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Supramolecular nucleoside hydrogel and preparation method and application thereof

A molecular nucleoside water and hydrogel technology, applied in the field of biomedical materials, can solve the problems of unsatisfactory application, poor stability of D-type guanosine hydrogel, and stability of D-type guanosine hydrogel Improve problems such as difficult problems to achieve the effect of excellent stability and good injectability

Active Publication Date: 2021-07-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is still a difficult problem to improve the stability of D-guanosine hydrogel
[0007] Due to poor stability, D-type guanosine hydrogel cannot be used as drug sustained-release preparations and tissue engineering soft materials

Method used

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  • Supramolecular nucleoside hydrogel and preparation method and application thereof
  • Supramolecular nucleoside hydrogel and preparation method and application thereof
  • Supramolecular nucleoside hydrogel and preparation method and application thereof

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Experimental program
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Embodiment 1

[0040] Embodiment 1, the preparation of supramolecular nucleoside hydrogel of the present invention

[0041] Dissolve α-deoxyguanosine (α-dG) in KCl aqueous solution with a concentration of 0.2mol / L, heat the solution (80-100°C) until α-dG is fully dissolved, and the concentration of α-dG in the obtained solution is It is 1.4% w / v (ie 1.4 mg / 100 μl). After cooling the solution at room temperature (25°C) for 5-10 minutes, a translucent α-dG hydrogel (supramolecular nucleoside hydrogel of the present invention) was obtained.

[0042] Use the vial inversion test at room temperature to confirm the formation of the gel. Invert the vial containing the hydrogel. If no sample flow is observed, the formation of the hydrogel can be confirmed, and then the stability of the hydrogel is observed and recorded. The stability of the hydrogel prepared in embodiment 1 is as follows: figure 1 shown. Depend on figure 1 It can be seen that the α-dG hydrogel exhibited good stability, and the ...

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Abstract

The invention provides supramolecular nucleoside hydrogel and a preparation method and application thereof, and belongs to the field of biomedical materials. In a powder X-ray diffraction pattern of the hydrogel, diffraction peaks exist at 2theta diffraction angles of 26.7 degrees, 28.4 degrees and 40.5 degrees. The supramolecular hydrogel based on D-configuration alpha-deoxyguanosine is successfully constructed, the alpha-dG hydrogel has excellent stability and cannot be disintegrated and damaged after being placed for 18 months, and the problem that in the prior art, supramolecular hydrogel formed by D-type guanosine is poor in stability is solved. Besides, the alpha-dG hydrogel has good injectability, biocompatibility and drug delivery capacity, can be used as a drug carrier, and is expected to be further applied in the field of biomedicine, such as local treatment of oral mucosa diseases.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a supramolecular nucleoside hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a high molecular polymer material with a cross-linked structure that is hydrophilic but insoluble in water and can absorb a large amount of water with water as the dispersion medium. It has good biocompatibility and can reduce adverse reactions as a human implant, so it is widely used as an excellent biomedical material. [0003] There are two types of hydrogels, chemical gels and physical gels. The gel molecules of chemical gels are connected by covalent bonds without thermal reversibility; the gel molecules of physical gels are connected by intermolecular forces, hydrogen bonds, electrostatic interactions, π-π bonds, hydrophobic interactions, coordination bonds, etc. Connected and thermally reversible. [0004] Supramolecular hydrogel is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/00A61L27/28A61K47/26
CPCA61L27/52A61L27/00A61L27/28A61K47/26
Inventor 刘江赵行倪广成但红霞陈谦明
Owner SICHUAN UNIV
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