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Pharmaceutical composition containing stem cell metabolite and preparation method thereof

A metabolite and composition technology, applied in the field of pharmaceutical composition containing stem cell metabolites and its preparation, can solve the problems of stem cell tumorigenesis, hepatic venous embolism, etc., to enhance the safety of treatment, reduce adverse reactions and tumorigenesis risk effect

Inactive Publication Date: 2016-12-28
朱冰 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the most common method of stem cell therapy is to use intravenous infusion or intrahepatic artery injection, but it may cause adverse reactions such as pulmonary embolism and hepatic venous embolism. It is important that stem cells enter the body with the risk of tumorigenesis, which is also the most important aspect of stem cell therapy. questioned question

Method used

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  • Pharmaceutical composition containing stem cell metabolite and preparation method thereof
  • Pharmaceutical composition containing stem cell metabolite and preparation method thereof
  • Pharmaceutical composition containing stem cell metabolite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0029] Embodiment 1. The method for preparing a pharmaceutical composition, comprising:

[0030] incubating a mixture comprising plasma and a cellular component comprising stem cells to obtain an incubated mixture;

[0031] The cellular components are separated from the incubated mixture to obtain a separated mixture.

Embodiment approach 2

[0032] Embodiment 2. The method of Embodiment 1, wherein the cellular component further comprises tissue cells selected from at least one of the following: epithelial cells, nerve cells, red blood cells, white blood cells, platelets, phagocytes (neutrophils) Granulocytes, basophils, eosinophils, etc.), lymphocytes, B lymphocytes, effector B cells, memory B cells, T lymphocytes, memory T cells, effector T cells, cardiomyocytes, smooth muscle cells, bone Muscle cells, cardiomyocytes, osteoblasts, glial cells, liver cells, kidney cells, gland cells, endocrine cells (thyroid cells, thymocytes, pancreatic islet B cells, pancreatic islet cells, and the above-mentioned tissue cells constructed and transformed by genetic engineering, etc.) .

Embodiment approach 3

[0033] Embodiment 3. The method of embodiment 1 or 2, wherein the stem cells comprise at least one selected from the group consisting of totipotent stem cells, multipotent stem cells, and pluripotent stem cells.

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Abstract

The invention relates to a pharmaceutical composition and a preparation method thereof. The preparation method comprises culturing a mixture containing blood plasma and cell components to obtain a cultured mixture, wherein the cell components contain stem cells, and separating the cell components from the cultured mixture so that a separated mixture is obtained. The pharmaceutical composition contains a stem cell metabolite and blood plasma.

Description

technical field [0001] The application relates to a pharmaceutical composition containing stem cell metabolites and a preparation method thereof. Background technique [0002] Stem cell therapy is a method to promote the regeneration of tissue cells, which can be used to treat various diseases related to tissue cells such as liver failure. It is currently believed that the therapeutic effect is closely related to the cytokines secreted by stem cells, but the current treatment method mainly uses stem cells Transplantation therapy, including intravenous infusion or hepatic arterial injection, has relatively large side effects and some potential risks. [0003] Hepatitis B related actue-on-chronic liver failure (HBV-ACLF) is the most common clinical liver failure in my country, and there is no reliable and effective treatment except liver transplantation. It is still as high as 56%. At present, the treatment methods for liver failure mainly include: medical drug therapy, artifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K35/16A61P31/20A61P1/16A61M1/02
CPCA61K45/06A61M1/0281A61K35/16A61K2300/00
Inventor 朱冰游绍莉
Owner 朱冰
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