the heteroaromatic ring is a six-membered or five-membered heteroaromatic ring, the substituent group is halogen, C1-C3 alkyl, alkoxy, halogenated alkyl, halogenated alkoxy, OH, NR5R6 or CN, and R < 5 > and R < 6 > represent hydrogen and C1-C6 alkyl. The compound can be used for treating tumors.

The invention discloses a semiconductor laser treatment device which comprises a laser emission head, a fixed cylinder is installed at the bottom end of the laser emission head, a distance adjusting assembly is installed in the fixed cylinder, the distance adjusting assembly comprises a movable cylinder inserted into the fixed cylinder, and an area adjusting assembly is installed at the bottom end of the movable cylinder. The movable cylinder can move relative to the fixed cylinder so as to adjust a laser light path; the area adjusting assembly comprises an installation ring installed at the bottom end of the movable cylinder, an installation groove is formed in the installation ring, a check block is installed in the installation groove, the outer side, the top wall and the bottom wall of the check block are all tightly attached to the inner wall of the installation groove, and the check block is made of an elastic piece; a heating coil is mounted on the inner wall of the mounting groove, is externally connected with a power supply, is tightly attached to the outer wall of the mounting groove and is used for heating the stop block. The problems that at present, the laser emitting area is not convenient to adjust, and adverse effects are likely to be caused to other parts of a patient are effectively solved.