10 results about "Propionic acid derivatives" patented technology

The invention discloses an aromatic propionic acid derivative as well as a preparation method, a pharmaceutical composition and application thereof. The invention specifically discloses a compound shown in a formula (I) or pharmaceutically acceptable salt thereof. The invention further discloses a pharmaceutical composition which comprises the compound shown in the formula (I), pharmaceutically acceptable salt of the compound and pharmaceutic adjuvants. The invention also discloses application of the compound as shown in the formula (I), the pharmaceutically acceptable salt of the compound or the pharmaceutical composition in preparation of drugs, and the drugs have GPR40 receptor agonistic activity and have one or more of the advantages of good activity, high targeting property, low toxicity and the like. # imgabs0 #

The invention relates to extended-release formulations comprising substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof that can activate adenosine 5'-monophosphate- activated protein kinase (AMPK). The invention further relates to methods of treating a condition comprising administering an extended-release formulation comprising AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof.

The invention discloses an aromatic ester propionic acid derivative as well as a preparation method and application thereof. The invention provides an aromatic ester propionic acid derivative as shown in a formula (I) or a pharmaceutically acceptable salt thereof. The invention further discloses application of the compound shown in the formula (I) or the pharmaceutically acceptable salt of the compound in preparation of drugs, and the compound has the effect of a GPR40 target agonist, so that the effects of reducing blood glucose and reducing weight are achieved. # imgabs0 #

The invention relates to extended-release formulations comprising substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof that can activate adenosine 5′-monophosphate-activated protein kinase (AMPK). The invention further relates to methods of treating a condition comprising administering an extended-release formulation comprising AMPK-activating substituted indazole propionic acid derivatives, pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof.

A chiral aryl propionic acid derivative and a pharmaceutical composition thereof, and a use. The chiral aryl propionic acid derivative is as shown in formula (I). The chiral aryl propionic acid derivative has antipyretic, analgesic and anti-inflammatory effects. The compound has high activity and can be locally administrated, a reduced dosage is expected, and adverse reactions are reduced.

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

The invention discloses a sulfur-containing aromatic propionic acid derivative as well as a preparation method, a pharmaceutical composition and application thereof. The invention specifically discloses a compound shown in a formula (I) or pharmaceutically acceptable salt thereof. The invention further discloses a pharmaceutical composition which comprises the compound shown in the formula (I), pharmaceutically acceptable salt of the compound and pharmaceutic adjuvants. The invention also discloses application of the compound as shown in the formula (I), the pharmaceutically acceptable salt of the compound or the pharmaceutical composition in preparation of drugs, and the drugs have GPR40 receptor agonistic activity and have one or more of the advantages of good activity, high targeting property, low toxicity and the like. # imgabs0 #

The invention discloses a substituted pyridine propionic acid derivative and application thereof, and belongs to the field of chemical medicines. According to the pyridine propionic acid compound shown in the general formula (I) or the pharmaceutically acceptable salt of the pyridine propionic acid compound, in the compound, an A ring, a B ring and a C ring are independently selected from X1, X2, X3 and X4 are independently selected from N and CR, and at least one of X1, X2, X3 and X4 in the A ring is N. The compound disclosed by the invention has an excellent Lp (a) inhibiting effect and can be used as a medicine for reducing the Lp (a) level of plasma.

The present invention relates to a substituted indazole propionic acid derivative of formula (I), a pharmaceutically acceptable salt thereof, a tautomer or a pharmaceutically acceptable salt of the tautomer, which can activate adenosine 5 '-monophosphate activated protein kinase (AMPK). The invention further relates to pharmaceutical compositions comprising a substituted indazole propionic acid derivative that activates AMPK, a pharmaceutically acceptable salt thereof, a tautomer or a pharmaceutically acceptable salt of the tautomer, and at least one pharmaceutically acceptable excipient; and methods of treating conditions comprising administering a substituted indazole propionic acid derivative that activates AMPK, a pharmaceutically acceptable salt thereof, a tautomer, or a pharmaceutically acceptable salt of the tautomer.

Disclosed are a sodium phenylamino propionic acid derivative, a preparation method and application thereof. Specifically, disclosed is sodium 3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)-2-((2-(4-(4-(2-sodium carboxylate-2-((2-(4-fluorobenzoyl)phenyl)amino)ethyl)phenoxy)benzoyl)phenyl)amino)propanoate as shown in formula (I), a preparation method thereof and a use thereof for quality control of a raw material or preparation of siglitinide or a derivative thereof. In particular, the compound of formula (I) can be used as a control or standard for impurity / related substance inspection in siglitinide or a sodium salt drug.