104 results about "Chemo-radiotherapy" patented technology

The invention discloses poplar and phellinus igniarius polysaccharide SVP-1 as well as a preparation method and application thereof, and belongs to the field of biological medicines. The poplar phellinus igniarius polysaccharide SVP-1 provided by the invention has remarkable anti-tumor activity, and can effectively inhibit proliferation, invasion and migration of tumor cells so as to block malignant progression of tumors. The structure is clear, the preparation method is controllable, the stability and biological activity of polysaccharide components are ensured, and a reliable basis is provided for development of antitumor drugs. When the traditional Chinese medicine composition is used together with radiotherapy and chemotherapy medicines, a synergistic effect can be achieved, the sensitivity of tumors to treatment can be improved, the toxic and side effects of radiotherapy and chemotherapy can be relieved, and the effects of reducing toxicity and increasing efficiency are achieved. According to the combined treatment strategy, the curative effect of the existing tumor therapy can be remarkably improved, meanwhile, adverse reactions are reduced, and a new optimization scheme is provided for clinical tumor treatment.

The invention relates to a double-cavity radiotherapy and chemotherapy integrated treatment capsule for brain glioma, which aims to solve the problems that the existing radioactive seed source or chemotherapy carrier cannot give consideration to radiotherapy and chemotherapy, the dosage is difficult to regulate and control, the medicine distribution is non-uniform and the like. The brain glioma double-cavity radiotherapy and chemotherapy integrated treatment bag is composed of a radiotherapy pipeline and a chemotherapy pipeline, the whole integrated treatment bag is a spiral pipe body, the radiotherapy pipeline is located in an inner ring, the chemotherapy pipeline is located in an outer ring, the radiotherapy pipeline is a closed cavity, a liquid radioactive source is contained in the closed cavity, and the liquid radioactive source is located in an outer ring. The chemotherapy medicine is released from the head end of the chemotherapy pipeline, the chemotherapy medicine is injected from the tail end of the chemotherapy pipeline, and the surface of the integrated treatment bag is coated with a composite antibacterial layer. According to the integrated treatment capsule, radiopharmaceuticals and chemical drugs are placed in the inner cavity and the outer cavity respectively, synergistic treatment of radiotherapy and chemotherapy is achieved through the synchronous effect of the two channels, and long-term low-dose release of the radiopharmaceuticals and the chemotherapy drugs is achieved and toxic and side effects are reduced by adjusting the screw pitch and the thickness of the tube wall.

The invention discloses an intelligent pulse acupoint electrode stimulation radiotherapy and chemotherapy side effect relieving device, and relates to the technical field of medical auxiliary equipment, the intelligent pulse acupoint electrode stimulation radiotherapy and chemotherapy side effect relieving device comprises a machine body and an electric pulse therapeutic apparatus main body, one side of the electric pulse therapeutic apparatus main body is provided with two sockets, and two connectors are movably inserted into the two sockets; one ends of the two connectors are connected with four electrode patches through two connecting wires. According to the device for relieving side effects of radiotherapy and chemotherapy through intelligent pulse acupoint electrode stimulation, by arranging an intelligent limiting anti-falling mechanism, stable limiting of one or two connectors is achieved, and the problem that in the using process of an existing electric pulse therapeutic instrument device, the existing electric pulse therapeutic instrument device is not prone to falling off is solved. In the prior art, a connecting port on an electric pulse therapeutic apparatus is often connected with a connecting wire through a connector in an inserted manner, but the connecting wire is easy to loosen and fall off from the electric pulse therapeutic apparatus due to pulling, friction or vibration of an external force in the therapeutic process of a user, and the therapeutic continuity is further influenced.

The invention discloses a traditional Chinese medicine composition for reinforcing qi, nourishing blood and strengthening body resistance after tumor chemoradiotherapy and a detection method thereof. The traditional Chinese medicine composition is prepared from astragalus membranaceus, codonopsis pilosula, angelica sinensis, poria cocos, cistanche, caulis spatholobi, radix paeoniae alba, glossy privet fruit, eclipta, hairyvein agrimony, medlar, Chinese yam, radix rehmanniae, radix ophiopogonis, deer-horn glue, tortoise-shell glue, pericarpium citri reticulatae and liquorice. The optimal traditional Chinese medicine composition and dosage are screened out through a large number of experimental screening and clinical medication experience, treatment is conducted on the basis of syndrome differentiation, compatibility is reasonable, the effects of reinforcing qi, nourishing blood and strengthening the body resistance are achieved together, immunity is improved, and the traditional Chinese medicine composition can be used for tumor chemoradiotherapy and postoperative conditioning and treatment of symptoms such as anemia, bone marrow suppression, thrombocytopenia and elderly weakness. Content determination is carried out through TLC identification and HPLC, and a scientific basis is provided for guaranteeing the clinical quality and effectiveness of reinforcing qi, nourishing blood and strengthening body resistance.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine electuary for intestinal injury caused by radiotherapy and chemotherapy and a preparation method of the traditional Chinese medicine electuary. According to the composition principle of monarch, minister, assistant and guide of a traditional Chinese medicine prescription, the traditional Chinese medicine electuary is prepared by taking radix astragali preparata as a monarch drug, taking radix codonopsis and rhizoma polygonati as minister drugs, and taking poria cocos, bran-fried rhizoma atractylodis macrocephalae, hairyvein agrimony, Chinese pulsatilla root, rhizoma bletillae and pinellia ternate as assistant drugs, and taking pericarpium citri reticulatae, vinegar-processed curcuma zedoary, pseudo-ginseng and musk as assistant drugs through scientific compatibility and a preparation process. The intestinal function can be adjusted, and the intestinal injury symptom caused by radiotherapy and chemotherapy is improved.

The application provides a preparation method of high-selenium compound powder for postoperative and radiotherapy rehabilitation immune repair, and belongs to the technical field of functional food or special medical use formula food processing technology.The application realizes sufficient wall breaking by respectively pre-wetting and low-temperature complex enzymolysis of hard plant wall and fungal wall raw materials, and then prevents active loss by using endogenous substances of the raw materials for in-situ anchoring without adding, after drying and crushing, adding postbiotic powder, active peptide, whey protein, yeast beta-glucan, EGCG and other heat-sensitive components into low-temperature sterile dry mixing, while maximizing the release of organic selenium and immune active substances, the heat-sensitive functional components are completely protected from degradation and inactivation, and finally the technical target of sufficient wall breaking, complete activity and stable immune repair effect is achieved.The product prepared by the application can improve the immune organ damage and immune homeostasis imbalance caused by radiotherapy, and is suitable for the immune repair of postoperative and radiotherapy rehabilitation population.

The present invention discloses a nutritional care intervention system and method for tumor radiotherapy and chemotherapy patients, belonging to the field of nutritional care intervention. The present invention obtains patient data, obtains patient basic information, treatment plans and constructs a dynamic knowledge base, constructs a nutritional element intake gap model, imports the recommended daily intake and actual intake of nutritional elements of the patient into the nutritional element intake gap model to evaluate the nutritional gap, constructs a drug metabolism and organ tolerance model, imports radiotherapy and chemotherapy drug parameters into the drug metabolism and organ tolerance model to evaluate the drug metabolism situation and organ tolerance dose, constructs a nutritional risk assessment model, and imports the relative nutritional element gap vector, drug metabolism amount, organ tolerance dose, and patient tumor stage into the nutritional risk assessment model to evaluate the patient's nutritional risk. The present invention comprehensively evaluates the patient's nutritional risk based on the patient's nutritional intake situation, drug metabolism process and organ tolerance, and conducts nutritional care intervention on the patient.

The invention relates to the technical field of virtual reality medical treatment, and discloses a head and neck cancer chemoradiotherapy related symptom remote monitoring and multi-sensory intervention method based on VR, and the method comprises the following steps: S1, a patient carries out preliminary evaluation through a first input module of a VR terminal, and transmits monitoring data to a data processing module through the VR terminal; s2, performing secondary evaluation on the average score or the symptom of which any score is in a second interval in a targeted manner through a first input module of the VR end, and sending a multi-sensory first-level intervention request or a multi-sensory second-level intervention request or a multi-sensory third-level intervention request to the VR end by a data processing module according to the score condition of the symptom; and S3, after the patient completes corresponding intervention, performing post-intervention evaluation through the first input module of the VR end, and comparing the evaluation conditions before and after intervention by the data processing module to generate an intervention effect evaluation report. Related symptoms of a patient can be dynamically monitored in real time, symptom changes can be found in time, corresponding intervention is given, treatment interruption is prevented, and the lifetime is prolonged.

The invention relates to the technical field of medical information systems, in particular to a nursing system for tumor patients in a chemoradiotherapy period, which comprises a physiological monitoring module, a threshold evaluation module, a path switching module, a task decomposition module and a nursing scheduling module. According to the method, by continuously collecting multi-dimensional physiological data such as the heart rate, the blood oxygen saturation degree, the blood pressure and the serum creatinine of the patient and conducting noise suppression processing, stable bearing state information can be obtained, and dynamic quantitative evaluation of the tolerance degree is achieved in combination with deviation analysis of the nursing base line; the nursing task is subjected to priority and rhythm adjustment when the bearing index exceeds the limit, the high-load task is split by utilizing fluctuation prediction, and the interval duration is set, so that the risk caused by physiological burden concentration is reduced, the nursing execution rhythm matched with the real-time state of a patient is formed, and the flexibility of load distribution and the instantaneity of intervention response are realized. And the accuracy and safety of whole-course nursing are improved.

This invention belongs to the field of tumor treatment, specifically relating to the application of a CHK1 inhibitor in the preparation of drugs that weaken radiotherapy and chemotherapy resistance in nasopharyngeal carcinoma. This invention is the first to clearly demonstrate that F-circRM mediates radiotherapy and chemotherapy resistance by activating the CHK1 signaling pathway, enhancing the DNA damage repair capacity of nasopharyngeal carcinoma cells, and thus mediating the core mechanism. The CHK1 inhibitor can effectively block this pathway, significantly enhancing the sensitivity of nasopharyngeal carcinoma to radiotherapy and chemotherapy and reversing radiotherapy and chemotherapy resistance in in vitro multi-cell lines, patient-derived primary cells, and in vivo animal models. This invention also clarifies that F-circRM can serve as a biomarker for predicting the efficacy of radiotherapy and chemotherapy, providing a basis for stratification and individualized treatment plans for nasopharyngeal carcinoma patients, and has significant clinical value and broad application prospects.

The invention discloses mouthwash for treating oral ulcer caused by chemoradiotherapy, which is mainly prepared from the following raw materials in percentage by weight: 0.15 percent to 0.25 percent of chlorhexidine gluconate, 0.015 percent to 0.025 percent of polypeptide of which the amino acid sequence is RWRWRW, 0.05 percent to 0.15 percent of sodium hyaluronate, 0.05 percent to 0.15 percent of menthol, 2.8 percent to 3.2 percent of humectant, 0.45 percent to 0.55 percent of sodium ascorbyl phosphate, 0.5 percent to 1 percent of sodium bicarbonate and the balance of distilled water. The mouthwash for treating the oral ulcer caused by the chemoradiotherapy not only has antibacterial and moisturizing functions, but also can relieve the pain degree of the oral ulcer caused by the chemoradiotherapy, reduce the infection risk and promote ulcer healing, the technical problem that an existing product is single in function is solved, a patient does not need to alternately use multiple preparations, and the compliance is high.

This application relates to the technical field of traditional Chinese medicine compositions, specifically disclosing a traditional Chinese medicine composition for treating deficiency syndromes caused by illness, surgery, radiotherapy, and chemotherapy, and its preparation process. The composition comprises Ganoderma lucidum extract and ginseng powder. The preparation method of the Ganoderma lucidum extract is as follows: Step 1, pulverizing the raw material to obtain Ganoderma lucidum powder; Step 2, extraction: extracting the Ganoderma lucidum powder with a primary liquid-liquid phase solvent for 1.5-2.5 hours, adding non-oxidizing gas nano-bubble water and extracting for 0.5-1.5 hours, then adding acidic gas nano-bubble water and continuing extraction for 0.5-1.5 hours; Step 3, collection: collecting the extract, concentrating, forming a paste, and drying to obtain the Ganoderma lucidum extract; the primary liquid-liquid phase solvent includes an alcohol solution with a volume ratio of (2-5):1 and a non-polar organic solvent, with the alcohol volume percentage in the primary alcohol solution being 65-90%. The composition of this application has a higher content of Ganoderma lucidum polysaccharides and Ganoderma lucidum triterpenes.

Provided are a human NBS1 protein antigen lactylated at lysine 388, an antibody, a preparation method therefor, and a use thereof, relating to the technical field of biomedicine. A human NBS1 protein antigen peptide lactylated at lysine 388 is provided, and is used to prepare an antibody targeting lactylation at lysine 388 of human NBS1 protein. The antibody targeting lactylation at lysine 388 of human NBS1 protein can detect expression differences among normal cells, tumor cells, and drug-treated tumor cells, thereby helping to study the role of lactylation modification of human NBS1 protein in the occurrence and development of tumor diseases, and providing potential therapeutic targets for clinical diagnosis or treatment of tumor diseases. The antibody targeting lactylation at lysine 388 of human NBS1 protein can be used to detect the lactylation level of human NBS1 protein, and to investigate its relationship with tumor diagnosis and resistance to radiotherapy and chemotherapy, thereby offering broad clinical application prospects in disease diagnosis, treatment, and prognosis evaluation.

The application relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound preparation for treating solid tumors and promoting blood circulation to remove blood stasis and a preparation method and application thereof. Under the guidance of traditional Chinese medicine theory, according to the syndrome manifestations of patients with solid tumors (early, middle and late stages), the traditional Chinese medicine compound preparation prepared from the animal traditional Chinese medicines gecko, sea squirts and leeches and the plant traditional Chinese medicines notoginseng, madder, safflower and licorice in a certain proportion is used to treat patients with blood stasis syndrome of malignant tumors, can obviously improve the life quality of the patients, reduce the toxic and side effects of radiotherapy and chemotherapy, prolong the survival period of the patients and improve the symptoms of blood stasis syndrome of the patients.

The invention provides a traditional Chinese medicine composition for treating myelosuppression. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 45-55 parts of astragalus membranaceus, 20-30 parts of glossy privet fruit, 15-25 parts of rubia yunnanensis, 45-55 parts of caulis spatholobi, 20-30 parts of polygonum cuspidatum, 15-25 parts of radix ranunculi ternati and 25-35 parts of wild buckwheat. The invention further provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has the effects of strengthening the body resistance, tonifying deficiency and enhancing the immune function of a patient, improves the tolerance of a tumor patient to an anti-tumor drug, and is particularly suitable for prognosis treatment of a lung cancer patient with deficiency of both qi and yin. The traditional Chinese medicine composition can improve the myelosuppression symptom after anti-tumor medicine treatment (such as chemoradiotherapy), has the effects of increasing the capacity of white blood cells, red blood cells, blood platelets, bone marrow DNA, hematopoietic stem cells or / and hematopoietic tissues and treating cancer fatigue and / or consumptive disease, and plays the optimal effect at a low dosage. The preparation method is simple and is suitable for large-scale production, popularization and application.

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for reducing adverse reactions after radiotherapy and chemotherapy of tumor patients and a preparation method thereof, comprising the following components in parts by weight: Radix Bupleuri 6-9 parts, Radix Paeoniae Alba 6-9 parts, Rhizoma Atractylodis Macrocephalae 6-9 parts, Poria 6-9 parts, Angelica sinensis 6-9 parts, Zingiber officinale 3 parts, Radix Rehmanniae Recens 3-6 parts, Gardenia 3-6 parts, Radix Paeoniae Rubra 3-6 parts, Radix Paeoniae Alba 12-20 parts, Rhizoma Chuanxiong 6 parts, and Radix Glycyrrhizae 3-6 parts; the traditional Chinese medicine composition can improve the spirit and movement state of mice, and the weight and food intake of mice are obviously increased, the number of dead mice is significantly reduced, and the tumor volume and weight of mice are significantly reduced; the spleen and thymus indexes, the number of white blood cells, red blood cells and platelets in peripheral blood, and the hemoglobin content are all significantly increased; the number of bone marrow cells and the CD4 + T / CD8 + T cell ratio in peripheral blood are all significantly increased; when applied to clinical patients, the traditional Chinese medicine composition can reduce adverse reactions after radiotherapy and chemotherapy of tumor patients, and has a broad application prospect.

A method, system, device, and medium for processing symptom cluster data of head and neck cancer patients based on sentinel symptoms are disclosed. The method includes: obtaining symptom data of head and neck cancer patients during radiotherapy and chemotherapy through longitudinal surveys; processing the symptom data using exploratory factor analysis to extract several symptom clusters; performing association rule analysis on the symptom cluster data based on the Apriori algorithm, and determining the sentinel symptoms within each symptom cluster by combining the time of first symptom appearance; and constructing an intervention plan for gastrointestinal symptoms using the sentinel symptoms as intervention targets. This invention achieves accurate determination of sentinel symptoms through longitudinal survey data, combined with the Apriori algorithm and the time of first symptom appearance, and constructs intervention plans based on the MRC complex intervention framework, realizing early symptom identification and providing precise and personalized symptom management support for head and neck cancer patients.

The application discloses poplar phellinus polysaccharide SVP-1, a preparation method and application thereof, and belongs to the field of biological medicines. The poplar phellinus polysaccharide SVP-1 provided by the application has significant antitumor activity, can effectively inhibit the proliferation, invasion and migration of tumor cells, and thus blocks the malignant progression of tumors. The structure is clear, the preparation method is controllable, the stability and biological activity of the polysaccharide component are ensured, and a reliable foundation is provided for the development of antitumor drugs. The combination with radiotherapy and chemotherapy drugs can play a synergistic effect, can not only improve the sensitivity of tumors to treatment, but also reduce the toxic and side effects of radiotherapy and chemotherapy, and realizes the effect of 'attenuation and synergism'. The combined treatment strategy can significantly improve the curative effect of the existing tumor therapy, while reducing the adverse reactions, and provides a new optimization scheme for clinical tumor treatment.

This invention belongs to the field of biomedical technology, specifically relating to triptolide liposomes (TP-lipo), their combined use, and their application in the prevention and treatment of tumors. To enhance the efficacy of triptolide in the treatment and prevention of tumors such as pancreatic cancer, cervical cancer, ovarian cancer, and colorectal cancer, and to improve its bioavailability and clinical application while reducing toxicity, this invention uses HSPC, DOPS, and cholesterol as liposome components to encapsulate triptolide monomers, thus preparing TP-lipo. Experiments have shown that TP-lipo exhibits anti-tumor activity: it directly kills tumor cells and reverses the immunosuppressive microenvironment, making it a potential drug for tumor treatment. TP-lipo, when used in combination with PD-1 antibodies, or in combination with radiotherapy, chemotherapy, or surgery, demonstrates a potent and synergistic anti-tumor effect with low toxicity. Therefore, the TP-lipo of this invention provides more clinical strategies for tumor treatment.

The invention discloses an effective part for chemoradiotherapy-induced oral mucositis in traditional Chinese medicinal material white flower and a preparation process of the effective part. The effective part is identified as a flavonoid component through standard substance spectrogram comparison. Tests prove that the production process of the effective part is practical and feasible, and the total flavonoids in the finally obtained extracting solution are greater than or equal to 50%. Besides, pharmacodynamic studies show that the effective part has a remarkable bacteriostasis effect on staphylococcus aureus, escherichia coli and candida albicans, the bacteriostasis rate is larger than or equal to 80%, the effective part has a remarkable treatment effect on rat oral mucosa acute inflammation caused by chemoradiotherapy, and the application prospect of the effective part in the adaptation disease is shown.

The invention provides a tool for intelligently evaluating the dystrophy risk of a patient with nasopharyngeal carcinoma, and the tool for evaluating the specific dystrophy of nasopharyngeal carcinoma is constructed by integrating indexes such as social demographic data, physique measurement, tumor staging, chemoradiotherapy conditions, recent adverse reactions and hematology indexes, so that high-precision risk evaluation is realized. Through single-factor and multi-factor analysis, the variable weight is optimized, and the discrimination capability and stability of the model are improved. An intelligent applet based on artificial intelligence is developed, patient data are extracted, nutrition risk calculation is completed within seconds, evaluation time is shortened, and clinical working efficiency is improved. The system also has the functions of dynamic monitoring and intelligent early warning, automatically updates the evaluation result along with the treatment progress of the patient, and provides individualized intervention suggestions. The defects that a traditional nutrition evaluation tool is high in subjectivity, low in efficiency, lack of tumor specificity and low in informatization degree are overcome, and an efficient, accurate and automatic intelligent evaluation solution is provided for clinic.

The invention discloses a nutrition intervention system and method for tumor chemoradiotherapy patients. The system comprises a molecular nutrition fingerprint acquisition module, a space-time prediction modeling module, a drug-nutrition collaborative optimization module, an intestinal flora-host metabolism modeling module and an active nutrition intervention execution module. By integrating gene polymorphism, intestinal flora and metabonomics data, an individualized molecular nutrition fingerprint is constructed, a deep learning algorithm is adopted to predict the change trend of a nutrition state, a molecular docking technology is adopted to optimize a drug-nutrition synergistic effect, a flora-host metabolism model is established to predict nutrient absorption efficiency, and the nutrient absorption efficiency is improved. And precise active nutrition intervention is realized. The technical problems that in the prior art, nutrition intervention is low in accuracy, preventive intervention cannot be achieved, and medicine-nutrition interaction is neglected are solved, and individualized nutrition management based on the molecular level is achieved.

The invention discloses a nano-vesicle composition for inhibiting tumor metastasis after radiotherapy, which is characterized in that the nano-vesicle is an engineered bacterial outer membrane vesicle (OS-D), and the composition also comprises a pH responsive phospholipid modification component and a small interfering RNA (siRNA) capable of silencing CCDC25 gene expression; the siRNA is used for inhibiting formation of neutrophil Extracellular Traps (NETs) induced by radiotherapy and tumor cell migration and metastasis mediated by the NETs by blocking the interaction between the NETs and tumor cells, so that the effect of inhibiting tumor metastasis after radiotherapy is realized. The nano-vesicle composition provided by the invention can specifically block tumor metastasis mediated by neutrophil extracellular traps in a tumor microenvironment so as to enhance the effect of tumor postoperative radiotherapy and chemotherapy and effectively inhibit tumor metastasis and relapse.

The present disclosure relates to novel radiation-triggered controlled release drug compositions, and methods to make and use the radiation-triggered controlled release drug compositions. The radiation-triggered controlled drug release nanoparticle formulations may be used to achieve maximum bioavailability and minimum adverse effects of the chemo drugs in chemo radio combination therapy treatment of locally advanced solid tumors.

The invention provides a hafnium oxide-based nano-drug as well as a preparation method and application thereof, and belongs to the technical field of nano-medicines. The preparation method comprises the following steps: mixing a hafnium chloride solution and an alkali solution, and carrying out hydrothermal reaction to obtain hafnium dioxide; mixing a bovine serum albumin solution and the hafnium oxide suspension, and performing centrifugal separation to obtain BSA modified hafnium oxide; adding a doxorubicin aqueous solution into the BSA modified hafnium oxide dispersion liquid for reaction to obtain doxorubicin-loaded hafnium oxide; and adding a potassium permanganate solution into the dispersion liquid of the doxorubicin-loaded hafnium oxide, and carrying out ultrasonic treatment to obtain the hafnium oxide-based nano-drug. The hafnium oxide-based nano-drug provided by the invention is a nano-drug capable of regulating and controlling the tumor microenvironment and combining the radiotherapy and chemotherapy functions, and can significantly improve the treatment response and benefit of patients.

This invention discloses a traditional Chinese medicine composition for treating tumors and its preparation method, belonging to the field of traditional Chinese medicine technology. The composition comprises *Uncaria rhynchophylla*, *Prunella vulgaris*, *Astragalus membranaceus*, *Adenophora stricta*, *Ophiopogon japonicus*, *Fritillaria thunbergii*, *Curcuma zedoaria*, *Panax notoginseng*, *Atractylodes macrocephala* (fried), *Ligustrum lucidum*, *Eclipta prostrata*, and *Glycyrrhiza uralensis* (processed). The formula focuses on clearing heat and detoxifying, resolving phlegm and dissipating nodules, strengthening the body's resistance, and promoting blood circulation and removing blood stasis. It combines tonification and purgation, addressing both the root cause and symptoms, precisely targeting the core pathogenesis of tumors: deficiency of vital energy, phlegm accumulation, blood stasis, and toxin accumulation. It can inhibit tumor cell proliferation, dissipate masses, enhance the body's immunity, reduce adverse reactions to radiotherapy and chemotherapy, improve clinical symptoms, stabilize tumors, and delay tumor progression and recurrence / metastasis, showing promising clinical application prospects.

This invention discloses the application of total paeoniflorin in the preparation of drugs for the treatment of head and neck squamous cell carcinoma, belonging to the field of biomedical technology. Addressing the bottlenecks in current treatments for head and neck squamous cell carcinoma, such as high toxicity of radiotherapy and chemotherapy, low response rates to immunotherapy, and easy resistance to targeted drugs, this invention provides a method for preparing total paeoniflorin and a drug-loaded preparation technology based on hydrogels obtained from modified chitosan. Total paeoniflorin can dose-dependently inhibit the proliferation rate, colony formation ability, and in vitro migration ability of SCC7, FADU, and CAL27 head and neck squamous cell carcinoma cell lines, and significantly induce apoptosis. This invention utilizes the multi-target effects of total paeoniflorin to exert anti-head and neck squamous cell carcinoma effects through modulation of the tumor microenvironment and enhancement of immune surveillance. Furthermore, the loaded drug exhibits good sustained-release properties and biosafety, providing a new, highly effective, and low-toxicity strategy for the treatment of head and neck squamous cell carcinoma, and has significant clinical application value.

The invention provides a method for enhancing the tumor homing ability of TIL cells, and belongs to the technical field of biological medicine. The invention provides a method for effectively enhancing the homing ability of TIL cells, so that the chemotactic and enrichment potential of engineered TIL cell products to tumor sites is remarkably improved. The TIL cell preparation prepared on the basis of the method has higher tumor targeting performance, and a new solution is provided for overcoming the bottleneck that effector cells'reach 'tumor parts in an existing cell therapy. The effectiveness of single cell therapy is expected to be directly improved, and better cell products can be provided for synergistic combination with other therapies such as radiotherapy and chemotherapy, so that wider and more effective treatment choices are brought to patients with solid tumors.

The invention discloses a molecular marker for evaluating prognosis of laryngeal squamous cell carcinoma and application of the molecular marker, and provides a molecular marker combination capable of accurately evaluating prognosis of laryngeal squamous cell carcinoma patients, and the prognosis of the laryngeal squamous cell carcinoma patients can be evaluated by detecting variation conditions of NOTCH1 genes, CCND1 genes and NFE2L2 genes. According to the detection result, the recurrence-free survival rate and recurrence risk of the laryngeal squamous cell carcinoma patient are rapidly and accurately evaluated at low cost, a new direction is provided for prognosis evaluation of the laryngeal squamous cell carcinoma patient, and a basis is provided for a subsequent treatment scheme of the patient. For example, a patient with high recurrence risk adopts an enhanced comprehensive treatment scheme (such as a radiotherapy and chemotherapy combined targeted treatment scheme), a patient with low recurrence risk avoids excessive treatment, and resource waste and side effects caused by invalid treatment are reduced.

The invention discloses an anti-cancer selenium-enriched soft-shelled turtle soup medicated diet and a making method thereof, and belongs to the technical field of traditional Chinese medicine medicated diets and functional foods. The medicated diet is prepared by taking selenium-rich soft-shelled turtle as a main material and combining traditional Chinese medicinal materials such as lucid ganoderma, astragalus membranaceus, medlar, Chinese yam and poria cocos through scientific proportioning and a staged low-temperature stewing process. The medicated diet disclosed by the invention is rich in selenium element and polysaccharide and triterpenoid active ingredients, and has remarkable effects of resisting oxidation, enhancing immunity and inhibiting tumor cell growth. According to the preparation method, the nutritional ingredients and pharmacodynamic substances are reserved to the maximum extent through the technologies of raw material pretreatment, step-by-step feeding, precise temperature control and the like. The medicine is suitable for adjuvant therapy of cancer patients, physique recovery after radiotherapy and chemotherapy and anti-cancer health care of high-risk groups.