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Gargle for preventing and treating mouth mucositis caused by chemoradiotherapy

A technology for oral mucositis and gargle, which is applied in the direction of anti-inflammatory agents, digestive system, drug delivery, etc., can solve the problems of oral mucositis pain, lack of effective treatment drugs, and inability to eat normally, so as to promote penetration and absorption, The preparation process is simple, and the effect of inhibiting oral mucosal reaction

Inactive Publication Date: 2016-09-28
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The object of the present invention is: aim at above-mentioned deficiencies in the prior art, provide a kind of oral mucositis gargle that prevents and treats the oral mucositis that radiochemotherapy causes, to solve the symptom that oral mucositis shows pain and cannot eat normally because of radiochemotherapy at present. The problem of lack of effective treatment drugs

Method used

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  • Gargle for preventing and treating mouth mucositis caused by chemoradiotherapy

Examples

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Effect test

Embodiment 1

[0023] 1000ml gargle: 1g doxepin hydrochloride, 20g dimethyl sulfoxide, 50g glycerin, and purified water to 1000ml.

[0024] Preparation method: first weigh doxepin hydrochloride, add 50ml of purified water and stir to dissolve doxepin hydrochloride, then add dimethyl sulfoxide and glycerin in sequence, and finally add purified water to 1000ml, and stir evenly.

Embodiment 2

[0026] 1000ml gargle: 20g doxepin hydrochloride, 50g dimethyl sulfoxide, 100g glycerin, and add purified water to 1000ml.

[0027] Preparation method: first weigh doxepin hydrochloride, add 80ml of purified water and stir to dissolve doxepin hydrochloride, then add dimethyl sulfoxide and glycerin in sequence, and finally add purified water to 1000ml, and stir evenly.

Embodiment 3

[0029] 1000ml gargle: Doxepin hydrochloride 30g, dimethyl sulfoxide 80g, glycerin 120g, purified water to 1000ml.

[0030] Preparation method: first weigh doxepin hydrochloride, add 50ml of purified water, stir to dissolve doxepin hydrochloride, then add dimethyl sulfoxide and glycerin in sequence, and finally add purified water to 1000ml, and stir evenly.

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Abstract

The invention provides gargle for preventing and treating mouth mucositis caused by chemoradiotherapy. The gargle is prepared from hydrochloric acid doxepin, glycerol, dimethyl sulfoxide and purified water. Every 100 ml of the gargle is prepared from 0.1-10 g of hydrochloric acid doxepin, 5-20 g of glycerol, 2-20 g of dimethyl sulfoxide and the balance water. Hydrochloric acid doxepin serves as a main active ingredient, and glycerol and dimethyl sulfoxide serve as auxiliary materials. Hydrochloric acid doxepin has the effects of restraining nerve functional pain and mouth mucosa reactions, so that euphagiaof a patient is promoted, and normal treatment on the patient is guaranteed. The prepared gargle can effectively treat pain and abnormal food uptake symptoms shown due to mouth mucositis caused by chemoradiotherapy, and the gargle is different from medicine which is used for treating mouth mucositis caused by chemoradiotherapy and has definite clinical effects on the existing market. The gargle is simple in preparation process, controllable in quality and suitable for industrial production.

Description

technical field [0001] The invention relates to a gargle for preventing and treating oral mucositis caused by radiotherapy and chemotherapy, in particular to a gargle for treating oral mucositis caused by radiotherapy and chemotherapy, which uses doxepin hydrochloride as the main active ingredient. Background technique [0002] In recent years, the incidence of nasopharyngeal carcinoma and other head and neck tumors has been on the rise. Radiotherapy and chemotherapy are currently one of the important means of treating the aforementioned swelling and pain diseases. However, radiotherapy and chemotherapy can easily cause damage to the normal tissues around the lesion damage. Oral mucosa is one of the tissues that are most likely to be affected by radiation in the course of radiotherapy and chemotherapy for patients with head and neck cancer. Once it is involved, it will show acute oral mucosal reaction. Oral mucositis is one of the most common and most influential acute reac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/10A61K47/20A61K31/335A61P29/00A61P1/02
CPCA61K9/08A61K9/006A61K31/335A61K47/10A61K47/20
Inventor 唐芳马进安丁登峰向大雄
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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