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Suspension composition for treating oral mucositis caused by chemoradiotherapy

A technology for oral mucositis and suspension, which is applied to the active ingredients of heterocyclic compounds, drug combinations, digestive system, etc., can solve the problems of no central sedative and hypnotic effects, and achieve the effects of low production cost, small side effects, and good safety

Inactive Publication Date: 2012-01-18
何雪心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diphenhydramine has a good antihistamine effect, and has a certain local anesthetic effect and central sedative hypnotic effect, which is more suitable for some patients with oral ulcer pain; while levocetirizine has a good antihistamine effect, But it has no central sedative and hypnotic effect, and it is also suitable for some patients

Method used

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Experimental program
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Embodiment Construction

[0062] The present invention will be further described below in conjunction with specific implementation examples.

[0063] 1. The efficacy of the main components

[0064] 1. Local anesthetics

[0065] 1) Ropivacaine mesylate: This product is a new type of long-acting amide local anesthetic. Blockade (analgesia) is only accompanied by limited non-progressive motor nerve blockade, and its effect lasts for a long time, with a half-life of 4 to 6 hours. Its pharmacological characteristics are low cardiotoxicity, obvious separation of sensory block and motor block, peripheral vasoconstriction, delaying anesthetics entering the systemic circulation, and maintaining local tissue concentration. Therefore, the drug is especially suitable for local topical anesthesia of the mucosa.

[0066] Compared with traditional local anesthetics, ropivacaine mesylate has the following advantages:

[0067] ①Curative effect - the action time of ropivacaine mesylate is significantly longer than tha...

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Abstract

The present invention discloses a suspension composition for treating oral mucositis caused by chemoradiotherapy, and relates to a new drug for treating oral mucositis. The suspension composition comprises: 1, local anesthetics; 2, histamine 1 receptor antagonists; 3, a mucosal repairing agent and a drug dispersing agent; 4, an anti-foaming agent; 5, microcrystalline cellulose; 6, unreactive assistant materials; 7, pure water. The preparation method comprises: 1, preparing a solution I; 2, preparing a solution II; 3, adding the solution I to the solution II at a stirring state, completely stirring, adjusting the pH value of the mixed solution to 6-9 to obtain the suspension composition. According to the present invention, the suspension composition provided by the present invention has characteristics of good uniformity and strong stability, is not easy to agglomerate when the suspension composition is placed for a long time; the preparation method has characteristics of simple process and low production cost; the suspension composition can be applicable for treating the oral mucositis caused by the chemoradiotherapy, and severe mouth ulcers caused by anaerobic bacteria; the suspension composition provides effects of analgesia, inflammation eliminating and mucosa repairing; the clinical efficacy of the suspension composition is obvious; the use of the suspension composition is convenient and safe.

Description

technical field [0001] The invention relates to a new drug for treating oral mucositis, in particular to a suspension composition for treating oral mucositis caused by chemoradiotherapy. Background technique [0002] The incidence of tumor has increased significantly in recent decades, and it has become the number one killer affecting human health. At present, the main means of treating tumors include surgery, radiotherapy and chemotherapy. Oral mucositis is a common complication of cancer patients receiving chemoradiotherapy, especially in patients receiving head and neck radiotherapy, and its incidence rate is nearly 100%. Oral mucositis often occurs in non-keratinized mucosa such as the lips, cheeks, soft palate, and the bottom of the tongue and the ventral surface of the tongue. The main manifestations are mucosal erythema, edema, ulcers, pain, and eating disorders. At the same time, the risk of secondary infection increases. . The occurrence of mucositis forces the d...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K33/08A61K47/38A61P1/02A61K31/135A61K31/167A61K31/381A61K31/445A61K31/495A61K33/06
Inventor 何雪心左克源
Owner 何雪心
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