Traditional Chinese medicine compound composition for adjuvant therapy of cancer and preparation method of traditional Chinese medicine compound composition

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine compound composition for adjuvant therapy of cancers and a preparation method thereof. Comprising the following traditional Chinese medicine components in parts by weight: 5-10 parts of scorpio, 10-20 parts of royal jelly freeze-dried powder, 5-15 parts of ginseng, 10-20 parts of rhizoma polygonati, 10-30 parts of astragalus membranaceus, 5-15 parts of dendrobium officinale, 10-20 parts of rehmannia, 5-15 parts of lucid ganoderma, 10-30 parts of oldenlandia diffusa, 10-20 parts of radix ophiopogonis, 5-15 parts of dogwood, 10-20 parts of codonopsis pilosula, 5-15 parts of liquorice, 0.1-0.5 part of selenium yeast, 5-15 parts of edible tulip, 10-20 parts of hawthorn, 5-15 parts of chrysanthemum and 10-30 parts of dandelion. And 3-10 parts of cinnamon. The scorpion, the pseudobulbus cremastrae seu pleiones and other components can directly inhibit tumor cell proliferation and induce apoptosis; the selenium yeast can scavenge free radicals and inhibit tumor angiogenesis. The royal jelly freeze-dried powder, the ginseng, the astragalus membranaceus, the lucid ganoderma and the like can activate immune cells, improve the immune monitoring ability of a body and relieve immunosuppression caused by radiotherapy and chemotherapy.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine compound composition for adjuvant therapy of cancer and a preparation method thereof. BACKGROUND

[0002] Cancer is a major disease that seriously threatens human health. At present, clinical treatment mainly adopts methods such as surgery, radiotherapy and chemotherapy. However, these methods are often accompanied by significant side effects, such as low immune function, bone marrow suppression, and digestive tract reactions. Traditional Chinese medicine has the advantages of multi-component, multi-target and overall regulation in adjuvant therapy of cancer, and can improve the quality of life of patients, reduce the toxic and side effects of radiotherapy and chemotherapy, and delay the progression of the disease. However, the existing traditional Chinese medicine compound still needs to be improved in terms of compatibility rationality, mechanism of drug efficacy and safety of clinical application. Therefore, it is urgent to develop a traditional Chinese medicine composition for adjuvant therapy of cancer with definite efficacy and high safety.

[0003] Therefore, the above technical problems need to be solved, and the present application provides a traditional Chinese medicine compound composition for adjuvant therapy of cancer and a preparation method thereof. SUMMARY

[0004] In order to overcome the shortcomings of the prior art, the present application provides.

[0005] In order to solve the above technical problems, the basic technical scheme provided by the present application is: A traditional Chinese medicine compound composition for adjuvant therapy of cancer, characterized in that it comprises the following traditional Chinese medicine ingredients in parts by weight: scorpion 5-10 parts, freeze-dried royal jelly 10-20 parts, ginseng 5-15 parts, yellow ginseng 10-20 parts, radix astragali 10-30 parts, dendrobium officinale 5-15 parts, radix rehmanniae 10-20 parts, ganoderma lucidum 5-15 parts, oldenlandia 10-30 parts, ophiopogon 10-20 parts, dogwood 5-15 parts, radix codonopsis 10-20 parts, licorice 5-15 parts, selenium yeast 0.1-0.5 parts, mountain yam 5-15 parts, hawthorn 10-20 parts, chrysanthemum 5-15 parts, dandelion 10-30 parts, cinnamon 3-10 parts.

[0006] Preferably, it further comprises 1-2 centipedes and 0.01-0.03 parts of toad venom.

[0007] Preferably, the weight parts of each traditional Chinese medicine ingredient are as follows: scorpion 6-8 parts, royal jelly freeze-dried powder 12-18 parts, ginseng 8-12 parts, rhizoma polygonati 12-18 parts, radix astragali 15-25 parts, dendrobium officinale 8-12 parts, radix rehmanniae 12-18 parts, ganoderma lucidum 8-12 parts, oldenlandia 15-25 parts, ophiopogon 12-18 parts, dogwood 8-12 parts, radix codonopsis 12-18 parts, licorice 6-12 parts, selenium yeast 0.2-0.4 parts, cordyceps 8-12 parts, hawthorn 12-18 parts, chrysanthemum 8-12 parts, dandelion 15-25 parts, cassia 5-8 parts, centipede 1-2, toad venom 0.01-0.02 parts.

[0008] A preparation method of a traditional Chinese medicine compound composition for adjuvant therapy of cancer, comprising the following steps: Scorpion, ginseng, rhizoma polygonati, radix astragali, dendrobium officinale, radix rehmanniae, ganoderma lucidum, oldenlandia, ophiopogon, dogwood, radix codonopsis, cordyceps, hawthorn, chrysanthemum, dandelion and cassia are taken by weight parts and crushed into coarse powder; 8-12 times of water is added and soaked for 30-60 minutes, and then boiled and simmered for 1-2 hours, filtered, and the filtrate is collected; The residue is added with 6-10 times of water and boiled for 0.5-1 hour, filtered, and the filtrates are combined; The filtrate is concentrated to a clear extract with a relative density of 1.10-1.20; Royal jelly freeze-dried powder, licorice and selenium yeast are added to the clear extract, mixed uniformly, dried, and granulated or tableted.

[0009] Preferably, the following steps are further included: The centipede is baked to yellow-brown and crushed into fine powder; Toad venom is dissolved in ethanol and added to the concentrated clear extract together with the centipede powder, and stirred uniformly.

[0010] The present application has the following advantages: Multi-path anti-tumor: ingredients such as scorpion and cordyceps can directly inhibit tumor cell proliferation and induce apoptosis; selenium yeast can scavenge free radicals and inhibit tumor angiogenesis.

[0011] Enhancing immune function: royal jelly freeze-dried powder, ginseng, radix astragali, ganoderma lucidum, etc. can activate immune cells, improve the immune surveillance ability of the body, and reduce the immunosuppression caused by radiotherapy and chemotherapy.

[0012] Regulating internal environment: Yin-nourishing herbs such as dendrobium officinale and radix rehmanniae can improve tumor microenvironment acidosis, and cassia and hawthorn can regulate metabolism and cut off the nutrient supply of tumors.

[0013] Reducing toxic and side effects: licorice can harmonize various drugs, reduce the toxicity of other drugs, and at the same time relieve symptoms such as gastrointestinal reactions and bone marrow suppression caused by radiotherapy and chemotherapy.

[0014] Synergism: the components produce synergistic effect through the compatibility principles of'strengthening healthy qi and eliminating pathogenic factors' and 'nourishing yin and clearing heat', improve the overall efficacy and prolong the survival period of patients. DETAILED DESCRIPTION

[0015] The technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the protection scope of the present application.

[0016] A traditional Chinese medicine compound composition for adjuvant therapy of cancer comprises the following traditional Chinese medicine ingredients in parts by weight: scorpion 5-10 parts, freeze-dried royal jelly 10-20 parts, ginseng 5-15 parts, rhizoma polygonati 10-20 parts, radix astragali 10-30 parts, dendrobium officinale 5-15 parts, radix rehmanniae 10-20 parts, ganoderma lucidum 5-15 parts, oldenlandia 10-30 parts, ophiopogon 10-20 parts, dogwood 5-15 parts, radix codonopsis 10-20 parts, licorice 5-15 parts, selenium yeast 0.1-0.5 parts, cordyceps 5-15 parts, hawthorn 10-20 parts, chrysanthemum 5-15 parts, dandelion 10-30 parts, and cassia 3-10 parts.

[0017] It also comprises 1-2 scorpions and 0.01-0.03 parts of toad venom.

[0018] A preparation method of a traditional Chinese medicine compound composition for adjuvant therapy of cancer comprises the following steps: Scorpion, ginseng, rhizoma polygonati, radix astragali, dendrobium officinale, radix rehmanniae, ganoderma lucidum, oldenlandia, ophiopogon, dogwood, radix codonopsis, cordyceps, hawthorn, chrysanthemum, dandelion, and cassia are weighed and crushed into coarse powder; 8-12 times the amount of water is added and soaked for 30-60 minutes, and then boiled and simmered for 1-2 hours, filtered, and the filtrate is collected; The residue is added with 6-10 times the amount of water and boiled for 0.5-1 hour, filtered, and the filtrates are combined; The filtrate is concentrated to a clear extract with a relative density of 1.10-1.20; Freeze-dried royal jelly, licorice, and selenium yeast are added to the clear extract, mixed uniformly, dried, and made into granules or tablets.

[0019] It also comprises the following steps: The scorpion is baked to yellow-brown and crushed into fine powder; Toad venom is dissolved in ethanol and added to the concentrated clear extract together with the scorpion powder, and stirred uniformly.

[0020] The specific embodiments are as follows: Embodiment 1 Raw material composition (parts by weight) Scorpion 6 parts, royal jelly freeze-dried powder 12 parts, ginseng 8 parts, yellow 12 parts, radix astragali 15 parts, dendrobium officinale 8 parts, rehmannia 12 parts, ganoderma 8 parts, oldenlandia 15 parts, ophiopogon 12 parts, dogwood 8 parts, radix codonopsis 12 parts, licorice 6 parts, yeast selenium 0.2 parts, mountain bitterling 8 parts, hawthorn 12 parts, chrysanthemum 8 parts, dandelion 15 parts, cassia 5 parts.

[0021] Preparation method Scorpion, ginseng, yellow, radix astragali, dendrobium officinale, rehmannia, ganoderma, oldenlandia, ophiopogon, dogwood, radix codonopsis, mountain bitterling, hawthorn, chrysanthemum, dandelion, cassia were crushed into coarse powder; Add 8 times the amount of water, soak for 30 minutes, boil and simmer for 1 hour, filter, collect the filtrate; Add 6 times the amount of water to the residue, decoct for 0.5 hours, filter, combine the filtrates; Concentrate the filtrate to a clear extract with a relative density of 1.10 (determined at 60°C); Add royal jelly freeze-dried powder, licorice, yeast selenium to the clear extract, mix evenly, dry, and make into tablets.

[0022] Example 2 Raw material composition (parts by weight) Scorpion 8 parts, royal jelly freeze-dried powder 18 parts, ginseng 12 parts, yellow 18 parts, radix astragali 25 parts, dendrobium officinale 12 parts, rehmannia 18 parts, ganoderma 12 parts, oldenlandia 25 parts, ophiopogon 18 parts, dogwood 12 parts, radix codonopsis 18 parts, licorice 12 parts, yeast selenium 0.4 parts, mountain bitterling 12 parts, hawthorn 18 parts, chrysanthemum 12 parts, dandelion 25 parts, cassia 8 parts.

[0023] Preparation method The same as example 1, only the weight parts of raw materials are different.

[0024] Example 3 Raw material composition (parts by weight) Scorpion 7 parts, royal jelly freeze-dried powder 15 parts, ginseng 10 parts, yellow 15 parts, radix astragali 20 parts, dendrobium officinale 10 parts, rehmannia 15 parts, ganoderma 10 parts, oldenlandia 20 parts, ophiopogon 15 parts, dogwood 10 parts, radix codonopsis 15 parts, licorice 9 parts, yeast selenium 0.3 parts, mountain bitterling 10 parts, hawthorn 15 parts, chrysanthemum 10 parts, dandelion 20 parts, cassia 6 parts, centipede 1, toad venom 0.015 parts.

[0025] Preparation method Prepare the clear extract according to steps 1-4 of example 1; Bake the centipede to yellow-brown, crush into fine powder; dissolve toad venom with ethanol; Centipede powder and toad venom ethanol solution are added to the clear extract, stirred evenly, dried, and made into tablets.

[0026] Comparative Example 1 Raw material composition (parts by weight) 12 parts of freeze-dried royal jelly powder, 8 parts of ginseng, 12 parts of polygonatum, 15 parts of astragalus, 8 parts of dendrobium officinale, 12 parts of rehmannia, 8 parts of ganoderma, 15 parts of oldenlandia diffusa, 12 parts of ophiopogon japonicus, 8 parts of cornus officinalis, 12 parts of codonopsis pilosula, 6 parts of licorice, 0.2 parts of yeast selenium, 12 parts of hawthorn, 8 parts of chrysanthemum, 15 parts of dandelion, and 5 parts of cinnamon.

[0027] Preparation method Same as Example 1.

[0028] Experimental Example: Comparison of Anti-tumor and Immunomodulatory Effects Experimental subjects Forty tumor-bearing mice (H22 liver cancer model) were selected and randomly divided into four groups: Example 1, Example 2, Example 3, and Comparative Example 1, with 10 mice in each group.

[0029] Administration method Administer the drug by gavage at a dose of 0.2 mL / 10 g body weight, once daily for 14 consecutive days.

[0030] detection indicators Tumor inhibition rate: Mice were sacrificed after the last administration, tumors were removed, weighed, and the tumor inhibition rate was calculated.

[0031] Tumor inhibition rate (%) = (Tumor weight in control group - Tumor weight in treatment group) / Tumor weight in control group × 100% Immune markers: Blood samples were taken to detect CD4+ T cell levels.

[0032] Experimental results

[0033] The data in the table show that all three groups of Examples 1-3 exhibited significant antitumor and immunomodulatory effects. Specifically, Example 3 (containing centipede and toad venom) showed significantly higher tumor inhibition rates and CD4+ T cell levels than Examples 1 and 2 (without centipede and toad venom) and Comparative Example 1 (without key antitumor components), indicating that the addition of centipede and toad venom significantly enhances the antitumor activity and immunomodulatory capacity of the composition. Comparative Example 1, lacking direct antitumor components such as scorpion and *Cremastra appendiculata*, showed a significantly reduced effect, verifying the scientific validity and necessity of the compositional formulation of this invention.

[0034] Those skilled in the art can make various modifications and changes to the above embodiments according to the disclosure and teachings herein. Therefore, the application is not limited to the specific embodiments disclosed and described above, and some modifications and changes to the application shall fall within the protection scope of the claims of the application. In addition, although some specific terms are used in the specification, these terms are only for convenience of description and do not constitute any limitation on the application.

Claims

1. A traditional Chinese medicine compound composition for adjuvant therapy of cancer, characterized in that, The traditional Chinese medicine ingredients include the following components in parts by weight: scorpion 5-10 parts, royal jelly freeze-dried powder 10-20 parts, ginseng 5-15 parts, yellow ginseng 10-20 parts, milk vetch 10-30 parts, iron Dendrobium 5-15 parts, Rehmannia 10-20 parts, Ganoderma 5-15 parts, oldenlandia 10-30 parts, ophiopogon 10-20 parts, dogwood 5-15 parts, codonopsis 10-20 parts, licorice 5-15 parts, selenium yeast 0.1-0.5 parts, mountain yam 5-15 parts, hawthorn 10-20 parts, chrysanthemum 5-15 parts, dandelion 10-30 parts, and cinnamon 3-10 parts.

2. The traditional Chinese medicine compound composition for adjuvant therapy of cancer according to claim 1, characterized in that, It also includes 1-2 centipedes and 0.01-0.03 parts of toad venom. 3.The traditional Chinese medicine compound composition for adjuvant therapy of cancer according to claim 1 or 2, characterized in that, The parts by weight of each traditional Chinese medicine ingredient are as follows: scorpion 6-8 parts, royal jelly freeze-dried powder 12-18 parts, ginseng 8-12 parts, yellow ginseng 12-18 parts, milk vetch 15-25 parts, iron Dendrobium 8-12 parts, Rehmannia 12-18 parts, Ganoderma 8-12 parts, oldenlandia 15-25 parts, ophiopogon 12-18 parts, dogwood 8-12 parts, codonopsis 12-18 parts, licorice 6-12 parts, selenium yeast 0.2-0.4 parts, mountain yam 8-12 parts, hawthorn 12-18 parts, chrysanthemum 8-12 parts, dandelion 15-25 parts, cinnamon 5-8 parts, 1-2 centipedes, and 0.01-0.02 parts of toad venom.

4. A preparation method of the traditional Chinese medicine compound composition for adjuvant therapy of cancer, applied to the traditional Chinese medicine compound composition for adjuvant therapy of cancer according to any one of claims 1-2, characterized in that, The method comprises the following steps: Scorpion, ginseng, yellow ginseng, milk vetch, iron Dendrobium, Rehmannia, Ganoderma, oldenlandia, ophiopogon, dogwood, codonopsis, mountain yam, hawthorn, chrysanthemum, dandelion, and cinnamon are weighed and crushed into coarse powder; 8-12 times the amount of water is added and soaked for 30-60 minutes, and then boiled and simmered for 1-2 hours, filtered, and the filtrate is collected; The residue is added with 6-10 times the amount of water and boiled for 0.5-1 hour, filtered, and the filtrates are combined; The filtrate is concentrated to a clear extract with a relative density of 1.10-1.20; Royal jelly freeze-dried powder, licorice, and selenium yeast are added to the clear extract, mixed uniformly, dried, and granulated or tableted.

5. The traditional Chinese medicine compound composition for adjuvant therapy of cancer according to claim 4, characterized in that, The method further comprises the following steps: The centipedes are baked to yellow-brown and crushed into fine powder; Toad venom is dissolved in ethanol and added to the concentrated clear extract together with the centipede powder, and stirred uniformly.

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