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Carbamazepine sustained-release tablet and preparation method thereof

A technology of carbamazepine and carbamazepine, which is applied in the field of carbamazepine sustained-release tablets and their preparation, and can solve problems such as difficulties

Active Publication Date: 2010-02-17
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After conventional preparations are taken, the drug concentration rises rapidly to the maximum value, and then decreases rapidly due to metabolism, excretion and degradation. It is difficult to control the drug concentration between the minimum effective concentration and the maximum safe concentration;

Method used

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  • Carbamazepine sustained-release tablet and preparation method thereof
  • Carbamazepine sustained-release tablet and preparation method thereof
  • Carbamazepine sustained-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] prescription:

[0031] Carbamazepine 200g

[0032] Hypromellose K100 90g

[0033] Microcrystalline Cellulose 101 20g

[0034] Mannitol 200SD 120g

[0035] Povidone K30 15g

[0036] Magnesium Stearate 4g

[0037] Amount of ethanol

[0038] Make 1000 pieces

[0039] Formulation process

[0040] 1 prepare the povidone ethanol solution to get the povidone of the recipe quantity and make the ethanol solution of 10% (w / w), for subsequent use;

[0041] 2 Granulation After sieving carbamazepine and mannitol with 80 meshes respectively, put them into a mixing granulator together with hypromellose and microcrystalline cellulose for mixing, and then add povidone ethanol solution for wet granulation. granules, take out the granules and carry out wet granulation with a 20-mesh sieve. After drying, pass through a 20-mesh sieve to granulate and set aside.

[0042] 3. Tabletting After mixing the obtained granules and the prescribed amount of magnesium stearate evenly, the con...

Embodiment 2

[0044] prescription:

[0045] Carbamazepine 200g

[0046] Hypromellose K4M 120g

[0047] Microcrystalline Cellulose 101 30g

[0048] Mannitol 200SD 150g

[0049] Copovidone S630 30g

[0050] Magnesium Stearate 5g

[0051] Amount of ethanol

[0052] Make 1000 pieces

[0053] Formulation process

[0054] 1 prepare the povidone ethanol solution to get the povidone of the recipe quantity and make the ethanol solution of 10% (w / w), for subsequent use;

[0055] 2 Granulation After sieving carbamazepine and mannitol with 80 meshes respectively, put them into a mixing granulator together with hypromellose and microcrystalline cellulose for mixing, and then add povidone ethanol solution for wet granulation. granules, take out the granules and carry out wet granulation with a 20-mesh sieve. After drying, pass through a 20-mesh sieve to granulate and set aside.

[0056] 3. Tabletting After mixing the obtained granules and the prescribed amount of magnesium stearate evenly, the co...

Embodiment 3

[0058] prescription:

[0059] Carbamazepine 200g

[0060] Hypromellose K4M 30g

[0061] Hypromellose E5 90g

[0062] Microcrystalline Cellulose 101 30g

[0063] Mannitol 200SD 150g

[0064] Povidone K30 57g

[0065] Magnesium Stearate 5g

[0066] Amount of ethanol

[0067] Make 1000 pieces

[0068] Formulation process

[0069] 1 prepare the povidone ethanol solution to get the povidone of the recipe quantity and make the ethanol solution of 10% (w / w), for subsequent use;

[0070] 2 Granulation After sieving carbamazepine and mannitol with 80 meshes respectively, put them into a mixing granulator together with hypromellose and microcrystalline cellulose for mixing, and then add povidone ethanol solution for wet granulation. granules, take out the granules and carry out wet granulation with a 20-mesh sieve. After drying, pass through a 20-mesh sieve to granulate and set aside.

[0071] 3. Tabletting After mixing the obtained granules and the prescribed amount of magne...

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Abstract

The invention aims to provide a carbamazepine sustained-release tablet having higher medicament release stability and higher medication security. The carbamazepine sustained-release tablet is characterized by consisting of an effectively therapeutic dose of carbamazepine and physiologically acceptable pharmaceutic adjuvant, and has the characteristics of convenient administration, lasting effect,stable curative effect, small toxic and side effect and the like.

Description

technical field [0001] The invention relates to a carbamazepine sustained-release tablet and a preparation method thereof, belonging to the field of medicine. technical background [0002] Carbamazepine has anticonvulsant and trigeminal neuralgia pharmacological effects, and is clinically used for: 1. Epilepsy, most effective for complex partial seizures, secondary epilepsy, primary grand mal seizures, simple partial seizures and mixed type Epilepsy is also effective; 2. Relieve trigeminal neuralgia and glossopharyngeal neuralgia, prevent or treat bipolar manic depression, and central partial diabetes insipidus. [0003] Epilepsy is one of the most common central nervous system disorders, with an even higher incidence than Alzheimer's, and seizures can occur at any time. There are approximately 2.3 million cases of epilepsy in the United States, with an estimated 61,000 new cases each year. The reported incidence of epilepsy in my country is about 25.3 / 100,000 of the popul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/55A61P25/08A61P25/02
Inventor 郑顺利李育巧林鹏
Owner COSCI MED TECH CO LTD
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